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GENOTYPE, AGE, MUSCULAR STRENGTH AND MUSCLE MASS

基因型、年龄、肌肉力量和肌肉质量

基本信息

批准号：
6124015
负责人：
BERNARD F HURLEY
金额：
$ 9.83万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-12-02 至 2002-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (Adapted from the Applicant's Abstract): Losses of muscular strength and muscle mass with age (sarcopenia) and gains with strength training are well documented, but these responses vary substantially among individuals. Environmental factors, such as differences in exercise levels, do not explain the large inter-individual differences in strength and muscle mass observed with aging or strength training. This suggests that genetic factors may account for at least a portion of these inter-individual differences. Genes that appear to be good candidates for aging- and strength training-induced changes in muscle mass include growth hormone (GH), insulin-like growth factor-I (IGF-I), IGF-I receptor, IGF binding protein (IGFBP)-2 and 4, myostatin, and components of the dystrophin-glycoprotein complex. However, specific genes have not been identified. Thus, it is hypothesized that the effects of age and strength training on muscular strength and muscle mass are affected by polymorphic variations at these critical skeletal muscle-related gene loci. To test this hypothesis genotypes will be determined cross-sectionally in 800 subjects across the adult life span from the Baltimore Longitudinal Study of Aging (BLSA). All of these subjects will have already been tested for strength and most (~600 subjects) will have been tested for muscle mass by the time this study begins. Genotypes also will be determined in 100 subjects who have completed a standardized strength training program in previous longitudinal studies in this laboratory. In the BLSA study, strength and muscle mass will be analyzed by general linear model procedures to fit the effects of genotype, gender, and age as regression variables and the interactions of these variables. In the strength training study, linear mixed model procedures will be used with the fixed portion containing the effects of genotype, strength training, and their interactions. The potential significance of this study is that it may identify subjects prone to early onset of sarcopenia and provide information about who might be most responsive to strength training interventions designed to reverse the effects of sarcopenia.

描述（改编自申请人的摘要）：肌肉丧失力量和肌肉质量随着年龄的增长（肌肉减少症）以及随着力量的增加而增加培训有详细记录，但这些反应差异很大个人之间。环境因素，例如差异运动水平，并不能解释个体间的巨大差异通过衰老或力量训练观察到的力量和肌肉质量。这表明遗传因素可能至少占一部分这些个体间的差异。看似良好的基因衰老和力量训练引起的肌肉变化的候选者质量包括生长激素（GH）、胰岛素样生长因子-I（IGF-I）、 IGF-I 受体、IGF 结合蛋白 (IGFBP)-2 和 4、肌生长抑制素和肌营养不良蛋白-糖蛋白复合物的组成部分。不过，具体基因尚未确定。因此，假设年龄和力量训练对肌肉力量和肌肉的影响质量受到这些关键骨骼的多态性变异的影响肌肉相关基因位点。为了检验这个假设，基因型将是在 800 名受试者的整个成年生命周期中进行横断面测定来自巴尔的摩老龄化纵向研究（BLSA）。所有这些受试者已经接受过力量测试，并且大多数（~600 受试者）在本研究时已接受肌肉质量测试开始。还将确定 100 名受试者的基因型之前完成了标准化力量训练计划该实验室的纵向研究。在 BLSA 研究中，强度和肌肉质量将通过一般线性模型程序进行分析以拟合基因型、性别和年龄作为回归变量的影响这些变量的相互作用。在力量训练研究中，线性混合模型程序将与包含的固定部分一起使用基因型、力量训练及其相互作用的影响。这这项研究的潜在意义在于它可以确定受试者容易出现早发性肌肉减少症，并提供有关谁的信息可能对力量训练干预措施反应最灵敏，旨在逆转肌肉减少症的影响。