DISTRIBUTION OF TOTAL BODY WATER AND FLUID DISTRIBUTION IN CRITICALLY ILL ELD

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是设计一种基于多频生物电阻抗分析（MBIA）的基于全身水分（TBW）的危重病人药物剂量计算方法。这种相对较新的方法是一种无创且简单的床边技术，可用于预测TBW、细胞外水（ECW），并识别危重疾病后液体分布的变化。此外，我们还希望进行“金标准”示踪剂研究（氧化氘和溴化钠），以验证MBIA测量身体成分的方法。MBIA测量的TBW和ECW与使用氘稀释和溴化钠测量的结果在统计学上没有差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to design a simple method of calculating drug dosage in a critically ill patient based on total body water (TBW) using multifrequency bioelectrical impedance analysis (MBIA). This relatively new method is a noninvasive and simple bedside technique that can be used to predict TBW, extracellular water (ECW), and identify altered fluid distribution following critical illness. In addition, we would also like to perfrom "gold standard" tracer studies (deuterium oxide, and sodium bromide) to validate MBIA method of measuring body composition. TBW and ECW measured by MBIA will not be statistically different from measurements obtained using deuterium dilution and sodium bromide.