CANCER GENETICS NETWORK

虽然癌症遗传学的进展很快，但关于遗传易感性和预防的关键问题仍然没有得到回答。为了响应癌症遗传学网络的RFA，我们建议：(1)招募大量以下人群加入CGN：(A)遗传性乳腺癌、卵巢癌和结肠癌家族，(B)新诊断的高危乳腺癌患者，以及(C)癌症低风险到中等风险的人；(2)利用我们现有的社区医院和初级保健诊所网络，增加华盛顿特区地区非裔美国人和拉丁美洲人的CGN登记人数；(3)向CGN贡献我们经过IRB批准的经过充分验证的知情同意、测试前教育和遗传咨询协议；(4)向CGN调查人员提供我们用于诊断基因分析的最先进实验室技术；(5)利用我们现有的癌症DNA/组织收集、处理和存储基础设施，为CGN的癌症遗传学基础研究做出贡献；(6)修改现有的癌症遗传学教材，以非洲裔美国人为目标，并开发西班牙语材料、同意书和咨询协议，供拉丁美洲人使用；(7)为广泛的医疗保健提供者提供遗传学教育和培训计划，包括护士和医科学生；以及(8)贡献我们的专业知识，开展癌症易感性基因测试的临床、心理社会和经济结果研究。

While advances in cancer genetics are occurring at rapid pace, critical questions about genetic susceptibility and prevention remain unanswered. In response to the RFA for the Cancer Genetics Network, we propose to: (1) Enroll substantial numbers of the following populations into the CGN: (a) hereditary breast, ovarian, and colon cancer families, (b) newly diagnosed high risk breast cancer patients, and (c) persons at low to moderate risk of cancer; (2) Utilize our existing networks of community-based hospitals and primary care clinics to increase CGN enrollment of African Americans and Latin Americans in the Washington, D.C. area; (3) Contribute our well-validated IRB-approved protocols for informed consent, pre-test education, and genetic counseling to the CGN; (4) Provide CGN investigators with access to our state-of-the-art laboratory technologies for diagnostic genetic analysis; (5) Utilize our existing infrastructure for cancer DNA/tissue collection, processing, and storage to contribute to basic cancer genetics research in the CGN; (6) Modify existing cancer genetics educational materials to target African Americans and develop Spanish language materials, consent forms and counseling protocols for use with Latin Americans; (7) Provide genetics education and training programs for a wide range of healthcare providers, including nurses and medical students; and (8) Contribute our expertise conducting research on the clinical, psychosocial, and economic outcomes of genetic testing for cancer susceptibility.