ACTG 219: PEDIATRIC LATE OUTCOMES (AIDS)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。有必要更好地评估对儿童进行的各种抗艾滋病毒治疗的积极和消极的后期后果。本研究旨在收集前瞻性、纵向数据，以确定1)与艾滋病毒疾病进展、治疗或预防性干预和/或艾滋病毒疾病与治疗的相互作用相关的晚期结局和后果；2)围产期治疗的未感染婴儿的晚期治疗效果。数据将包括病史、生活质量评估、体格检查、神经认知测试、临床和实验室评估、发病率和死亡率。该研究将持续到孩子年满21岁或无法随访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a need to better assess both positive and negative late consequences of the various anti-HIV therapies administered to children. This study is designed to collect prospective, longitudinal data to identify 1)late outcomes and consequences related to HIV disease progression, treatment or prophylactic intervention, and/or interaction of HIV disease and therapy and 2) late treatment effects among perinatally treated infants proven to be uninfected. Data will include history, quality of life assessment, physical exam, neurocognitive testing, clinical and laboratory evaluations, morbidity, and mortality. The study will last until the child reaches his/her 21st birthday or is lost to follow-up.