COBRE: UVT: BIOMEDICAL ENGINEERING CORE: PULMONARY VASCULAR & RESPIRATORY SYST

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物医学工程是一个新兴的交叉学科领域，涉及将物理、化学、数学和工程科学的方法应用于生理学、医学、行为学或健康。它的特点是它为生物医学问题带来了一系列科学和工程工具。VLC-Cobre范围内的所有研究项目都有仪器、计算和定量方法的要求。因此，生物医学工程(BME)核心将为VLC-Cobre研究计划发挥重要和统一的作用。为了满足具体项目和总体计划的需要，需要实现三个具体目标。首先是与VLC-Cobre的研究人员合作，为研究开发新的、最先进的工程工具。这一复杂的目标包括四个组成部分：1)设计和建造仪器硬件，2)开发和实施数字信号和图像处理软件，3)组装用于定量评估小动物呼吸系统动力学的工具，以及4)开发用于模拟肺血管和呼吸系统的数值和分析工具。实现第一个目标将使VLC-Cobre研究人员能够在严格控制下进行科学复杂的实验，用复杂的时间和频率信息解释结果，测量体内的呼吸力学，并开发生理和病理过程的预测模型。BME核心的第二个具体目标是教育VLC-Cobre调查人员正确使用仪器硬件、定量数据分析技术和数学建模。计划提供理论和实践相结合的教程。清楚了解其设备的优点和局限性的调查人员将更有效地使用它。此外，BME核心将鼓励和促进工程师和生物医学科学家之间的合作研究，以改善UVM的生物医学工程环境。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biomedical engineering is a burgeoning interdisciplinary field that involves adapting methods from the physical, chemical, mathematical and engineering sciences for application to physiology, medicine, behavior or health. It is characterized by the range of scientific and engineering tools it brings to bear on biomedical problems. All research projects within the VLC-COBRE have requirements for instrumentation, computation and quantitative methods. Accordingly, the Biomedical Engineering (BME) Core will serve a vital and unifying role for the VLC-COBRE research program. Three specific aims are required to meet the needs of specific projects and the overall program. The first is to work with VLC-COBRE investigators to develop novel, state-of-the-art engineering tools for research. This complex aim has four components: 1) design and construction of instrumentation hardware, 2) development and implementation of digital signal and image processing software, 3) assembly of tools for quantitatively assessing respiratory system dynamics in small animals, and 4) development of numerical and analytical tools for modeling the pulmonary vascular and respiratory systems. Achieving this first aim will allow VLC-COBRE investigators to perform scientifically sophisticated experiments under rigorous control, interpret results with complex time and frequency information, measure respiratory mechanics in vivo and develop predictive models of physiological and pathological processes. The second specific aim of the BME Core is to educate VLC-COBRE investigators in the appropriate use of instrumentation hardware, quantitative data analysis techniques and mathematical modeling. A combination of theoretical and practical tutorials is planned. Investigators who clearly understand the advantages and limitations of their equipment will use it more efficiently and effectively. In addition, the BME Core will encourage and facilitate collaborative research between engineers and biomedical scientists to enhance the Biomedical Engineering environment at UVM.