NO: A nitric oxide synthase generated chemical effector of fungal pathogenesis

NO：一氧化氮合酶产生的真菌发病机制的化学效应子

• 批准号: BB/G00207X/1
• 负责人: Sarah Gurr
• 金额: $ 49.45万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FG00207X%2F1
• 关键词: NO; nitric; oxide; synthase; generated

The world relies heavily on a handful of food crops. Of these, rice forms the staple diet of half of the world's population. However, rice and 50 other known grasses, are vulnerable to attack by the rice blast fungus. Such attack can lead to very significant crop losses. This may have implications for UK cereal crops - if global climate change leads to a rise in ambient temperature, rice blast disease will infiltrate Europe. Currently, disease is moderately well controlled by fungicides or by the use of rice varieties bred to carry extra disease resistance genes. Both are problematic: fungicides are costly, antifungal activity can be lost and inbred disease resistance can be lost due to the emergence of new and aggressive races of the fungus. Whilst we have made great strides towards understanding fungal invasion, much remains to be discovered. Detailed knowledge of the processes underpinning fungal attack will allow us to identify weak links during the early stages of fungal attack. This will empower us with the knowledge to design more environmentally benign modes of crop protection. This project aims to look at signals the fungus uses to drive the formation of its infection structures. More specifically, it will look at the generation and consequence of chemical effectors of fungal disease.

世界严重依赖少数几种粮食作物。其中，大米是世界上一半人口的主食。然而，水稻和其他50种已知的草很容易受到稻瘟病菌的攻击。这样的袭击可能导致非常严重的农作物损失。这可能会对英国的谷类作物产生影响--如果全球气候变化导致环境温度上升，稻瘟病将渗透到欧洲。目前，通过杀菌剂或利用培育出携带额外抗病基因的水稻品种，可以较好地控制疾病。这两种方法都有问题：杀菌剂价格昂贵，可能会失去抗真菌活性，而且由于出现新的侵略性真菌小种，可能会失去近亲繁殖的抗病能力。虽然我们已经在了解真菌入侵方面取得了长足的进步，但仍有许多事情有待发现。对真菌侵袭过程的详细了解将使我们能够在真菌侵袭的早期阶段识别薄弱环节。这将使我们有能力设计更环保的作物保护模式。该项目旨在研究这种真菌用来驱动其感染结构形成的信号。更具体地说，它将着眼于真菌疾病化学效应物的产生和后果。

项目成果

Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection.

毛磷脂和相关皮肤植物的比较基因组分析揭示了参与感染的候选基因。

• DOI: 10.1128/mbio.00259-12
• 发表时间: 2012
• 期刊: mBio
• 影响因子: 6.4
• 作者: Martinez DA;Oliver BG;Gräser Y;Goldberg JM;Li W;Martinez-Rossi NM;Monod M;Shelest E;Barton RC;Birch E;Brakhage AA;Chen Z;Gurr SJ;Heiman D;Heitman J;Kosti I;Rossi A;Saif S;Samalova M;Saunders CW;Shea T;Summerbell RC;Xu J;Young S;Zeng Q;Birren BW;Cuomo CA;White TC
• 通讯作者: White TC

Validation of Reference Genes for Robust qRT-PCR Gene Expression Analysis in the Rice Blast Fungus Magnaporthe oryzae.

水稻疫霉菌 Magnaporthe oryzae 中用于稳健 qRT-PCR 基因表达分析的参考基因验证

• DOI: 10.1371/journal.pone.0160637
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Che Omar S;Bentley MA;Morieri G;Preston GM;Gurr SJ
• 通讯作者: Gurr SJ

The rise and rise of emerging infectious fungi challenges food security and ecosystem health

• DOI: 10.1016/j.fbr.2011.10.004
• 发表时间: 2011-12-01
• 期刊: Fungal Biology Reviews
• 影响因子: 6
• 作者: Gurr, Sarah;Samalova, Marketa;Fisher, Matthew
• 通讯作者: Fisher, Matthew

Atomic-scale structure of biogenic materials by total X-ray diffraction: a study of bacterial and fungal MnOx.

• DOI: 10.1021/nn800653a
• 发表时间: 2009-01
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: V. Petkov;Yang Ren;Ian Saratovsky;Pablo A. Pastén;Sarah J. Gurr;Michael A. Hayward;K. Poeppelmeier;Jean-François Gaillard

Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis.

• DOI: 10.1371/journal.ppat.1005703
• 发表时间: 2016-06
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Geoghegan IA;Gurr SJ
• 通讯作者: Gurr SJ