DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们设计并建造了一种新型的质谱仪，用于分析蛋白质上的磷酸化位点。该仪器的设计比目前商业上可用的仪器高出三个数量级。我们已经测试了原型，发现它按照设计和我们的模拟工作。基于我们新颖的设计，已经申请了一项美国专利。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have designed and constructed a novel mass spectrometer for profiling phosphorylation sites on proteins. The instrument is designed to be up to three orders of magnitude more semsitive than current commercially available instrumentation. We have tested the prototype and found that it works as per its design and our simulations. A US patent has been applied for based on our novel design.