INBRE UNDERGRADUATE RESEARCH EXPERIENCE CORE

INBRE 本科研究经验核心

• 批准号: 7381587
• 负责人: LISA ANN PLOWFIELD
• 金额: $ 30.6万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381587
• 关键词: INBRE; UNDERGRADUATE; RESEARCH; EXPERIENCE; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Undergraduate Research Experience Core Core Directors: Dr. Lisa Plowfield, UD School of Nursing Ms. Jeanette Miller, DBI Research Administrator Dr. Cliff Robinson, UD Dept. of Chemistry and Biochemistry Core Objective: To strengthen the biomedical research skills of undergraduates by involving them in faculty research. School of Nursing Undergraduate Research The School of Nursing offered NURS362: Research Concepts in Healthcare both during Fall 2005 and Spring 2006 semesters. During the Fall, 76 undergraduate nursing students were enrolled; 25 are enrolled for the Spring 2006 semester. All students participated in nursing faculty research activities. A total of 7 faculty researchers led small group research initiatives. As a result of this type of activity, nine posters have been accepted at an annual regional nursing research conference sponsored by the Delaware Nurses Association and Schools of Nursing honor societies. The following list identifies the projects on which students served as research assistants: ¿ A woman¿s sexual orientation: A determinant of gynecological practices. (Faculty sponsor: Dr. Carolee Polek) ¿ Role of sexual orientation in seeking healthcare. (Faculty sponsor: Dr. Carolee Polek) ¿ Comparison of upper arm and forearm automatic, noninvasive blood pressures in college students. (Faculty sponsor: Kathy Schell) ¿ A survey of job enjoyment in direct-care registered nurses with baccalaureate degrees and non baccalaureate degrees. (Faculty sponsor: Linda Bucher) ¿ Perceptions of instructor caring: Qualitative analysis of caring and non-caring vignettes. (Faculty sponsor: Gail Wade) ¿ A pilot study of predictors of intensive exercise among college students. (Faculty sponsors: Erlinda Wheeler & Paula Klemm) ¿ The link between risk taking and drug use at college. (Faculty sponsor: Tom Hardie) ¿ Siblings¿ perceptions of diabetes and its treatment. (Faculty sponsor: Judy Herrman) ¿ The effect of average hours worked on nurse job enjoyment. (Faculty sponsor: Karen Avino) ¿ A literature review of unmet needs of older hospitalized patients. (Faculty sponsor: Diane Mick) Student evaluation responses were a mix of positive and negative. Those students who reported a negative experience noted difficulty understanding how a nursing research course would be beneficial to them in a nursing practice career and that the time-intensive nature of research process was not satisfactory to them. Student responses who noted a positive experience reported working with faculty on actual research projects was beneficial, group process was important, and a benefit of participating in research outcomes of poster presentations and publications. Faculty were asked to respond to a survey about these undergraduate student-related research experiences. (Six of seven faculty responded to the survey.) Faculty reported that students assisted in the following types of research activities ¿ literature reviews; human subjects approval; data collection support that included informing agencies and potential subjects of the study, survey distribution, and recruitment of subjects; and data analysis via data entry, data cleaning and data audits. All faculty reported that their own research programs were supported