DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们设计并构建了一种新型质谱仪，用于分析蛋白质磷酸化位点。该仪器的灵敏度比目前市售的仪器高3个数量级。我们已经测试了原型机，发现它按照设计和我们的模拟工作。我们已经申请了这项新设计的专利

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have designed and constructed a novel mass spectrometer for profiling phosphorylation sites on proteins. The instrument is designed to be up to three orders of magnitude more semsitive than current commercially available instrumentation. We have tested the prototype and found that it works as per its design and our simulations. We have applied for a patent covering the new design