COBRE: UVT: BIOMEDICAL ENGINEERING CORE: PULMONARY VASCULAR & RESPIRATORY SYST

COBRE：UVT：生物医学工程核心：肺血管

• 批准号: 7959619
• 负责人: Jason HT Bates
• 金额: $ 29.96万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959619
• 关键词: Animals; Arts; Behavior; Biology; Biomedical Engineering; Blood Vessels; Centers of Research Excellence; Chemicals; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Data Analyses; Development; Engineering; Environment; Equipment; Frequencies; Funding; Grant; Health; Institution; Lung; Measures; Medicine; Methods; Modeling; Pathologic Processes; Physiological; Physiology; Research; Research Personnel; Research Project Grants; Resources; Respiratory Mechanics; Respiratory System; Role; Science; Signal Transduction; Source; Techniques; Time; Translational Research; United States National Institutes of Health; Ursidae Family; Work; analytical tool; biomedical scientist; design and construction; digital; image processing; in vivo; instrumentation; mathematical model; meetings; novel; predictive modeling; programs; research study; respiratory; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biomedical engineering is a burgeoning interdisciplinary field that involves adapting methods from the physical, chemical, mathematical and engineering sciences for application to physiology, medicine, behavior or health. It is characterized by the range of scientific and engineering tools it brings to bear on biomedical problems. All research projects within the VLC-COBRE have requirements for instrumentation, computation and quantitative methods. Accordingly, the Biomedical Engineering (BME) Core will serve a vital and unifying role for the VLC-COBRE research program. Three specific aims are required to meet the needs of specific projects and the overall program. The first is to work with VLC-COBRE investigators to develop novel, state-of-the-art engineering tools for research. This complex aim has four components: 1) design and construction of instrumentation hardware, 2) development and implementation of digital signal and image processing software, 3) assembly of tools for quantitatively assessing respiratory system dynamics in small animals, and 4) development of numerical and analytical tools for modeling the pulmonary vascular and respiratory systems. Achieving this first aim will allow VLC-COBRE investigators to perform scientifically sophisticated experiments under rigorous control, interpret results with complex time and frequency information, measure respiratory mechanics in vivo and develop predictive models of physiological and pathological processes. The second specific aim of the BME Core is to educate VLC-COBRE investigators in the appropriate use of instrumentation hardware, quantitative data analysis techniques and mathematical modeling. A combination of theoretical and practical tutorials is planned. Investigators who clearly understand the advantages and limitations of their equipment will use it more efficiently and effectively. In addition, the BME Core will encourage and facilitate collaborative research between engineers and biomedical scientists to enhance the Biomedical Engineering environment at UVM.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 生物医学工程是一个新兴的跨学科领域，涉及将物理、化学、数学和工程科学的方法应用于生理学、医学、行为或健康。它的特点是利用一系列科学和工程工具来解决生物医学问题。 VLC-COBRE 内的所有研究项目都对仪器、计算和定量方法有要求。因此，生物医学工程 (BME) 核心将为 VLC-COBRE 研究计划发挥至关重要的统一作用。需要三个具体目标来满足具体项目和总体计划的需要。第一个是与 VLC-COBRE 研究人员合作开发新颖、最先进的研究工程工具。这个复杂的目标有四个组成部分：1）仪器硬件的设计和构建，2）数字信号和图像处理软件的开发和实施，3）用于定量评估小动物呼吸系统动力学的工具组装，以及4）开发用于模拟肺血管和呼吸系统的数值和分析工具。实现第一个目标将使 VLC-COBRE 研究人员能够在严格的控制下进行科学复杂的实验，用复杂的时间和频率信息解释结果，测量体内呼吸力学并开发生理和病理过程的预测模型。 BME 核心的第二个具体目标是教育 VLC-COBRE 研究人员正确使用仪器硬件、定量数据分析技术和数学建模。计划将理论和实践教程相结合。清楚了解其设备的优点和局限性的研究人员将更有效地使用它。此外，BME 核心将鼓励和促进工程师和生物医学科学家之间的合作研究，以增强 UVM 的生物医学工程环境。