Perinatal risk factors and genetic susceptibility for childhood psychopathology

儿童精神病理学的围产期危险因素和遗传易感性

• 批准号: 7689141
• 负责人: Yoko Nomura
• 金额: $ 1.5万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-18 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689141
• 关键词: Accounting; Adult; Affect; Age; Amniocentesis; Anxiety; Anxiety Disorders; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Birth; Birth Weight; Child; Child Development; Childhood; Clinical; Cognitive deficits; Collection; Communities; Data; Data Collection; Databases; Development; Diagnostic; Discipline; Disease; Disease remission; Disruptive Behavior Disorder; Distal; Drops; Educational process of instructing; Educational workshop; Emotional; Enrollment; Environment; Epidemiologic Studies; Epigenetic Process; Etiology; Event; Exhibits; Family; Follow-Up Studies; Fright; Future; Generalized Anxiety Disorder; Genetic; Genetic Predisposition to Disease; Genetic Risk; Goals; Heritability; Hyperactive behavior; Impairment; Incidence; Infant; Infant Mortality; Intervention; Interview; K-Series Research Career Programs; Learning; Length; Longevity; Longitudinal Studies; Low Birth Weight Infant; Measures; Mediator of activation protein; Medical Records; Medicine; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Monitor; Morbidity - disease rate; Nature; Neonatal Intensive Care; Neonatal Intensive Care Units; Neonatal Mortality; New England; Outcome; Panic Disorder; Pathway interactions; Perinatal; Perinatal Epidemiology; Post-Traumatic Stress Disorders; Pregnancy; Pregnancy Outcome; Premature Birth; Principal Investigator; Problem behavior; Psychiatry; Psychopathology; Psychosocial Stress; Public Health; Recording of previous events; Recurrence; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Sampling; Schools; Scientist; Series; Social Phobia; Societies; Structure; Survivors; Symptoms; Temperament; Testing; Training; Training Activity; Training Programs; Work; base; cohort; cost; depression; early childhood; effective intervention; epidemiological model; experience; fetal; functional disability; genetic risk factor; high school; improved; in utero; inattention; modifiable risk; mortality; multidisciplinary; outcome forecast; prenatal; prenatal risk factor; programs; psychogenetics; psychologic; social; statistics

DESCRIPTION (provided by applicant): A notable recent advance in psychiatry is the recognition that mental health problems can originate in-utero. Research in developmental psychopathology has shown that preterm birth is associated with a 2- to 3-fold increased risk of both disruptive behavior and anxiety disorders. However, no prior studies have examined why preterm birth is associated with a wide range of childhood disorders. Furthermore, few studies have integrated models based on research in perinatal epidemiology and psychiatric genetics to understand the trajectory of developmental psychopathology. The purpose of this Mentored Research Scientist Development Award (K01) is to support the development of the candidate to become an independent scientist whose work will focus on the impact of modifiable prenatal predictors on mental illness, taking into account genetic influences. To achieve this goal, the candidate's multidisciplinary group of mentors will teach her specific methods for studying fetal/child development and psychiatric genetics, and guide her selection of coursework. For the candidate successfully integrate these disparate scientific disciplines, the team of mentors will actively monitor and review the candidate's progress. The research plan was significantly refined and simplified, and proposes a program of research comprised of two related studies: 1) a longitudinal epidemiologic study of 2,022 children who were enrolled in the National Collaborative Perinatal Study - New England and followed into adulthood and 2) a longitudinal study of 225 children at high and low risk for Attention Deficit Hyperactivity Disorder. Two competing hypotheses will be tested: (1) that different causes of preterm birth independently influence the risk of disruptive behavior and anxiety disorders; and (2) that preterm birth, regardless of its cause, interacts with genetic susceptibility to directly increase the risk for each disorder. In this revised application, genetic and epigenetic training at Jackson Lab is proposed in a place of the additional longitudinal statistics workshop. As a part of the training, the candidate will conduct retrospective data collection to gather supplemental information on the early developmental environment during pregnancy while maximizing the infrastructure available in the second study. This research has significant public health implications in helping to elucidate the developmental, biological, and genetic pathways through which childhood disorders develop. Subsequent identification of very early modifiable risk factors for childhood disorders will create new possibilities for earlier and more effective interventions. This may help relieve the burden in families with young children exhibiting psychopathology by informing new treatment approaches for young children. Together, this research and training program will effect the candidate's transition to independence as an investigator and will contribute greatly to our understanding of modifiable risk factors for disruptive behavior and anxiety disorders for planning and testing future interventions.

描述（由申请人提供）：精神病学最近的一个显著进展是认识到精神健康问题可能起源于子宫内。发展性精神病理学的研究表明，早产与破坏性行为和焦虑症的风险增加2至3倍有关。然而，没有先前的研究探讨了为什么早产与广泛的儿童疾病有关。此外，很少有研究整合模型的基础上，在围产期流行病学和精神遗传学的研究，以了解发展的精神病理学的轨迹。 这个指导研究科学家发展奖（K 01）的目的是支持候选人的发展，成为一个独立的科学家，其工作将集中在修改产前预测对精神疾病的影响，考虑到遗传的影响。为了实现这一目标，候选人的多学科导师小组将教她学习胎儿/儿童发育和精神遗传学的具体方法，并指导她选择课程。为了让候选人成功整合这些不同的科学学科，导师团队将积极监控和审查候选人的进展。 该研究计划进行了显著的改进和简化，并提出了一项由两项相关研究组成的研究计划：1）对参加国家围产期合作研究-新英格兰并随访至成年的2，022名儿童进行的纵向流行病学研究; 2）对225名注意缺陷多动障碍高风险和低风险儿童进行的纵向研究。将检验两个相互竞争的假设：（1）早产的不同原因独立影响破坏性行为和焦虑症的风险;（2）早产，无论其原因如何，与遗传易感性相互作用，直接增加每种疾病的风险。在这个修订后的申请，遗传和表观遗传训练在杰克逊实验室提出了一个额外的纵向统计研讨会的地方。作为培训的一部分，候选人将进行回顾性数据收集，以收集有关怀孕期间早期发育环境的补充信息，同时最大限度地利用第二项研究中可用的基础设施。这项研究具有重要的公共卫生意义，有助于阐明儿童疾病发展的发育，生物和遗传途径。随后确定儿童期疾病的早期可改变的风险因素，将为更早和更有效的干预创造新的可能性。这可能有助于减轻家庭的负担，幼儿表现出精神病理学，为幼儿提供新的治疗方法。 总之，这项研究和培训计划将影响候选人的过渡到独立作为一个调查员，并将大大有助于我们的破坏性行为和焦虑症的可修改的风险因素的理解，为规划和测试未来的干预措施。