CANCER GENETICS NETWORK

描述：（申请人的描述）虽然癌症遗传学的进展 正在快速发生，关于遗传易感性的关键问题 和预防仍然没有答案。 针对癌症的RFA 遗传学网络，我们建议：（1）招收大量的 以下人群进入CGN：（a）遗传性乳腺癌，卵巢癌，和 结肠癌家族，（B）新诊断的高风险乳腺癌患者， 及（c）患癌风险低至中度的人士;（2）利用我们现有的 社区医院和初级保健诊所网络，以增加 CGN在华盛顿招收非洲裔美国人和拉丁美洲人， 特区（3）贡献我们经过充分验证的IRB批准的方案， 知情同意，预测试教育和遗传咨询的CGN;（4） 为CGN研究人员提供访问我们最先进的实验室的机会 基因诊断分析技术;（5）利用我们现有的 用于癌症DNA/组织收集、处理和存储的基础设施， 有助于CGN的基础癌症遗传学研究;（6）修改现有的 针对非裔美国人的癌症遗传学教育材料， 制定西班牙语材料、同意书和咨询协议 （7）提供遗传学教育和培训 为广泛的医疗保健提供者，包括护士和 医学生;（8）贡献我们的专业知识进行研究， 基因检测的临床，心理和经济结果， 癌症易感性

DESCRIPTION: (Applicant's Description) While advances in cancer genetics are occurring at rapid pace, critical questions about genetic susceptibility and prevention remain unanswered. In response to the RFA for the Cancer Genetics Network, we propose to: (1) Enroll substantial numbers of the following populations into the CGN: (a) hereditary breast, ovarian, and colon cancer families, (b) newly diagnosed high risk breast cancer patients, and (c) persons at low to moderate risk of cancer; (2) Utilize our existing networks of community-based hospitals and primary care clinics to increase CGN enrollment of African Americans and Latin Americans in the Washington, D.C. area; (3) Contribute our well-validated IRB-approved protocols for informed consent, pre-test education, and genetic counseling to the CGN; (4) Provide CGN investigators with access to our state-of-the-art laboratory technologies for diagnostic genetic analysis; (5) Utilize our existing infrastructure for cancer DNA/tissue collection, processing, and storage to contribute to basic cancer genetics research in the CGN; (6) Modify existing cancer genetics educational materials to target African Americans and develop Spanish language materials, consent forms and counseling protocols for use with Latin Americans; (7) Provide genetics education and training programs for a wide range of healthcare providers, including nurses and medical students; and (8) Contribute our expertise conducting research on the clinical, psychosocial, and economic outcomes of genetic testing for cancer susceptibility.