Intervention Development: Reducing HIV Risk in Vulnerable Youth

干预措施的制定：降低弱势青少年的艾滋病毒风险

基本信息

批准号：
7496014
负责人：
Robert Garofalo
金额：
$ 22.02万
依托单位：
LURIE CHILDREN'S HOSPITAL OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-13 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7496014
关键词：
20 year old AIDS prevention AIDS/HIV problem Adolescence Adolescent Adult African American Age Alcohol consumption Alcohol or Other Drugs use Alcohols Attitude Behavior Therapy Behavioral Belief Centers for Disease Control and Prevention (U.S.)Communities Consent Control Groups Data Data Analyses Decision Making Development Discrimination Drug usage Educational Curriculum Effectiveness of Interventions Equilibrium Esthesia Feedback Funding Future Goals Guidelines HIV HIV Infections Health Homelessness Human immunodeficiency virus test Internet Intervention Intervention Studies Intervention Trial Knowledge Latino Life Literature Loneliness Mental Depression Mental disorders Mentally Ill Persons Methods Minority Modeling Outcome Participant Partner Communications Personal Attribute Pharmaceutical Preparations Phase Population Population Study Preparation Prevention program Primary Prevention Procedures Prophylactic treatment Psychological Stress Randomized Controlled Trials Rate Recruitment Activity Research Design Risk Risk Behaviors Risk-Taking Sample Size Sampling Sex Behavior Sexual Partners Sexually Transmitted Diseases Site Specific qualifier value Staging Street Youths Stress Substance abuse problem Suggestion Target Populations Teenagers Testing Well in self Work Youth base cohort condoms design emotion regulation experience follow-up high risk sexual behavior information gathering inner city innovation men who have sex with men peer pressure prevent programs psychosocial racial and ethnic runaway youth self esteem sex size skills social social cognitive theory therapy development tool treatment effect young adult

项目摘要

DESCRIPTION (provided by applicant): This exploratory/developmental application (R34) requests funds to design and pilot an HIV and substance use prevention program for 16-20 year-old ethnically-diverse, young men who have sex with men (YMSM). We will combine and adapt three innovative HIV and substance use prevention programs originally developed for adult MSM (Project MIX), runaway youth (Street Smart), and mentally ill adolescents (Project BALANCE). Project MIX is a federally-funded behavioral intervention for MSM who use drugs/alcohol. Street Smart is in the CDC compendium of empirically supported HIV prevention programs. Project BALANCE is an ongoing HIV prevention program for teens with psychiatric disorders. In stage 1, we will work with our advisory board and gather information from key young adult HIV+ MSM informants (N=21) to develop a uniquely tailored manualized intervention for YMSM drawing on Project MIX, Street Smart, and Project BALANCE. In stage 2, we will pilot test the intervention with cohort 1 -- a community-based sample of 20 ethnically-diverse YMSM (2 groups of 10 YMSM). We will examine the intervention's feasibility, acceptability and tolerability, and we will evaluate our tracking and retention strategies. We will refine the curriculum and study procedures based on participant feedback and advisory board input. In stage 3, we will test the revised intervention in a pilot randomized controlled trial (RCT) in a sample of 100 YMSM (cohort 2) - 50 YMSM in the experimental group and 50 YMSM in a control group. Cohort 1 will complete baseline and 3-month follow-up assessments to evaluate tracking and retention strategies. Cohort 2 will complete baseline, 3-, and 6-month follow-up to evaluate preliminary treatment effects. The intervention will be informed by social learning theory and a social- personal framework previously applied to the sexual and drug use behavior of at-risk youth. The intervention will target key determinants of risk taking among our specific population of YMSM, including: psychological well- being and emotion regulation, personal attributes, peer and partner relationships, sexual context variables, and sexual minority stress. Data analyses will (a) evaluate change in adolescent risky sexual behavior and substance abuse as a function of program participation, and (b) determine the pretest-posttest effect size of program impact on the outcome variables. We will use the effect size to determine the sample size needed for a more definitive test of the intervention in the future. Our target population, young men who have sex with men age 16-20, is one of the highest U.S. risk groups for HIV/AIDS acquisition, yet one that is woefully under-represented in the intervention literature. Empowered with the right tools, YMSM will be better equipped to make decisions that reduce the spread of HIV. Consistent with R34 guidelines to support the early phase of intervention development and pilot testing, the final product will form the basis for a full-scale intervention trial for YMSM. This study is part of an overall program of research designed to understand and prevent HIV infection among high-risk youth.

描述（由申请人提供）：此探索/发育应用程序（R34）要求为16-20岁的种族多样性，与男性发生性关系的年轻人（YMSM）设计和驾驶艾滋病毒和药物预防计划。我们将结合并适应最初为成人MSM（项目组合），失控青年（街头智能）和精神疾病的青少年（项目平衡）开发的三种创新艾滋病毒和药物使用预防计划。项目组合是使用药物/酒精的MSM的联邦资助行为干预。 Street Smart正在经验支持的艾滋病毒预防计划的CDC汇编中。项目平衡是针对患有精神疾病的青少年的持续预防艾滋病毒预防计划。在第1阶段，我们将与我们的顾问委员会合作，并从关键的年轻成人艾滋病毒+ MSM线人（n = 21）中收集信息，以开发出独特的量身定制的手动干预，用于YMSM，以了解项目组合，街头智能和项目平衡。在第2阶段中，我们将试行与同类1的干预措施 - 基于社区的20个种族多样性YMSM（2组为10 YMSM）的样本。我们将研究干预措施的可行性，可接受性和耐受性，并将评估我们的跟踪和保留策略。我们将根据参与者的反馈和顾问委员会的意见来完善课程和研究程序。在第3阶段，我们将在实验组的100 YMSM（同类群体2）-50 YMMM的样本中测试一项试验随机对照试验（RCT）的修订干预措施，对照组为50 YMSM。队列1将完成基线和3个月的随访评估，以评估跟踪和保留策略。队列2将完成基线，3个月和6个月的随访，以评估初步治疗效果。这项干预将由社会学习理论和以前应用于处于危险中的年轻人的性和毒品使用行为的社会个人框架来告知。干预措施将针对我们特定的YMSM人群中冒险的关键决定因素，包括：心理健康和情感调节，个人属性，同伴和伴侣关系，性背景变量以及性少数群体压力。数据分析将（a）评估青少年风险的性行为和滥用药物的变化，以及（b）确定程序的预测试效应大小对结果变量的影响。我们将使用效果大小来确定将来对干预措施进行更确定性测试所需的样本量。我们的目标人群，与16-20岁男性发生性关系的年轻男性是美国艾滋病毒/艾滋病收购的最高风险群体之一，但在干预文献中的代表性不足。 YMSM具有正确的工具，可以更好地做出减少艾滋病毒传播的决策。与R34指南一致，以支持干预开发和试点测试的早期阶段，最终产品将构成YMSM全面干预试验的基础。这项研究是一项整体研究计划的一部分，旨在了解和防止高风险青年的艾滋病毒感染。