by the assistance of the students and the majority of faculty and students submitted abstracts for presentation. Five of the six faculty who responded reported they would continue to participate in this activity. One faculty member perceived that leading the group of students was too labor intensive even though she had significant support and progress of her research. Overall, faculty were highly positive and expressed the desire for this type of undergraduate research activity to continue. The faculty funded to lead this initiative submitted and have been accepted to present this undergraduate initiative at a large international nursing research conference. Drs. Erlinda Wheeler and Thomas Hardie will present ¿Supporting an Embryonic Research Environment for Faculty with Undergraduate Research Students¿ at the Sigma Theta Tau International Research Conference in Summer 2006. To date, 101 students have either completed or are enrolled in an undergraduate course that increases students¿ participation in research, 10 regional poster presentations of student research, and 1 international paper presentation are outcomes of the undergraduate research initiative in nursing. Summer Undergraduate Research Internships Overview: The Delaware INBRE grant supported twenty-three undergraduate research interns in a ten-week program conducted June 6-August 12, 2005. All INBRE students participated in a three-session seminar series on clinical and translational research and research ethics, hosted by INBRE partner Christiana Care Health System. The program required students to work forty hours per week at their research assignments, and to prepare a poster or talk for an end of summer research symposium, hosted by the University of Delaware through a grant from the Howard Hughes Medical Institute. Each student was also provided a stipend, housing allowance, and when needed, transportation to required events. A number of students will continue their research projects during the academic year, and will present at poster sessions at national meetings. Institutions Involved: All five Delaware INBRE partner institutions participated in the program, as host research sites or as a source of students. This year featured an increased number of cross-institutional assignments, with nine interns (39%) conducting research at an institution other than their home institutions. During the placement process, students were asked to describe their areas of scientific interest, to review faculty research descriptions and to suggest up to four labs of interest throughout the INBRE network. Whenever possible, students were placed in one of their labs of choice. Some thirty network faculty were involved, either as research mentors or in selecting student participants from their respective institutions. For the first time in a Delaware IDeA program, the group included nursing faculty and students from the University of Delaware and Wesley College. Jeanette Miller, Research Administrator, Delaware Biotechnology Institute provided student placement and program oversight. Student Data: The diverse student group included 60% women and 30% underrepresented students (five African-American and two Hispanic students). Interns were sophomores, juniors and seniors in baccalaureate life and health science majors, including biology, chemistry, electrical and computer engineering, and nursing. Research interns also included three students involved in the two-year histotechnician program at Delaware Technical & Community College. To be candidates for an internship, students were required to have a minimum GPA of 3.00. Program Evaluation: Interns completed evaluations at the conclusion of the internship. Students reported that the internship was a very positive experience, which in many instances confirmed or catalyzed a student¿s interest in a biomedical research career. Students often reported that the internship developed or gave them confidence in some of their own skills: that they could function as a member of a lab team; that they could develop a deep understanding of a scientific project and talk about it to other scientists, which they had the opportunity to do at the end-of-summer research symposium. All INBRE students prepared scientific posters, and two INBRE students were invited to give symposium talks during the August 10, 2005 event. INBRE students also present their research at other venues, including at the Delaware INBRE EAB meeting, which took place September 19-20, 2005. Students are encouraged to apply to national meetings that host undergraduate researchers, such as the NIGMS Annual Biomedical Research Conference for Minority Students (ABRCMS) in Atlanta in November 2005. INBRE assisted three students in attending this conference. One INBRE intern (a rising senior) was offered a part-time job after summer, and was awarded an academic scholarship of $16,000 for the coming school year, an award facilitated by her internship mentors. Delaware INBRE Summer 2005 Undergraduate Research Intern Projects ¿ Purification of Euglandina and Helix DNA for Nitric Oxide Synthase Gene (Debra Barninger, Wesley College and Melissa A. Harrington, Delaware State University Department of Biological Sciences) ¿ Are Smoking Cessation Classes Beneficial or Ineffective Within a Lung Cancer Screening Program (Jamie Bartsch, Wesley College Department of Nursing; Barbara Marconi, Angela Steele-Tilton, James Lally, & Thomas Bauer, Christiana Care¿s Helen F. Graham Cancer Center) ¿ Smoking Cessation: An Opportunity to Have an Impact (Ashley Cephas, University of Delaware Department of Biological Sciences and Thomas L. Bauer, Christiana Care¿s Helen F. Graham Cancer Center) ¿ Anabolic Steroid Use Found among Teenage Physical/Sexual Abuse Victims with Longitudinal Trends (Julie M. Cullen & Thomas L. Hardie, University of Delaware School of Nursing) ¿ Development of a Laboratory Test for Unconditioned and Conditioned Fear: Light conditions and Test Duration Determines Pattern of Behavior toward Predator Odor (Cameron Davis, Delaware State University Department of Biology and Jeffrey Rosen, University of Delaware Department of Psychology) ¿ Spontaneous Baroreflex Sensitivity is Not Effected by an Acute Sodium Load (Kathleen M. DiBiase, University of Delaware School of Nursing; E.E. Paul, M.M. Wenner, A.V. Prettyman, M.E.Stillabower, M.D, & W.B. Farquhar, University of Delaware Department of Health and Exercise Sciences & Christiana Care Health Services) ¿ 3D Visualization of Volumetric Data (Allen Huang, University of Delaware Department of Biological Sciences and Karl V. Steiner, Delaware Biotechnology Institute) ¿ The Negative Predictive Value of Preoperative Combined CT and PET Scans on Diagnosing N2 Lymph Node Involvement in Lung Carcinoma (Andrew M. Farach, University of Delaware Department of Biological Sciences and Nancy Stewart, D. Bruce Panasuk, & Thomas L. Bauer, Christiana Care¿s Helen F. Graham Cancer Center) ¿ Haptic Interaction with Spring-Net Model 3D Data (Robert