The Evolutionary Basis of the Developmental Course and Etiologies of Anxiety and Disruptive Behaviors during Early Adolescence

青春期早期焦虑和破坏性行为的发展过程和病因的进化基础

• 批准号: 10737103
• 负责人: Yoko Nomura
• 金额: $ 78.07万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737103
• 关键词: Acceleration; Adolescence; Adolescent; Age; Aggressive behavior; Amygdaloid structure; Anxiety; Area; Back; Behavior; Behavioral; Behavioral Symptoms; Biological; Birth; Brain; Buffers; COVID-19 pandemic; Child; Child Rearing; Childhood; Clinical; Cluster Analysis; Complement; Data Collection; Data Set; Development; Developmental Course; Diagnostic; Diffusion; Disease; Disruptive Behavior Disorder; Emotional; Environment; Etiology; Exposure to; Face; Family; Fright; Goals; Growth; Hair; Hippocampus; Individual; Individual Differences; Intervention; Interview; Life; Link; Measurable; Measures; Mediating; Mental Depression; Mental Health; Minority; Modeling; Mothers; Multimodal Imaging; National Institute of Mental Health; Natural Disasters; Natural experiment; Nature; Negative Valence; New York; Organ; Outcome; Participant; Phenotype; Population; Positioning Attribute; Pregnancy; Pregnant Women; Preparation; Protocols documentation; Psychopathology; Psychosocial Stress; Puberty; Quasi-experiment; Race; Random Allocation; Randomized; Regulation; Research Domain Criteria; Rest; Risk; Role; Sampling; Sex Differences; Signal Transduction; Source; Specimen; Stress; Structure; Surface; Symptoms; System; Testing; Thick; Time; United States National Institutes of Health; Work; behavior measurement; behavioral outcome; behavioral phenotyping; boys; childhood adversity; cognitive control; cohort; comorbidity; comparison control; coronavirus disease; early adolescence; early onset; fetal; fetal programming; follow up assessment; girls; gray matter; hazard; high risk; in utero; indexing; longitudinal analysis; low socioeconomic status; neural; neuroadaptation; neurobehavior; neurobehavioral; neuroimaging; neuromechanism; offspring; pandemic disease; pandemic impact; pandemic stress; postnatal; predictive modeling; preempt; prenatal; prenatal exposure; prenatal influence; prenatal stress; prospective; psychosocial; public health relevance; random forest; rate of change; recruit; repository; response; sex; sexual dimorphism; socioeconomics; stressor; substance use; symptomatology; white matter

Summary/Abstract: Accumulating evidence, including our own, indicates that in utero exposure to psychosocial stress is associated with risks for elevated anxiety (ANX) and disruptive behavior (DB) symptomatology. In this application, we will build on our existing birth cohort of children exposed and unexposed to Superstorm Sandy (SS) in utero. SS randomly “assigned” stressful conditions to pregnant women and their offspring in our cohort, giving us a unique opportunity to conduct a quasi-experiment of in utero stress. Using our deeply phenotyped cohort, we propose to investigate whether in utero SS exposure modulates the impact of the postnatal stressful environment, either amplifying (double-hit acceleration model) or shielding (stress inoculation model) the effects of postnatal stress on ANX and DB symptomatology. We will continue to measure different types of postnatal stress (normative, poor parenting, and COVID-related) to examine if magnitude, nature, timing and duration of the postnatal stressors influences the direction and impact on such symptomatology. As well as the DSM-based diagnostic outcomes, we will utilize the NIMH RDoC and focus on Negative Valence and Cognitive Control Systems (NVS/CCS), which will enable a transdiagnostic perspective of pre- and postnatal stress-related changes in behavior and the brain. Following our prior work, we will also examine sex-specific manifestations of the behavioral phenotypes (more internalizing problems in girls and more externalizing in boys) and explore the moderating role of SES when intersecting with individual differences in behaviors. As the brain is the central modulatory organ of stress/adaptation and regulation, we will use neuroimaging to assess changes in brain structure, function, and connectivity in limbic-frontal circuitry during early pre- and post-puberty, using a subsample of our cohort. Our cohort was followed from in utero, with completed follow-up assessments (neurobehavioral, clinical, and biological specimens), which will continue as they enter pre/puberty (ages 9-13), a time of peak risks for such problems and sex-dimorphism. Specifically, we will: 1) examine the effects of SS-related stress and the postnatal psychosocial environment on trajectories of clinical and adaptive neurobehaviors; 2) study the impact of prenatal SS stress and postnatal stress on NVS/CCS brain outcomes (structure and function) and evaluate the extent to which NVS/CCS structural changes mediate between prenatal SS-exposure and child anxiety and DB symptoms; and 3) develop predictive models for NVS/CCS outcomes in early adolescence based on biological and behavioral measures obtained in utero and/or the first decade of the child’s life. As pre/puberty is an important period of developmental transition and heightened risk for ANX and DB, we will build on our unique repository of both clinical and stored hair samples and continue to chart children’s neurobehavioral development and risk for psychopathology through ages 9-13. Together with the inclusion of neuroimaging to investigate neural mechanisms centered on the NVS/CCS and using tasks from the ABCD study, our study is uniquely positioned to elucidate the mechanisms of fetal programing and threat sensitivity in the NVS/SSV that modulate the risks for anxiety and reactive aggression.

