BIOMARKERS OF BRAIN PATHOLOGY IN CHILDREN WITH TRAUMATIC BRAIN INJURY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。创伤性脑损伤（TBI）每年造成的儿童死亡和残疾人数超过任何其他原因（Duhaime和Raghupathi 1999），是儿童和年轻人长期残疾的主要原因（美国国立卫生研究院，1999）。尽管这是一个紧迫的健康问题，但我们对人类急性脑损伤相关的病理机制事件的理解仍然非常有限，并且在这种临床环境中没有经过验证的儿童或成人治疗方法。这项针对TBI儿童的研究旨在描述选定血液和脊髓液生物标志物浓度与高级神经监测参数与患者结局之间的相关性。基于该分析，可以鉴定潜在有用的生物标志物和神经监测参数。后者将有几个重要的临床应用：它可以让我们1）根据TBI的严重程度对患者进行分层; 2）更好地监测脑损伤引起的病理和恢复的进展; 3）指导治疗; 4）监测治疗/干预的效果; 5）更准确地预测儿童创伤性脑损伤后的结果。准确的患者分层和有效的预测结果的方法是至关重要的，随后进行的临床试验，在这一患者群体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury (TBI) kills and disables more children each year than any other cause (Duhaime and Raghupathi 1999) and is the leading cause of long-term disability in children and young adults (National Institutes of Health, 1999). Despite the fact that it is a pressing health issue, our understanding of the pathomechanistic events associated with acute brain injury in humans remains quite limited, and there are no proven therapies for children or adults in this clinical setting. This study in children suffering TBI is designed to characterize the association between the concentrations of selected blood and spinal fluid biomarkers and advanced neuro-monitoring parameters with patient outcome. Based on that analysis, potentially useful biomarkers and neuro-monitoring parameters may be identified. The latter will have several important clinical applications: it may allow us 1) to stratify patients by the severity of their TBI; 2) to better monitor the progression of brain injury-induced pathology and recovery; 3) to guide therapy; 4) to monitor the effects of therapy/intervention; and 5) to predict outcome more accurately after traumatic brain injury in children. Accurate patient stratification and valid methods of predicting outcome are vital to the subsequent conduct of clinical trials in this patient population.