IN VIVO MAGNETIC RESONANCE STUDIES OF GLUCOSE METABOLISM IN HUMANS AT 4 TESLA US

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 在这个项目中，我们打算开发非侵入性的方法来定量评估功能激活过程中的脑代谢。 本项目的假设是脑功能激活改变脑谷氨酸周转。 这一假设的基础是谷氨酸转换的测量反映了三羧酸（TCA）循环的速率，从而反映了氧的脑代谢速率（CMR 02）。 进行这些研究的关键是使用葡萄糖钳夹技术对血清葡萄糖和胰岛素浓度进行实验控制和测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project we intend to develop non-invasive methods to quantitatively assess cerebral metabolism during functional activation. The hypothesis of this project is that brain functional activation alters cerebral gluramate turnover. The basis for this assumption is that the measurement of glutamate turnover reflects the rate of the tricarboxylic acid (TCA) cycle and thus the cerebral metabolic rate of oxygen (CMR02). Essential to their performance of these studies will be experimental control and measurement of serum glucose, and insulin concentrations using the techniques employed for glucose clamps.