Signals and Sensors: Are particular Magnaporthe grisea cutinases pivotal in host perception priming signal relay and pathogenicity?

信号和传感器：特定的稻瘟病菌角质酶在宿主感知启动信号传递和致病性中至关重要吗？

• 批准号: BB/D009766/1
• 负责人: Sarah Gurr
• 金额: $ 27.3万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD009766%2F1
• 关键词: Signals; Sensors; particular; Magnaporthe; grisea

Fungi are the most important and destructive 'agents' of plant disease. Indeed, a serious and recurrent problem is caused by the rice blast fungus Magnaporthe grisea, which annually destroys sufficient rice to feed the population of GB, presupposing that our staple diet depended on this grain alone. Much is known about the biology of the fungal infection process and scientists recently reported its genome sequence. This fungus serves as an excellent model system for understanding the 'goings-on' between plant and pathogen. In this proposal we seek to understand whether the fungus 'talks' to the plant via a mechanism / series of cutinase enzymes which specifically degrade the plant cuticle and whether the cuticle breakdown products signal back to the fungus to make it form its leaf infection structures. Moreover, we know thatseveral of these cutinases exist in the rice blast fungus and we seek to understand whether one is involved in penetration of the host plant.

真菌是植物病害的最重要和最具破坏性的“代理人”。事实上，稻瘟病菌造成了一个严重和经常性的问题，它每年都会破坏足够养活GB人口的大米，假设我们的主食仅依赖于这种谷物。关于真菌感染过程的生物学知识很多，科学家最近报道了其基因组序列。这种真菌作为一个很好的模型系统，了解植物和病原体之间的“事情”。在这个建议中，我们试图了解真菌是否通过一种机制/一系列角质酶与植物“交谈”，这些角质酶特异性地降解植物角质层，以及角质层分解产物是否向真菌发出信号，使其形成叶片感染结构。此外，我们知道几种角质酶存在于稻瘟病菌中，我们试图了解其中一种角质酶是否参与侵入寄主植物。

项目成果

The fate of gene duplicates in the genomes of fungal pathogens.

真菌病原体基因组中基因重复的命运。

• DOI: 10.4161/cib.1.2.7144
• 发表时间: 2008
• 期刊: Communicative & integrative biology
• 作者: Skamnioti P

Gene microarray analysis using angular distribution decomposition.

使用角分布分解进行基因微阵列分析。

• DOI: 10.1089/cmb.2006.0098
• 发表时间: 2007
• 期刊: a journal of computational molecular cell biology
• 作者: Lees K

Host perception and signal transduction studies in wild-type Blumeria graminis f. sp. hordei and a quinoxyfen-resistant mutant implicate quinoxyfen in the inhibition of serine esterase activity.

野生型 Blumeria graminis f 的宿主感知和信号转导研究。

• DOI: 10.1002/ps.1538
• 发表时间: 2008
• 期刊: Pest management science
• 影响因子: 4.1
• 作者: Lee S

A novel role for catalase B in the maintenance of fungal cell-wall integrity during host invasion in the rice blast fungus Magnaporthe grisea.

• DOI: 10.1094/mpmi-20-5-0568
• 发表时间: 2007-04
• 期刊: Molecular plant-microbe interactions : MPMI
• 作者: Pari Skamnioti;Catherine Henderson;Ziguo Zhang;Zena Robinson;S. Gurr

Evolutionary history of the ancient cutinase family in five filamentous Ascomycetes reveals differential gene duplications and losses and in Magnaporthe grisea shows evidence of sub- and neo-functionalization.

• DOI: 10.1111/j.1469-8137.2008.02598.x
• 发表时间: 2008-11
• 期刊: The New phytologist
• 作者: Pari Skamnioti;R. F. Furlong;S. Gurr