总结/摘要：越来越多的证据，包括我们自己的证据，表明在子宫内暴露于心理社会 压力与焦虑升高（ANX）和破坏性行为（DB）的风险相关。在这 应用程序，我们将建立在我们现有的出生队列的儿童暴露和未暴露于超级风暴桑迪（SS） 在子宫里在我们的队列中，SS随机将压力条件“分配”给孕妇及其后代， 我们有一个独特的机会来进行准实验的子宫压力。使用我们的深度表型队列，我们 建议调查子宫内SS暴露是否调节产后应激环境的影响， 要么放大（双重打击加速模型）要么屏蔽（应激接种模型）产后的影响 强调ANX和DB血管学。我们将继续测量不同类型的产后压力（规范， 不良养育和COVID相关），以检查产后压力源的大小，性质，时间和持续时间 影响了这种传播学的方向和影响。除了基于DSM的诊断结果之外，我们 将利用NIMH RDoC，并专注于负价和认知控制系统（NVS/CCS），这将 使一个transdiagnosis的角度产前和产后压力相关的变化，在行为和大脑。 在我们之前的工作之后，我们还将检查行为表型的性别特异性表现（更多 女孩的内化问题和男孩的外化问题），并探讨SES的调节作用， 与行为的个体差异相交。由于大脑是大脑的中枢调节器官， 压力/适应和调节，我们将使用神经成像来评估大脑结构，功能和 连接在边缘额叶电路在青春期前和青春期后早期，使用我们的队列的子样本。我们 队列从子宫内开始随访，完成随访评估（神经行为、临床和生物学 样本），这将继续，因为他们进入前/青春期（9-13岁），一个高峰期的风险，这些问题， 两性异形具体而言，我们将：1）研究SS相关压力和产后心理社会的影响 环境对临床和适应性神经行为轨迹的影响; 2）研究产前SS压力的影响， 产后应激对NVS/CCS脑结果（结构和功能）的影响，并评估NVS/CCS 产前SS暴露与儿童焦虑和DB症状之间的结构变化介导;和3）发展 基于生物和行为测量的青春期早期NVS/CCS结果预测模型 在子宫内和/或孩子生命的第一个十年获得。由于青春期前是发育的重要时期， 由于ANX和DB的过渡和风险增加，我们将建立在我们独特的临床和储存库基础上， 头发样本，并继续图表儿童的神经行为发展和精神病理学的风险， 9-13岁。连同神经影像学的纳入，以研究神经机制为中心的 NVS/CCS和使用ABCD研究的任务，我们的研究是独特的定位，以阐明机制， NVS/SSV中的胎儿编程和威胁敏感性调节焦虑和反应性攻击的风险。