Perinatal risk factors and genetic susceptibility for childhood psychopathology

儿童精神病理学的围产期危险因素和遗传易感性

• 批准号: 7532184
• 负责人: Yoko Nomura
• 金额: $ 17.66万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-18 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7532184
• 关键词: Accounting; Adult; Affect; Age; Alcohol or Other Drugs use; Amniocentesis; Anxiety; Anxiety Disorders; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Birth; Birth Records; Birth Weight; Child; Child Development; Childhood; Clinical; Cognitive deficits; Collection; Communities; Data; Data Collection; Databases; Development; Diagnostic; Discipline; Disease; Disease remission; Disruptive Behavior Disorder; Distal; Drops; Educational process of instructing; Educational workshop; Emotional; Enrollment; Environment; Epidemiologic Studies; Epigenetic Process; Etiology; Event; Exhibits; Family; Follow-Up Studies; Fright; Future; Generalized Anxiety Disorder; Genetic; Genetic Predisposition to Disease; Genetic Risk; Goals; Heritability; Hyperactive behavior; Impairment; Incidence; Infant; Infant Mortality; Intervention; Interview; K-Series Research Career Programs; Learning; Length; Longevity; Longitudinal Studies; Low Birth Weight Infant; Measures; Mediator of activation protein; Medical Records; Medicine; Mental Depression; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Monitor; Morbidity - disease rate; Nature; Neonatal Intensive Care; Neonatal Intensive Care Units; Neonatal Mortality; New England; Outcome; Panic Disorder; Pathway interactions; Perinatal; Perinatal Epidemiology; Pregnancy; Pregnancy Outcome; Premature Birth; Principal Investigator; Problem behavior; Psychiatry; Psychopathology; Psychosocial Stress; Public Health; Purpose; Range; Rate; Recording of previous events; Recurrence; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Sampling; Schools; Scientist; Series; Social Phobia; Societies; Structure; Survivors; Symptoms; Temperament; Testing; Training; Training Activity; Training Programs; Traumatic Stress Disorders; Week; Work; base; cohort; cost; early childhood; epidemiological model; experience; fetal; functional disability; genetic risk factor; high school; improved; in utero; inattention; modifiable risk; mortality; multidisciplinary; outcome forecast; prenatal; prenatal risk factor; programs; psychogenetics; psychologic; social; statistics

DESCRIPTION (provided by applicant): A notable recent advance in psychiatry is the recognition that mental health problems can originate in-utero. Research in developmental psychopathology has shown that preterm birth is associated with a 2- to 3-fold increased risk of both disruptive behavior and anxiety disorders. However, no prior studies have examined why preterm birth is associated with a wide range of childhood disorders. Furthermore, few studies have integrated models based on research in perinatal epidemiology and psychiatric genetics to understand the trajectory of developmental psychopathology. The purpose of this Mentored Research Scientist Development Award (K01) is to support the development of the candidate to become an independent scientist whose work will focus on the impact of modifiable prenatal predictors on mental illness, taking into account genetic influences. To achieve this goal, the candidate's multidisciplinary group of mentors will teach her specific methods for studying fetal/child development and psychiatric genetics, and guide her selection of coursework. For the candidate successfully integrate these disparate scientific disciplines, the team of mentors will actively monitor and review the candidate's progress. The research plan was significantly refined and simplified, and proposes a program of research comprised of two related studies: 1) a longitudinal epidemiologic study of 2,022 children who were enrolled in the National Collaborative Perinatal Study - New England and followed into adulthood and 2) a longitudinal study of 225 children at high and low risk for Attention Deficit Hyperactivity Disorder. Two competing hypotheses will be tested: (1) that different causes of preterm birth independently influence the risk of disruptive behavior and anxiety disorders; and (2) that preterm birth, regardless of its cause, interacts with genetic susceptibility to directly increase the risk for each disorder. In this revised application, genetic and epigenetic training at Jackson Lab is proposed in a place of the additional longitudinal statistics workshop. As a part of the training, the candidate will conduct retrospective data collection to gather supplemental information on the early developmental environment during pregnancy while maximizing the infrastructure available in the second study. This research has significant public health implications in helping to elucidate the developmental, biological, and genetic pathways through which childhood disorders develop. Subsequent identification of very early modifiable risk factors for childhood disorders will create new possibilities for earlier and more effective interventions. This may help relieve the burden in families with young children exhibiting psychopathology by informing new treatment approaches for young children. Together, this research and training program will effect the candidate's transition to independence as an investigator and will contribute greatly to our understanding of modifiable risk factors for disruptive behavior and anxiety disorders for planning and testing future interventions.

描述（由申请人提供）：精神病学最近的一个显著进展是认识到精神健康问题可能起源于子宫内。发展精神病理学的研究表明，早产与破坏性行为和焦虑症的风险增加2至3倍有关。然而，之前没有研究调查为什么早产与广泛的儿童疾病有关。此外，很少有研究将围产期流行病学和精神遗传学研究相结合的模型来理解发育性精神病理学的发展轨迹。