Intervention Development: Reducing HIV Risk in Vulnerable Youth

干预措施的制定：降低弱势青少年的艾滋病毒风险

• 批准号: 7627263
• 负责人: Robert Garofalo
• 金额: $ 21.63万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-13 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627263
• 关键词: 20 year old; AIDS prevention; AIDS/HIV problem; Adolescence; Adolescent; Adult; African American; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Attitude; Behavior Therapy; Behavioral; Belief; Centers for Disease Control and Prevention (U.S.); Communities; Consent; Control Groups; Data; Data Analyses; Decision Making; Development; Discrimination; Drug usage; Educational Curriculum; Equilibrium; Esthesia; Feedback; Funding; Future; Goals; Guidelines; HIV; HIV Infections; Health; Homelessness; Human immunodeficiency virus test; Internet; Intervention; Intervention Studies; Intervention Trial; Knowledge; Latino; Life; Literature; Loneliness; Mental disorders; Mentally Ill Persons; Methods; Minority; Modeling; Outcome; Participant; Partner Communications; Personal Attribute; Pharmaceutical Preparations; Phase; Population; Population Study; Preparation; Prevention program; Primary Prevention; Procedures; Prophylactic treatment; Randomized Controlled Trials; Recruitment Activity; Research Design; Risk; Risk Behaviors; Risk-Taking; Sample Size; Sampling; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Site; Specific qualifier value; Staging; Stress; Substance abuse problem; Suggestion; Target Populations; Teenagers; Testing; Well in self; Work; Youth; base; cohort; condoms; depression; design; emotion regulation; empowered; experience; follow up assessment; follow-up; high risk; high risk sexual behavior; informant; information gathering; inner city; innovation; intervention effect; meetings; men who have sex with men; peer; post intervention; pressure; prevent; programs; psychosocial; racial and ethnic; runaway youth; self esteem; sex; sexual relationship; skills; social; social cognitive theory; substance use prevention; therapy development; tool; treatment effect; young adult

DESCRIPTION (provided by applicant): This exploratory/developmental application (R34) requests funds to design and pilot an HIV and substance use prevention program for 16-20 year-old ethnically-diverse, young men who have sex with men (YMSM). We will combine and adapt three innovative HIV and substance use prevention programs originally developed for adult MSM (Project MIX), runaway youth (Street Smart), and mentally ill adolescents (Project BALANCE). Project MIX is a federally-funded behavioral intervention for MSM who use drugs/alcohol. Street Smart is in the CDC compendium of empirically supported HIV prevention programs. Project BALANCE is an ongoing HIV prevention program for teens with psychiatric disorders. In stage 1, we will work with our advisory board and gather information from key young adult HIV+ MSM informants (N=21) to develop a uniquely tailored manualized intervention for YMSM drawing on Project MIX, Street Smart, and Project BALANCE. In stage 2, we will pilot test the intervention with cohort 1 -- a community-based sample of 20 ethnically-diverse YMSM (2 groups of 10 YMSM). We will examine the intervention's feasibility, acceptability and tolerability, and we will evaluate our tracking and retention strategies. We will refine the curriculum and study procedures based on participant feedback and advisory board input. In stage 3, we will test the revised intervention in a pilot randomized controlled trial (RCT) in a sample of 100 YMSM (cohort 2) - 50 YMSM in the experimental group and 50 YMSM in a control group. Cohort 1 will complete baseline and 3-month follow-up assessments to evaluate tracking and retention strategies. Cohort 2 will complete baseline, 3-, and 6-month follow-up to evaluate preliminary treatment effects. The intervention will be informed by social learning theory and a social- personal framework previously applied to the sexual and drug use behavior of at-risk youth. The intervention will target key determinants of risk taking among our specific population of YMSM, including: psychological well- being and emotion regulation, personal attributes, peer and partner relationships, sexual context variables, and sexual minority stress. Data analyses will (a) evaluate change in adolescent risky sexual behavior and substance abuse as a function of program participation, and (b) determine the pretest-posttest effect size of program impact on the outcome variables. We will use the effect size to determine the sample size needed for a more definitive test of the intervention in the future. Our target population, young men who have sex with men age 16-20, is one of the highest U.S. risk groups for HIV/AIDS acquisition, yet one that is woefully under-represented in the intervention literature. Empowered with the right tools, YMSM will be better equipped to make decisions that reduce the spread of HIV. Consistent with R34 guidelines to support the early phase of intervention development and pilot testing, the final product will form the basis for a full-scale intervention trial for YMSM. This study is part of an overall program of research designed to understand and prevent HIV infection among high-risk youth.

描述（由申请人提供）：本探索性/发展性申请（R34）要求提供资金，为16-20岁的种族多样性青年男性（YMSM）设计和试点艾滋病毒和药物使用预防方案。我们将联合收割机结合和调整三个创新的艾滋病毒和药物使用预防计划，最初是为成年男男性接触者（项目MIX），离家出走的青年（街头智能），和精神病青少年（项目平衡）。MIX项目是联邦政府资助的针对吸毒/酗酒的MSM的行为干预。Street Smart是CDC经验支持的艾滋病预防计划纲要中的一员。项目平衡是一个正在进行的艾滋病毒预防计划，为青少年与精神疾病。在第一阶段，我们将与我们的顾问委员会合作，并从主要的年轻成人艾滋病毒+男男性接触者（N=21）收集信息，以制定一个独特的定制手动干预YMSM借鉴项目MIX，街头智能，和项目平衡。在第二阶段，我们将对队列1进行干预试验-以社区为基础的20名不同种族的YMSM样本（2组，每组10名YMSM）。我们将检查干预的可行性，可接受性和耐受性，我们将评估我们的跟踪和保留策略。我们将根据参与者的反馈和咨询委员会的意见完善课程和学习程序。在第3阶段，我们将在一项试点随机对照试验（RCT）中测试修订后的干预措施，样本为100名YMSM（队列2）--实验组50名YMSM，对照组50名YMSM。队列1将完成基线和3个月随访评估，以评价跟踪和保留策略。队列2将完成基线、3个月和6个月随访，以评价初步治疗效果。干预将通过社会学习理论和社会-个人框架提供信息，该框架先前适用于高危青年的性和药物使用行为。干预将针对我们特定的YMSM人群中风险承担的关键决定因素，包括：心理健康和情绪调节，个人属性，同伴和伴侣关系，性背景变量和性少数压力。数据分析将（a）评估青少年危险性行为和药物滥用的变化作为项目参与的函数，（B）确定项目对结果变量影响的前后测效应大小。我们将使用效应量来确定未来更明确的干预测试所需的样本量。我们的目标人群是16-20岁的年轻男性，他们是美国感染艾滋病毒/艾滋病的最高风险群体之一，但在干预文献中却严重不足。有了正确的工具，YMSM将能够更好地做出减少艾滋病毒传播的决定。与R34指导方针一致，以支持干预开发和试点测试的早期阶段，最终产品将构成YMSM全面干预试验的基础。这项研究是一项旨在了解和预防高危青年艾滋病毒感染的整体研究计划的一部分。