Lab-on-a-Pill: wireless microfluidics for in vivo immunodiagnostics

Lab-on-a-Pill：用于体内免疫诊断的无线微流体

• 批准号: BB/E015212/1
• 负责人: Jonathan Cooper
• 金额: $ 90.32万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE015212%2F1
• 关键词: Lab; Pill; wireless; microfluidics; vivo

Previously, Lab-on-a-Chip technologies have exploited many aspects of microsystems technology, including both sensor miniaturisation and microfluidics, to produce technologies associated with DNA analysis, proteomics and diagnostics. Despite the numerous analytical advantages that are delivered as a consequence of miniaturisation into Lab-on-a-Chip, the vast majority of all devices that have been proposed (with the exception of handheld biosensors, first developed 20 years ago), most often require to be based on a laboratory bench. In contrast, wireless 'Lab-on-a-Pill' technology now has the proven ability to deliver both remote and-or distributed analysis, resulting in a wide range of potential applications, including those associated with biomedical analysis in the gastro-intestinal (GI) tract, process control in industry, environmental analysis and the functional foods industry. The concept is one of a battery-powered technology platform, which combines miniaturised sensors, a low power radio transmitter and receiver and power management modules, and an array of microsensors. Our current prototype can measure pH, disolved oxygen (pO2), temperature and conductivity, and has been proven with wireless measurements in a pig, using radiotelemtry to track its position. The device is controlled by an ASIC. This application now seeks to implement important technological challenges associated with implementing microfluidics on the Pill in order to enable advanced diagnostic tests. In this project we will illustrate this by performing remote immunodiagnostics. As an example, we will try to perform a remote biochemical assay for a marker for colon cancer in the lower GI tract.

此前，芯片实验室技术已经利用了微系统技术的许多方面，包括传感器小型化和微流体技术，以生产与DNA分析、蛋白质组学和诊断相关的技术。尽管芯片实验室小型化带来了许多分析优势，但绝大多数已提出的设备（20年前首次开发的手持生物传感器除外）通常需要基于实验室工作台。相比之下，无线“药丸实验室”技术现在已经被证明能够提供远程和或分布式分析，从而产生广泛的潜在应用，包括与胃肠道（GI）的生物医学分析、工业过程控制、环境分析和功能食品工业相关的应用。这个概念是一个电池供电的技术平台，它结合了微型传感器、低功率无线电发射器和接收器、电源管理模块以及微传感器阵列。我们目前的原型可以测量pH值、溶解氧（pO2）、温度和电导率，并且已经在猪身上进行了无线测量，使用无线电遥测技术来跟踪其位置。该设备由ASIC控制。该应用程序现在寻求实现与在药丸上实施微流体相关的重要技术挑战，以便实现先进的诊断测试。在这个项目中，我们将通过执行远程免疫诊断来说明这一点。作为一个例子，我们将尝试执行远程生化分析标记结肠癌在下消化道。