"Strength training, Self-efficacy, and Function in Blacks with Prostate Cancer."

描述(由申请人提供)：非裔美国人(AA)男性前列腺癌(PCA)的发病率高于世界上任何其他种族或民族，但在运动干预研究中代表性不足。雄激素剥夺疗法(ADT)是前列腺癌最常用的激素治疗方法。尽管这种治疗方法被证明可以减缓现有肿瘤的生长，但与此相关的睾丸素抑制会导致肌肉萎缩、力量丧失、疲劳、骨质丢失、脂肪沉积增加，以及导致生活质量下降的功能下降。力量训练(ST)现在被认为是改善肌肉大小和力量并扭转与这些变化相关的功能衰退的首选干预措施。因此，对于通常用于治疗前列腺癌的ADT的不良后果，ST似乎是一种理想的干预措施。我们提出了两项平行研究，以探讨ST作为改善服用ADT的AA PCA患者生活质量的干预措施的有效性。这些研究将探讨ST作为改善接受ADT治疗的AA PCA患者生活质量的干预措施的有效性。研究1将包括10周的单腿ST，其中未训练的腿将作为内部对照。这项研究将包括30名年龄在50岁到74岁之间患有前列腺癌的AA男性，他们将在ST干预前后接受腿部肌肉质量、力量、疲劳、功率和肌间脂肪横截面积的评估。研究2将包括12周的所有主要肌肉组的全身ST。这项研究将由另外45名志愿者组成，他们将在ST计划前后接受全身组成(脂肪、肌肉和骨密度)、肌肉力量、对PCA重要的血液蛋白质、疲劳感觉、日常生活能力和生活质量测量的评估。此外，这两项研究对志愿者将继续参与ST(自我效能感)的信念的影响将被测试。因此，这两项研究将使我们能够提供重要的和新的信息，关于ST在改善服用ADT的AA PCA患者的功能和生活质量方面的有效性，以及患者继续参与ST计划的自我效能。具体目标：具体目的是衡量高质量ST干预计划对AA PCA伴ADT患者的肌肉大小、肌肉功能、肌肉和脂肪组成、肌肉疲劳、疲劳感觉、与PCA相关的血液蛋白、生活质量、继续ST的意愿和执行日常生活活动(ADL)能力的影响。拟议的目标将通过平行进行的两项互补但独立的研究来实现。我们的全球假设是，ST是对抗或逆转前列腺癌患者ADT治疗的许多意外不良后果的理想干预措施。我们的具体假设是，ST将导致身体成分、肌肉功能、功能能力和生活质量指标的改善，那些在这些指标上改善最多的人往往拥有最高的自我效能得分。

DESCRIPTION (provided by applicant): African American (AA) men have a higher incidence of prostate cancer (PCa) than any other racial or ethnic group throughout the world, yet are underrepresented in exercise intervention studies. Androgen deprivation therapy (ADT) is the most commonly used hormone treatment for prostate cancer. Although this treatment has been shown to slow the growth of existing tumors, the associated suppression of testosterone leads to muscle atrophy, loss of strength, fatigue, bone loss, increased fat deposition, and functional declines that lead to a deterioration in quality of life. Strength training (ST) is now considered the intervention of choice to improve muscle size and strength and reverse the functional declines associated with these changes. For this reason, it would seem logical that ST would be an ideal intervention against the adverse consequences of ADT commonly used to treat PCa. We propose two parallel studies to address the effectiveness of ST as an intervention for improving quality of life in AA PCa patients on ADT. These studies will address the effectiveness of ST as an intervention for improving quality of life in AA PCa patients on ADT. Study 1 will consist of 10 weeks of single leg ST in which the untrained leg will serve as an internal control. This study will consist of 30 AA men with PCa between the ages of 50 and 74 who will undergo assessments of leg muscle mass, strength, fatigue, power and cross-sectional area of intermuscular fat before and after the ST intervention. Study 2 will consist of 12 weeks of whole-body ST of all major muscle groups. This study will consist of 45 additional volunteers who will undergo assessments of total body composition (fat, muscle and bone density), muscle strength, blood proteins important to PCa, fatigue perception, activities of daily living, and quality of life measures before and after the ST program. In addition, the effects of both studies on belief that volunteers will continue to participate in ST (self-efficacy) will be tested. Thus, these two studies will allow us to provide important and novel information about the efficacy of ST on improving function and quality of life in AA PCa patients on ADT, as well as the self-efficacy of patients to continue participation in a ST program. Specific Aims: The specific aims are to measure the impact of a high-quality ST intervention program on muscle size, muscle function, muscle and fat composition, muscle fatigue, fatigue perception, blood proteins associated with PCa, quality of life, willingness to continue to ST and ability to perform activities of daily living (ADL) in AA PCa patients with ADT. The proposed aim will be achieved using two complementary, but separate studies performed in parallel. Our global hypothesis is that ST is an ideal intervention for counteracting or reversing many of the unintended adverse consequences of ADT therapy in PCa patients. Our specific hypothesis is that ST will result in improvements in body composition, muscle function, functional abilities, and quality of life indicators, and that those who make the most improvements in these measures will tend to have the highest self-efficacy scores.7.