EFFECTS OF HIV ON BONE MASS IN THE ELDERLY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的具体目的将是比较一组HIV阳性的老年女性和男性与匹配的HIV阴性对照组，以确定骨密度和骨转换的生化标记物的差异。艾滋病毒感染是一个重大的世界性公共卫生问题。美国的患者可以获得高效抗逆转录病毒疗法(HAART)，近年来，这种疗法降低了发病率，延长了生命。然而，这些药物与显著的代谢紊乱有关，如葡萄糖耐量异常、高脂血症和脂肪营养不良。初步的临床和实验室数据表明，接受或不接受HAART治疗的艾滋病毒患者患骨质疏松症的风险增加。同时，最近HIV患者的平均年龄有了显著的增加，这些患者的代谢障碍，包括对骨骼的可能影响，仍然没有特征性。因此，这项研究的长期目标将是检查艾滋病毒对老年人群骨量的影响。中心假设是HIV阳性的老年女性和男性的骨量低于匹配的HIV阴性对照组。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim of the study will be to compare a cohort of elderly HIV positive females and males with matched HIV-negative controls to determine differences in bone mineral density and biochemical markers of bone turnover. HIV infection is a major worldwide public health problem. Patients in the United States have access to highly active antiretroviral therapy (HAART) that has, in recent years, decreased morbidity and prolonged life. However, these agents are associated with significant metabolic disturbances such as glucose intolerance, hyperlipidemia and lipodystrophy. Initial clinical and laboratory data suggest that patients with HIV with or without HAART therapy are at increased risk of osteoporosis. In parallel, there has been a notable recent increase in the mean age of HIV pateints in whom metabolic disturbances, including possible effects on bone, remain uncharacterized. Therefore, the long-term goal of this study will be to examine the effects of HIV on bone mass in the elderly population. The central hypothesis is that HIV positive elderly women and men have lower bone mass than matched HIV negative controls.