Perinatal risk factors and genetic susceptibility for childhood psychopathology

儿童精神病理学的围产期危险因素和遗传易感性

• 批准号: 8012359
• 负责人: Yoko Nomura
• 金额: $ 10.8万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-11-23 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8012359
• 关键词: Accounting; Address; Adult; Age; Amniocentesis; Anxiety; Anxiety Disorders; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Birth; Birth Weight; Characteristics; Child; Child Development; Childhood; Chronic; Clinical; Clinical Research; Cognitive; Communities; Data; Data Analyses; Data Collection; Development; Diagnostic; Discipline; Disease; Disruptive Behavior Disorder; Drops; Educational process of instructing; Emotional; Enrollment; Environment; Epidemiologic Studies; Etiology; Exhibits; Family; Follow-Up Studies; Fright; Future; Genetic; Genetic Predisposition to Disease; Goals; Heritability; Hyperactive behavior; Impairment; Incidence; Infant Mortality; Intervention; Interview; Investigation; K-Series Research Career Programs; Learning; Length; Life Cycle Stages; Longitudinal Studies; Low Birth Weight Infant; Measures; Medicine; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Monitor; Morbidity - disease rate; Mothers; Neonatal Intensive Care; Neonatal Intensive Care Units; Neonatal Mortality; New England; Outcome; Panic Disorder; Pathway interactions; Perinatal; Perinatal Epidemiology; Post-Traumatic Stress Disorders; Pregnancy; Pregnancy Outcome; Premature Birth; Problem behavior; Psychiatry; Psychopathology; Public Health; Recording of previous events; Relative (related person); Reporting; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Risk Factors; Sampling; Schools; Scientist; Social Phobia; Societies; Structure; Survivors; Technology; Testing; Training; Training Activity; Training Programs; Ultrasonography; Work; base; cohort; cost; depression; design; early childhood; effective intervention; epidemiological model; experience; fetal; high school; improved; in utero; inattention; modifiable risk; mortality; multidisciplinary; outcome forecast; prenatal; programs; psychogenetics; psychologic; social

DESCRIPTION (provided by applicant): One remarkable recent advance in psychiatry is the recognition that mental health problems can originate in utero. Research in developmental psychopathology has shown that preterm birth (PTB) is associated with a 2- to 3-fold increased risk of both disruptive behavior and anxiety disorders. However, no prior studies have examined why PTB is associated with a wide range of childhood disorders. Furthermore, few studies have integrated models based on research in perinatal epidemiology and psychiatric genetics to understand the trajectory of developmental psychopathology. The purpose of this Mentored Research Scientist Development Award (K01) is to support the development of the candidate to an independent scientist, whose work will be devoted to the examination of perinatal problems that are related to modifiable prenatal predictors of mental illness, taking into account genetic influences. To achieve this goal, in this revised application, the candidate has strengthened her multidisciplinary group of mentors reflecting a more focused program of research. They will teach her specific methods for studying fetal/child development and psychiatric genetics, and monitor her coursework. For the candidate to have a successful integration of apparently disparate disciplines, plans for the team of mentors to monitor and review the candidate's progress have been put in place. As suggested in the previous set of reviews, the research plan was significantly refined and simplified to test two competing hypotheses: (1) that different causes of PTB independently influence the risk of disruptive and anxiety disorders; and (2) that PTB, regardless of its cause, interacts with genetic susceptibility to directly increase the risk for each disorder. The research plan proposes a program of research comprised two related studies: 1) a longitudinal epidemiologic study of 2,022 children (Study 1) who were enrolled in the National Collaborative Perinatal Study - NewEngland and followed into adulthood and 2) a longitudinal study of 225 children at high and low risk for Attention Deficit Hyperactivity Disorder (Study2). Additionally, retrospective data collection of early developmental environment during pregnancy from mothers is included, where the candidate will collect her own data to test her hypotheses maximizing the infrastructure available in Study 2. This research has significant public health implications. First, it will help elucidate the developmental, biological, and genetic pathways through which childhood disorders develop. Subsequent identification of very early modifiable risk factors for childhood disorders will create new possibilities for earlier and more effective interventions. That may help relieve the burden in families with young children who have developmental psychopathology as well as providing new possibilities for treatment of the children themselves. Together, the research and training program are central to the candidate's transition to independence as an investigator and will contribute greatly to our understanding of modifiable risk factors for disruptive and anxiety disorders for future interventions.

描述（由申请人提供）：精神病学上的一个显着进步是认识到心理健康问题可能起源于子宫。发育心理病理学的研究表明，早产（PTB）与破坏性行为和焦虑症的风险增加了2至3倍。但是，没有先前的研究研究了为什么PTB与多种儿童疾病有关。此外，很少有研究基于围产期流行病学和精神遗传学研究的研究模型，以了解发育心理病理学的轨迹。这项受过指导的研究科学家发展奖（K01）的目的是支持候选人向独立科学家的发展，其工作将专门研究与遗传学影响相关的与可修改的精神疾病产前预测指标有关的围产期问题。为了实现这一目标，在经过修订的应用程序中，候选人加强了她的多学科导师小组，反映了更为专注的研究计划。他们将教她研究胎儿/儿童发育和精神遗传学的特定方法，并监测她的课程。为了使候选人成功地整合了明显不同的学科，为导师团队监视和审查候选人的进度的计划已达到位。如前一组评论中所建议，研究计划得到了显着完善和简化，以检验两个相互竞争的假设：（1）PTB的不同原因独立影响破坏性和焦虑症的风险； （2）PTB无论其原因如何，都与遗传敏感性直接增加了每种疾病的风险。该研究计划提出了一项研究计划，其中包括两项相关研究：1）对2,022名儿童（研究1）进行的纵向流行病学研究（研究1），这些儿童已入学，这些儿童已入学 - 纽安格兰（Newengland），并遵循了纽格兰（Newengland），并遵循225名儿童的纵向研究，对注意力不足和低风险进行了缺乏障碍的超活动障碍（研究2）。此外，还包括母亲怀孕期间早期发育环境的回顾性数据收集，候选人将收集自己的数据以测试她的假设，以最大程度地提高研究2中可用的基础设施。这项研究具有重大的公共卫生影响。首先，它将有助于阐明儿童疾病发展的发育，生物学和遗传途径。随后确定儿童疾病的非常早期的可修改风险因素将为早期和更有效的干预措施创造新的可能性。这可能有助于减轻患有发育心理病理学的幼儿家庭的负担，并提供新的可能性来治疗孩子自己。共同研究和培训计划是候选人向独立转变为研究者的核心，并将为我们对可修改的风险因素的理解做出很大的贡献，以实现未来干预措施的破坏性和焦虑症。