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Clinical and Translational Science Award

临床和转化科学奖

基本信息

批准号：
10357784
负责人：
MARLA J KELLER
金额：
$ 427.42万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-22 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10357784
关键词：
Advisory Committees Aging Appointment Biological Assay Biological Markers Biomedical Research Caring Child Health Clinical Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Collaborations Communities Community Healthcare Competence Drug Design Ecosystem Evaluation Faculty Fostering Funding Gender Generations Goals Health Care Research Healthcare Informatics Infrastructure Institutes Integrated Health Care Systems Investments Knowledge Laboratory Research Leadership Longevity Mentors Methods Mission Multi-Institutional Clinical Trial National Center for Advancing Translational Sciences New York City Pathway interactions Phase Pilot Projects Play Positioning Attribute Process Research Research Personnel Research Support Resource Development Resources Role Safety Scientist Services Special Population Structure Training Training and Education Translational Research Work Workforce Development authority biobank biomedical informatics career development clinical practice community engaged research community engagement implementation science improved innovation next generation novel novel diagnostics novel therapeutics patient safety population health practice-based research network precision medicine programs translational pipeline

项目摘要

The Einstein-Montefiore Institute for Clinical and Translational Research (ICTR) has evolved over the past two CTSA funding periods, embracing the broad spectrum of clinical and translational (C/T) biomedical research from T1 through T4. We have provided pathways for our clinicians and our integrated healthcare system to expand implementation science, population health, community-engaged research, and clinical trials while also encouraging basic scientists to innovate new therapeutics and diagnostics. This broad involvement with our community and investigators has allowed the CTSA to impact a wide range of research extending from drug design and improving clinical trials management, to training a new research workforce, and to using implementation science for community-engaged and healthcare research. Indeed, the ICTR’s mission—to advance research across the translational spectrum into clinical practice through its integrated infrastructure, innovative training, and institutional co-investment—has evolved in step with that of the National Center for Advancing Translational Sciences. In this application, we will 1) leverage CTSA resources with institutional assets that support state-of-the-art informatics to accelerate the transfer of discoveries to healthcare via an Evidence Generation Framework, and support regulatory streamlining, innovative analytics, and assist with all phases of C/T research; 2) develop the next generation of research workforce and teams, using novel education, training, mentoring, pilot study support, and career development resources that span translational domains; 3) expand collaborations and engagement, both with the CTSA network and other hubs, and the Bronx community and healthcare partners in an integrative paradigm with strategies developed in collaboration with community partners, investigators, and institutional leadership to improve population health; 4) advance life span, child health, and aging research across genders and special populations, by working with unique platforms for stakeholder-engaged research, patient safety and implementation science, the Montefiore Accountable Care Organization, and the New York City Practice-Based Research Network; and 5) innovate methods and processes that advance C/T sciences, and enhance quality, safety, and efficiency of C/T research. We will integrate the CTSA Trial Innovation Network into our ecosystem of multisite clinical trials, foster innovative methods for biomarker assays and biobanking for precision medicine, and leverage the CTSA Common Metrics Initiative to support our hub’s Evaluation and strategic management. Overall, the Einstein- Montefiore ICTR will fulfill NCATS’s tripartite mission to innovate, educate, and implement.

爱因斯坦-蒙蒂菲奥里临床和转化研究所（ICTR）在过去两年中不断发展。 CTSA资助期，涵盖广泛的临床和转化（C/T）生物医学研究从T1到T4我们为临床医生和综合医疗保健系统提供了途径，扩大实施科学，人口健康，社区参与的研究和临床试验，同时也鼓励基础科学家创新新的治疗和诊断方法。这种广泛的参与，社区和研究人员允许CTSA影响从药物到广泛的研究设计和改进临床试验管理，培训新的研究人员，并使用社区参与和医疗保健研究的实施科学。事实上，卢旺达问题国际法庭的任务是通过其综合基础设施，将跨转化谱的研究推进到临床实践中，创新培训和机构共同投资-已经与国家中心同步发展，推进转化科学。在此应用程序中，我们将1）利用CTSA资源与机构支持最先进的信息学的资产，以通过证据生成框架，并支持监管简化、创新分析，并协助所有 C/T研究的阶段; 2）开发下一代的研究队伍和团队，使用新的教育、培训、指导、试点研究支持和职业发展资源， 3）扩大与CTSA网络和其他中心的合作和参与，布朗克斯社区和医疗保健合作伙伴在一个综合的范例与合作开发的战略与社区合作伙伴、调查人员和机构领导合作，改善人口健康; 4）推进寿命，儿童健康，以及跨性别和特殊人群的老龄化研究，通过与独特的 Montefiore是利益相关者参与研究、患者安全和实施科学的平台责任关怀组织和纽约市基于实践的研究网络; 5）创新推进C/T科学，提高C/T质量、安全和效率的方法和流程 research.我们将把CTSA试验创新网络整合到我们的多中心临床试验生态系统中，为精准医学培养生物标志物测定和生物库的创新方法，并利用CTSA 支持我们中心的评价和战略管理的共同倡议。总的来说，爱因斯坦- Montefiore ICTR将履行NCATS的三重使命，即创新、教育和实施。