Forstrom & Raymond Chen, University of Delaware Department of Electrical and Computer Engineering and Karl V. Steiner, Delaware Biotechnology Institute) ¿ Risk Assessment for Lyme Disease in the State of Delaware (Xylene Graves, Arnold Omondi, Kathleen Curran, and Lynn Everett,Wesley College Department of Biology) ¿ Use of Bioinformatics Approaches to Identify Novel Cancer Biomarkers (Monica L. Holland, Delaware Technical & Community College; Ben Rohe, and Mary C. Farach-Carson, University of Delaware Department of Biological Sciences) ¿ Histotechnology: Technical Procedures (Joanne M. Kramer, Delaware Technical & Community College and Robert A. Sikes, University of Delaware Department of Biological Sciences) ¿ Cholesterol Depletion of Adipocytes and its Affect on LXR Target Genes (Marysol Lavander, Delaware Technical & Community College; John David & David Usher, University of Delaware Department of Biological Sciences) ¿ An Intervention Study: A Clinical Comparison of the Rectal Trumpet and Fecal Collector in Acutely Ill Patients with Fecal Incontinence (Elizabeth Leary and Linda Bucher, University of Delaware School of Nursing) ¿ Microarray Analysis in Mammalian Systems Using Oligonucleotides for Gene Editing (Harvard College; Luciana Ferrara, Hetal Parekh-Olmedo, & Eric B. Kmiec, University of Delaware Department of Biological Sciences and Delaware Biotechnology Institute) ¿ Correlation of the Rates of Solvolysis of IsopropylSulfonyl Chloride and 2,2,2-Trifloroethanesulfonyl Chloride (Stacey L. Mlynarski, Lamia Yaakoubd, & Malcolm J. D¿Souza, Wesley College; Dennis N. Kevill, Northern Illinois University Department of Chemistry & Biochemistry) ¿ Study of Molecular Interactions Between Cassava and Begomoviruses Infecting Cassava (Patricia Nugent, Chowda Reddy, Christian Felton, Mastingor Desir, Vincent Fondong Delaware State University Molecular, Cellular and Organismal Biology Department) ¿ The Effect of SC-2-71 on Angiogenesis in a Mouse Model (Jonathan Odle, Delaware Technical & Community College; Vesi Cooke, Ulhas Naik, Robert A. Sikes, Claire Jacklin, Michelle Hart, & Carlton R. Cooper, University of Delaware Department of Biological Sciences) ¿ BioExplorer ¿ An Immersive Tool for the real-time Exploration of three-dimensional Biomedical Datasets (Patrick Ruff, University of Delaware Department of Computer and Information Sciences and Karl V. Steiner, Delaware Biotechnology Institute) ¿ Characteristics of Individuals who Undergo Bariatric Surgery: A Review of the Database (Erin Schonewolf and Dr. Erlinda Wheeler, University of Delaware School of Nursing) ¿ Marek¿s Disease Meq Oncogene Regulation of the Host Gene Interferon (Sean Sheridan, Wesley College and Carl J. Schmidt, University of Delaware Department of Animal and Food Sciences) ¿ The Effect of G-rich Oligonucleotides on the Inhibition of Huntingtin Protein Aggregation (Michael Skogen, Hetal Parekh-Olmedo, Eric B. Kmiec, University of Delaware Department of Biological Sciences and Delaware Biotechnology Institute) ¿ Correlation of the Rates of Solvolysis of Phenylmethanesulfonyl Chloride (Lamia Yaakoubd, Stacey L. Mlynarski, & Malcolm J. D¿Souza, Wesley College Department of Chemistry and Dennis N. Kevill, Northern Illinois University Department of Chemistry & Biochemistry) New Undergraduate Laboratory Course at University of Delaware Chemistry 467-011/CHEG 467-011 (Biochemistry and Biotechnology Laboratory) Dr. Cliff Robinson, Department of Chemistry and Biochemistry, and Dr. Anne Skaja Robinson, Department