DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们设计并构建了一种新型的质谱仪，用于分析蛋白质上的磷酸化位点。该仪器被设计成比目前市售的仪器多三个数量级。我们已经测试了原型，发现它按照设计和我们的模拟工作。我们已经为这种新设计申请了专利

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have designed and constructed a novel mass spectrometer for profiling phosphorylation sites on proteins. The instrument is designed to be up to three orders of magnitude more semsitive than current commercially available instrumentation. We have tested the prototype and found that it works as per its design and our simulations. We have applied for a patent covering the new design