"Strength training, Self-efficacy, and Function in Blacks with Prostate Cancer."

描述（由申请人提供）：非洲裔美国人（AA）男性的前列腺癌（PCa）发病率高于世界上任何其他种族或族裔群体，但在运动干预研究中代表性不足。雄激素剥夺疗法（ADT）是前列腺癌最常用的激素治疗。虽然这种治疗已被证明可以减缓现有肿瘤的生长，但睾酮的相关抑制导致肌肉萎缩，力量丧失，疲劳，骨质流失，脂肪沉积增加和功能下降，导致生活质量恶化。力量训练（ST）现在被认为是改善肌肉大小和力量并逆转与这些变化相关的功能下降的首选干预措施。出于这个原因，ST似乎是一种理想的干预措施，可以对抗常用于治疗PCa的ADT的不良后果。我们提出了两项平行研究来探讨ST作为干预措施改善接受ADT的AA PCa患者生活质量的有效性。这些研究将探讨ST作为改善接受ADT的AA PCa患者生活质量的干预措施的有效性。研究1将包括10周的单腿ST，其中未训练的腿将作为内部对照。这项研究将包括30名年龄在50岁至74岁之间的患有PCa的AA男性，他们将在ST干预前后接受腿部肌肉质量、力量、疲劳、力量和肌间脂肪横截面积的评估。研究2将包括所有主要肌肉群的12周全身ST。本研究将包括45名额外的志愿者，他们将在ST计划前后接受全身组成（脂肪、肌肉和骨密度）、肌肉力量、对PCa重要的血液蛋白、疲劳感知、日常生活活动和生活质量测量的评估。此外，还将检验两项研究对志愿者将继续参与ST（自我效能）信念的影响。因此，这两项研究将使我们能够提供关于ST改善接受ADT的AA PCa患者功能和生活质量的疗效以及患者继续参与ST计划的自我效能的重要和新颖信息。具体目标：具体目的是测量高质量ST干预计划对患有ADT的AA PCa患者的肌肉大小、肌肉功能、肌肉和脂肪组成、肌肉疲劳、疲劳感知、与PCa相关的血蛋白、生活质量、继续ST的意愿和进行日常生活活动（ADL）的能力的影响。将通过两项互补但独立的平行研究实现拟议目标。我们的总体假设是ST是抵消或逆转PCa患者ADT治疗的许多非预期不良后果的理想干预措施。我们的具体假设是，ST将导致身体成分，肌肉功能，功能能力和生活质量指标的改善，并且那些在这些措施中取得最大改善的人往往具有最高的自我效能得分。

DESCRIPTION (provided by applicant): African American (AA) men have a higher incidence of prostate cancer (PCa) than any other racial or ethnic group throughout the world, yet are underrepresented in exercise intervention studies. Androgen deprivation therapy (ADT) is the most commonly used hormone treatment for prostate cancer. Although this treatment has been shown to slow the growth of existing tumors, the associated suppression of testosterone leads to muscle atrophy, loss of strength, fatigue, bone loss, increased fat deposition, and functional declines that lead to a deterioration in quality of life. Strength training (ST) is now considered the intervention of choice to improve muscle size and strength and reverse the functional declines associated with these changes. For this reason, it would seem logical that ST would be an ideal intervention against the adverse consequences of ADT commonly used to treat PCa. We propose two parallel studies to address the effectiveness of ST as an intervention for improving quality of life in AA PCa patients on ADT. These studies will address the effectiveness of ST as an intervention for improving quality of life in AA PCa patients on ADT. Study 1 will consist of 10 weeks of single leg ST in which the untrained leg will serve as an internal control. This study will consist of 30 AA men with PCa between the ages of 50 and 74 who will undergo assessments of leg muscle mass, strength, fatigue, power and cross-sectional area of intermuscular fat before and after the ST intervention. Study 2 will consist of 12 weeks of whole-body ST of all major muscle groups. This study will consist of 45 additional volunteers who will undergo assessments of total body composition (fat, muscle and bone density), muscle strength, blood proteins important to PCa, fatigue perception, activities of daily living, and quality of life measures before and after the ST program. In addition, the effects of both studies on belief that volunteers will continue to participate in ST (self-efficacy) will be tested. Thus, these two studies will allow us to provide important and novel information about the efficacy of ST on improving function and quality of life in AA PCa patients on ADT, as well as the self-efficacy of patients to continue participation in a ST program. Specific Aims: The specific aims are to measure the impact of a high-quality ST intervention program on muscle size, muscle function, muscle and fat composition, muscle fatigue, fatigue perception, blood proteins associated with PCa, quality of life, willingness to continue to ST and ability to perform activities of daily living (ADL) in AA PCa patients with ADT. The proposed aim will be achieved using two complementary, but separate studies performed in parallel. Our global hypothesis is that ST is an ideal intervention for counteracting or reversing many of the unintended adverse consequences of ADT therapy in PCa patients. Our specific hypothesis is that ST will result in improvements in body composition, muscle function, functional abilities, and quality of life indicators, and that those who make the most improvements in these measures will tend to have the highest self-efficacy scores.7.