Northern Plains Center for Behavioral Research Translation

描述（由申请人提供）：这个拟议的北方平原研究翻译中心（NPCRT）的目标是在北达科他州大学创建一个多学科的临床和翻译研究综合计划，为整个地区的高危农村人口提供服务。NPCRT的目标是开发，测试和传播干预措施和最佳实践，以解决经常可预防的行为介导的生理疾病，如肥胖和糖尿病，神经退行性疾病，如阿尔茨海默氏症和帕金森氏症，以及行为障碍，如抑郁症和自杀。这些疾病不成比例地影响到我们区域最弱势的人-美洲印第安人、老年农村穷人、妇女和儿童。NPCRT将通过提供临床和转化科学的研究生学位，为职业发展的各个阶段的研究人员提供服务，并提供研究培训。该CTSA项目的具体目标是创建：1）临床和转化研究作为UNO学科的发展计划; 2）研究教育，培训和职业发展计划; 3）需求分析，以确定 CTSA将开发和提供的专业知识和资源; 4）CTSA组织计划， 管理、治理和评估; 5）CTSA高级领导选拔计划; 6） 确保有足够的空间和设施; 7）计划对当地资金和机构的坚定承诺 支持; 8）保证科学质量的计划;和9）发展合作和传播的计划。我们的转型愿景是规划一个创新的，分布式的，农村的CTSA模式，由我们人民的健康需求驱动。肥胖症已经飙升-62%的ND成年人现在超重或肥胖。从1994年到2003年，ND中2型糖尿病患病率跃升了72%。神经退行性疾病（阿尔茨海默氏症和帕金森氏症）越来越普遍。ND的美国印第安青年自杀率比白人青年高429%。需要制定和传播新的干预措施和最佳做法，以降低这些疾病的发病率和死亡率。我们必须解决这些医疗保健需求，以及这些弱势群体与其他群体之间存在的健康状况差异，因此我们呼吁提供资金，计划建立一个北方平原研究翻译中心。

DESCRIPTION (provided by applicant): The goal of this proposed Northern Plains Center for Research Translation (NPCRT) is to create a multidisciplinary, integrated program of clinical and translational research at the University of North Dakota that serves at-risk rural populations across the region. The NPCRT's objective is to develop, test, and disseminate interventions and best practices that address often-preventable behaviorally mediated physiologic disorders such as obesity and diabetes, neuro-degenerative disorders such as Alzheimer's and Parkinson's, and behavioral disorders such as depression and suicide. These diseases disproportionately affect the most disadvantaged people in our region-American Indians, the elderly rural poor, women and children. The NPCRT will serve investigators at all stages of career development by offering graduate degrees in the clinical and translational sciences, and provide research training. The specific aims of this CTSA project are to create: 1) plans for the development of clinical and translational research as a discipline at UNO; 2) plans for research education, training, and career development; 3) a needs analysis to determine the expertise and resources that the CTSA will develop and offer; 4) a plan for CTSA organization, administration, governance, and evaluation; 5) a plan for CTSA senior leadership selection; 6) a plan to assure adequate space and facilities; 7) plans for firm commitments for local funding and institutional support; 8) a plan to assure scientific quality; and 9) a plan to develop collaborations and dissemination. Our transformational vision is to plan an innovative, distributed, rural CTSA model driven by the health needs of our people. Obesity has skyrocketed-62% of ND adults are now overweight or obese. Type 2 diabetes prevalence in ND jumped 72% from 1994 to 2003. Neurodegenerative disorders (Alzheimer's and Parkinson's) are increasingly prevalent. American Indian youth in ND die by suicide at a rate 429% higher than that for young whites. Development and dissemination of new interventions and best practices is needed to reduce morbidity and mortality from these diseases. We must address these health care needs, as well as the disparities in health status that exist between these vulnerable groups and others, thus our appeal for funding to plan a Northern Plains Center for Research Translation.