of Chemical Engineering have developed a new undergraduate laboratory course in Biochemistry and Bioengineering as part of the INBRE funding. No such course has existed previously on the UD campus, and demand is great. Undergraduates in Biochemistry are required to take 6 units of laboratory in biochemistry, yet the department does not offer a biochemistry lab. In Chemical Engineering, the recent adoption of a Bioengineering minor has created great demand for courses in biochemical engineering. The new lab course has enabled students to learn basic techniques before joining a research group, and prepare them for research in graduate school or in private sector jobs after graduation. The emphasis of the course is on basic techniques in molecular biology /genetic engineering, and protein biochemistry. Students learn to cut and splice DNA, express and purify a protein, and carry out biophysical and biochemical measurements and assays. A pilot version of this course was offered in W05, and the first full version of the course ran in F06. Twelve students participated, 11 of which were chemistry and biochemistry majors. The course was very successful in that students carried out experiments in molecular biology, protein biochemistry, and biophysical methods. Although each group did not successfully produce a mutant in the gene for GFP, each group was successful in overexpressing and purifying either the wild-type or mutant version of the protein, and characterized the protein using CD and fluorescence spectroscopy. All of the students felt the course had a significant impact on expanding their classroom learning and would strongly recommend it to others. They also felt that a two-semester course would be something of value for future years.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。特拉华INBRE年度进展报告（APR） 2006拨款号2P20RR016472-2006本科生研究经验核心核心主任：Lisa Plowfield博士，特拉华大学护理学院Jeanette Miller女士，DBI研究管理员Cliff Robinson博士，特拉华大学化学和生物化学系核心目标：通过让本科生参与教师研究来加强他们的生物医学研究技能。护理学院在2005年秋季和2006年春季学期开设了NURS362：医疗保健研究概念。秋季共招收76名本科护理专业学生；2006年春季学期招收25人。所有学生都参加了护理学院的研究活动。共有7名教师研究人员领导了小组研究计划。作为这种类型的活动的结果，九张海报已经接受了由特拉华州护士协会和护理荣誉社团的学校主办的年度区域护理研究会议。以下列表列出了学生担任研究助理的项目：女性的性取向：妇科实践的决定因素。（教师发起人：Carolee Polek博士）：性取向在寻求医疗保健中的作用。（教授赞助：Carolee Polek博士）大学生上臂和前臂自动无创血压的比较。（教师赞助：Kathy Schell）：本科与非本科直接护理注册护士工作享受调查（教师赞助：琳达·布彻）教师关心的感知：关心和不关心的小片段的定性分析。（教师发起人：Gail Wade）一项关于大学生密集运动预测因素的初步研究。（教师赞助：Erlinda Wheeler & Paula Klemm）¿大学冒险与吸毒之间的联系。（教师赞助人：Tom Hardie）兄弟姐妹对糖尿病及其治疗的看法。（教师发起人：Judy Herrman）平均工作时间对护士工作乐趣的影响（教师发起人：Karen Avino）：一篇关于老年住院患者未满足需求的文献综述。（教师发起人：戴安·米克）学生的评价反应是积极和消极的混合。那些报告负面经历的学生注意到很难理解护理研究课程如何对他们的护理实践生涯有益，并且研究过程的时间密集性对他们来说并不满意。学生的反馈指出了积极的经验，他们报告说与教师在实际研究项目上的合作是有益的，小组过程是重要的，参与海报展示和出版物的研究成果是有益的。教师们被要求回答一项关于这些本科生相关研究经历的调查。（七名教师中有六名回应了这项调查。）教师报告说，学生协助进行了以下类型的研究活动：文献综述；人体受试者批准；数据收集支持，包括通知研究机构和潜在受试者，调查分发和受试者招募；通过数据输入、数据清理和数据审计进行数据分析。所有教师都报告说，他们自己的研究项目得到了学生的支持，大多数教师和学生都提交了论文摘要。在接受调查的6位教师中，有5位表示他们将继续参与这项活动。一位教师认为，尽管她的研究得到了很大的支持和进展，但带领学生小组的劳动强度太大。总的来说，教师们都非常积极，并表达了对这种本科生研究活动继续下去的愿望。资助领导这一倡议的教师提交并已被接受在一个大型国际护理研究会议上介绍这一本科生倡议。Drs。Erlinda Wheeler和Thomas Hardie将在2006年夏季的Sigma Theta Tau国际研究会议上提出“支持本科研究生教师的胚胎研究环境”。迄今为止，已有101名学生完成或注册了本科课程，这增加了学生对研究的参与，10个学生研究的区域海报展示和1个国际论文展示是护理本科研究计划的成果。本科生暑期研究实习概述：特拉华州INBRE资助在2005年6月6日至8月12日进行的为期10周的项目中资助了23名本科生研究实习生。所有INBRE学生都参加了由INBRE合作伙伴Christiana Care Health System主办的关于临床和转化研究以及研究伦理的三期系列研讨会。该项目要求学生每周工作40个小时完成他们的研究任务，并为特拉华大学通过霍华德休斯医学研究所的资助主办的夏季研究研讨会准备海报或演讲。每个学生还获得了津贴、住房津贴，必要时还提供了参加所需活动的交通工具。一些学生将在学年期间继续他们的研究项目，并将在全国会议上进行海报展示。参与机构：特拉华州INBRE的所有五个合作机构都参与了该计划，作为主办研究地点或作为学生来源。