DISTRIBUTION OF TOTAL BODY WATER AND FLUID DISTRIBUTION IN CRITICALLY ILL ELD

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是设计一个简单的方法来计算药物剂量在危重病人的基础上，总的身体水分（TBW），使用多频生物电阻抗分析（MBIA）。这种相对较新的方法是一种无创和简单的床边技术，可用于预测TBW，细胞外水（ECW），并确定危重病后改变的液体分布。此外，我们还想进行“金标准”示踪剂研究（氧化氘和溴化钠），以验证MBIA测量身体成分的方法。通过MBIA测量的TBW和ECW与使用氘稀释和溴化钠获得的测量值没有统计学差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to design a simple method of calculating drug dosage in a critically ill patient based on total body water (TBW) using multifrequency bioelectrical impedance analysis (MBIA). This relatively new method is a noninvasive and simple bedside technique that can be used to predict TBW, extracellular water (ECW), and identify altered fluid distribution following critical illness. In addition, we would also like to perfrom "gold standard" tracer studies (deuterium oxide, and sodium bromide) to validate MBIA method of measuring body composition. TBW and ECW measured by MBIA will not be statistically different from measurements obtained using deuterium dilution and sodium bromide.