GENE EFFECTS ON STRENGTH RESPONSES TO AGE AND EXERCISE

基因对年龄和运动力量反应的影响

• 批准号: 6509921
• 负责人: BERNARD F HURLEY
• 金额: $ 36.54万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509921
• 关键词: aging; alleles; clinical research; cytokine receptors; exercise; genetics; human subject; insulinlike growth factor; interleukin 15; longitudinal human study; neurotrophic factors; sarcopenia; tumor necrosis factor alpha

DESCRIPTION: (provided by applicant) Losses of muscular strength and muscle mass with age (sarcopenia) and gains with strength training in the elderly are well documented, but these responses vary substantially among individuals. This large interindividual variability and the fact that twin studies show that a major portion of the variance in strength and muscle mass can be accounted for by heredity, suggest that genetic factors may explain a large portion of interindividual differences in strength and muscle mass responses to aging and strength training. In a recent pilot study, we observed that a common polymorphism at the ciliary neurotrophic factor (CNTF) gene locus was a significant predictor of age-associated strength levels and that a common polymorphism at the insulin-like growth factor II (IGF-Il) gene locus was significantly associated with strength increases in response to strength training. Moreover, polymorphisms at the IGF-l, tumor necrosis factor (TNF) alpha, and IL-15 receptor gene loci showed a pattern for being associated with strength and/or muscle mass response to strength training. Therefore, this study will test our primary hypotheses in both cross-sectional and longitudinal studies, that the polymorphism at the CNTF gene locus will affect strength levels in older persons and losses in strength with age, and that the polymorphism at the IGF-II gene locus will affect strength and muscle mass responses to strength training in elderly women and men. We will also test exploratory hypotheses that polymorphisms at the IGF-l, and TNF alpha gene loci will affect losses in strength and muscle mass with age and that a polymorphism at the TNF alpha and IL-15 receptor gene Loci will affect strength or muscle mass gains with strength training in elderly women and men. Findings consistent with our hypotheses could result in identifying those most likely to need interventions for sarcopenia and the optimal manner of stratifying strength training to those benefiting the most. Conversely, identifying persons who improve their strength and muscle mass the least with strength training would allow them to focus on interventions that might be more efficacious for them.

描述：（由申请人提供）肌肉力量和肌肉丧失 老年人的体重随年龄增长（肌肉减少症）和力量训练的增加是 有据可查，但这些反应因人而异。这 巨大的个体差异以及双胞胎研究表明 力量和肌肉质量差异的主要部分可以被解释 通过遗传，表明遗传因素可以解释很大一部分 力量和肌肉质量对衰老的反应存在个体差异 力量训练。在最近的一项试点研究中，我们观察到一个常见的 睫状神经营养因子（CNTF）基因位点的多态性 与年龄相关的力量水平的重要预测因子，并且一个常见的 胰岛素样生长因子 II (IGF-II) 基因位点的多态性 与响应力量的力量增加显着相关 训练。此外，IGF-1、肿瘤坏死因子 (TNF) 的多态性 α和IL-15受体基因位点显示出与相关的模式 力量和/或肌肉质量对力量训练的反应。因此，这 研究将从横截面和纵向两个方面检验我们的主要假设 研究表明CNTF基因位点的多态性会影响强度 老年人的水平以及随着年龄的增长而丧失的力量，并且 IGF-II 基因位点的多态性会影响力量和肌肉质量 老年女性和男性对力量训练的反应。我们也会测试 IGF-l 和 TNF α 基因位点多态性的探索性假设 会影响随着年龄的增长力量和肌肉质量的损失，并且多态性 TNFα和IL-15受体基因位点会影响力量或肌肉 老年女性和男性通过力量训练获得大量收益。研究结果一致 根据我们的假设可能会确定那些最有可能需要的人 肌肉减少症的干预措施和分层力量的最佳方式 为受益最多的人提供培训。相反，识别那些 通过力量训练至少可以提高他们的力量和肌肉质量 让他们专注于可能对他们更有效的干预措施。