今年，跨机构任务的数量有所增加，有9名实习生（39%）在其所在机构以外的机构进行研究。在安置过程中，学生被要求描述他们感兴趣的科学领域，审查教师的研究描述，并在整个INBRE网络中建议最多四个感兴趣的实验室。只要有可能，学生们就被安排在他们选择的一个实验室里。大约有30名网络教师参与其中，要么作为研究导师，要么从各自的机构中挑选学生参与者。在特拉华IDeA项目中，该小组首次包括了来自特拉华大学和卫斯理学院的护理教师和学生。珍妮特米勒，研究管理员，特拉华生物技术研究所提供学生安置和项目监督。学生数据：多元化的学生群体包括60%的女性和30%的代表性不足的学生（五名非裔美国人和两名西班牙裔学生）。实习生是生命与健康科学专业本科二、三、四年级的学生，包括生物学、化学、电气与计算机工程、护理学。研究实习生还包括三名参加特拉华技术与社区学院为期两年的组织技术员项目的学生。要成为实习候选人，学生的平均绩点必须达到3.00。项目评估：实习生在实习结束时完成评估。学生们报告说，实习是一次非常积极的经历，在许多情况下，这证实或促进了学生对生物医学研究事业的兴趣。学生们经常报告说，实习培养了他们的一些技能，或者让他们对自己的一些技能有了信心：他们可以作为实验室团队的一员；他们可以深入了解一个科学项目，并与其他科学家讨论，他们有机会在夏末的研究研讨会上这样做。在2005年8月10日的活动中，所有INBRE学生都准备了科学海报，并邀请了两名INBRE学生进行专题演讲。INBRE的学生还在其他场所展示他们的研究成果，包括2005年9月19日至20日举行的特拉华州INBRE EAB会议。鼓励学生申请参加由本科生研究人员主持的国家会议，例如2005年11月在亚特兰大举行的NIGMS少数民族学生年度生物医学研究会议（ABRCMS）。INBRE协助三名学生参加了这次会议。一名INBRE实习生（即将升入高年级）在暑期结束后获得了一份兼职工作，并在实习导师的帮助下获得了下一学年16000美元的学术奖学金。特拉华州INBRE 2005年夏季本科研究实习生项目¿Euglandina和螺旋DNA的纯化一氧化氮合酶基因（Debra Barninger，卫斯理学院和梅丽莎a .哈林顿，特拉华州立大学生物科学系）¿戒烟课程在肺癌筛查计划中是有益的还是无效的(Jamie Bartsch，卫斯理学院护理系；芭芭拉·马可尼、安吉拉·斯蒂尔-蒂尔顿、詹姆斯·拉利和托马斯·鲍尔，克里斯蒂安娜护理中心（海伦·f·格雷厄姆癌症中心）戒烟：一个产生影响的机会（Ashley Cephas，特拉华大学生物科学系和Thomas L. Bauer, Christiana Care’s Helen F. Graham癌症中心）；在青少年身体/性虐待受害者中发现合成代谢类固醇的使用与纵向趋势（Julie M. Cullen和Thomas L. Hardie，特拉华大学护理学院）；开发无条件恐惧和条件恐惧的实验室测试：光照条件和测试时间决定了对捕食者气味的行为模式（Cameron Davis，特拉华州立大学生物系和Jeffrey Rosen，特拉华大学心理学系）自发的气压反射敏感性不受急性钠负荷的影响(Kathleen M. DiBiase，特拉华大学护理学院；E.E. Paul， M.M. Wenner， A.V. Prettyman， M.E.Stillabower, m.d., & W.B. Farquhar，特拉华大学健康与运动科学系和Christiana Care Health Services)；体积数据的三维可视化（Allen Huang，特拉华大学生物科学系和Karl V. Steiner，特拉华生物技术研究所）；术前CT和PET联合扫描对肺癌N2淋巴结累及的阴性预测价值(Andrew M. Farach，特拉华大学生物科学系和Nancy Stewart， D. Bruce Panasuk, & Thomas L. Bauer, Christiana Care & s Helen F. Graham癌症中心)；与Spring-Net模型3D数据的触觉交互（Robert Forstrom & Raymond Chen，特拉华大学电气与计算机工程系和Karl V. Steiner，特拉华生物技术研究所）；特拉华州莱姆病风险评估(Xylene Graves, Arnold Omondi, Kathleen Curran，使用生物信息学方法识别新型癌症生物标志物(Monica L. Holland，特拉华技术与社区学院；组织技术：技术程序（Joanne M. Kramer，特拉华技术与社区学院和Robert A. Sikes，特拉华大学生物科学系）脂肪细胞的胆固醇消耗及其对LXR靶基因的影响(Marysol Lavander，特拉华技术与社区学院；约翰·大卫和大卫·Usher，特拉华大学生物科学系)干预研究：直肠喇叭和粪便收集器在急性大小便失禁患者中的临床比较（Elizabeth Leary和Linda Bucher，特拉华大学护理学院）¿微阵列分析在哺乳动物系统中使用寡核苷酸进行基因编辑(哈佛大学；Luciana Ferrara, Hetal parek - olmedo, & Eric B. Kmiec，特拉华大学生物科学系和特拉华生物技术研究所)异丙基磺酰氯和2,2,2-三氟乙烷磺酰氯溶剂溶解速率的相关性(Stacey L. Mlynarski, Lamia yaakoud, & Malcolm J. D¿Souza，卫斯理学院；Dennis N. Kevill，北伊利诺斯大学化学与生物化学系);;;;;;;;;;;;;；Vesi Cooke, Ulhas Naik, Robert A. Sikes, Claire Jacklin, Michelle Hart, & Carlton R. Cooper，特拉华大学生物科学系)¿BioExplorer¿三维生物医学数据集实时探索的沉浸式工具（Patrick Ruff，特拉华大学计算机与信息科学系和Karl V. Steiner，特拉华生物技术研究所）¿接受减肥手术的个体特征：数据库综述（Erin Schonewolf和Dr. Erlinda Wheeler， University of Delaware护理学院）；Marek病Meq宿主基因干扰素的致癌基因调控（Sean Sheridan， Wesley学院和Carl J. Schmidt， University of Delaware动物和食品科学系）；富g寡核苷酸对亨廷顿蛋白聚集抑制的影响(Michael Skogen, Hetal parek - olmedo, Eric B. Kmiec，特拉华大学生物科学系和特拉华生物技术研究所)苯甲磺酰氯溶剂溶解速率的相关性(Lamia yaakoud, Stacey L. Mlynarski, & Malcolm J. D . Souza，韦斯利学院化学系和Dennis N. Kevill，特拉华大学化学467-011/CHEG 467-011（生物化学和生物技术实验室）化学和生物化学系的Cliff Robinson博士和化学工程系的Anne Skaja Robinson博士开发了一门新的生物化学和生物工程本科实验课程，作为INBRE资助的一部分。以前在特拉华大学校园里没有这样的课程，需求很大。生物化学系本科生必须修6个单元的生物化学实验课，但本系不开设生物化学实验课。在化学工程中，最近采用生物工程辅修课程创造了对生化工程课程的巨大需求。新的实验课程使学生能够在加入研究小组之前学习基本技术，并为他们毕业后在研究生院或私营部门的研究工作做好准备。本课程的重点是分子生物学/基因工程和蛋白质生物化学的基本技术。学生学习切割和剪接DNA，表达和纯化蛋白质，并进行生物物理和生化测量和分析。本课程的试点版本于2005年推出，第一个完整版本于2006年推出。12名学生参与其中，其中11名是化学和生物化学专业的学生。这门课程非常成功，学生们进行了分子生物学、蛋白质生物化学和生物物理方法的实验。虽然每个组都没有成功地产生GFP基因的突变体，但每个组都成功地过表达和纯化了野生型或突变型的蛋白质，并使用CD和荧光光谱对蛋白质进行了表征。所有的学生都认为这门课程对扩大他们的课堂学习有很大的影响，并强烈推荐给其他人。他们还觉得，两个学期的课程对未来几年很有价值。