BRAIN GLUCOSE TRANSPORT IN SUBJECTS & PATIENTS WITH DIABETES FOLLOWING HYPOGLYC

受试者中的脑葡萄糖转运

• 批准号: 7601633
• 负责人: ELIZABETH R. SEAQUIST
• 金额: $ 8.26万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601633
• 关键词: Brain; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Diabetes Mellitus; Exposure to; Funding; Glucose; Glucose Clamp; Grant; Hyperglycemia; Hypoglycemia; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Measures; Metabolic; Metabolism; NMR Spectroscopy; Patients; Personal Satisfaction; Plasma; Recurrence; Research; Research Personnel; Resources; Somatostatin; Source; United States National Institutes of Health; Weight; glucose transport; hypoglycemia unawareness; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although it is well established that recurrent hypoglycemia leads to hypoglycemia unawareness, the mechanisms responsible for this are unknown. One hypothesis is that recurrent hypoglycemia alters brain glucose transport or metabolism. We measured steady-state brain glucose concentrations during a glucose clamp to determine whether subjects with type 1 diabetes and hypoglycemia unawareness may have altered cerebral glucose transport or metabolism after exposure to recurrent hypoglycemia. We compared 14 subjects with diabetes and hypoglycemia unawareness to 27 healthy control subjects. Brain glucose concentrations were measured under similar metabolic conditions using in vivo 1H nuclear magnetic resonance (NMR) spectroscopy at 4 Tesla during a hyperglycemic clamp (plasma glucose = 16.7 mmol/l) with somatostatin and insulin. Subjects with type 1 diabetes and hypoglycemia unawareness had significantly higher brain glucose concentrations compared to that in controls under the same conditions (5.5 ¿ 0.3 vs. 4.7 ¿ 0.1 mol/g wet weight, P = 0.016). These data suggest that changes in brain glucose transport or metabolism may occur as a result of recurrent hypoglycemia

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 尽管众所周知，反复发生低血糖会导致低血糖无意识，但其机制尚不清楚。一种假设是，反复发生的低血糖会改变大脑葡萄糖转运或代谢。我们在葡萄糖钳夹过程中测量了稳态脑葡萄糖浓度，以确定患有 1 型糖尿病且无意识低血糖的受试者在经历反复低血糖后是否可能改变了脑葡萄糖转运或代谢。我们将 14 名患有糖尿病和低血糖的受试者与 27 名健康对照受试者进行了比较。在使用生长抑素和胰岛素的高血糖钳夹（血浆葡萄糖 = 16.7 mmol/l）期间，使用 4 特斯拉体内 1H 核磁共振 (NMR) 光谱在类似的代谢条件下测量脑葡萄糖浓度。在相同条件下，患有 1 型糖尿病且无意识发生低血糖的受试者的脑葡萄糖浓度显着高于对照组（5.5±0.3 vs. 4.7±0.1 mol/g 湿重，P = 0.016）。这些数据表明，反复发生低血糖可能会导致大脑葡萄糖转运或代谢发生变化