Asymmetric Oxidation using Immobilised Catalysts

使用固定化催化剂的不对称氧化

• 批准号: EP/C523067/1
• 负责人: Graham Hutchings
• 金额: $ 34.16万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FC523067%2F1
• 关键词: Asymmetric; Oxidation; using; Immobilised; Catalysts

We have recently discovered a new catalytic procedure for asymmetric epoxidation, applicable to unfunctionalized alkene substrates in solution. We would emphasise the extreme simplicity of the procedure described, the ease of preparation of a wide range of catalysts without need for chromatography, the absence of any sensitive materials or toxic heavy metals, the use of water as co-solvent, and the retention of double bond stereochemistry. The procedure requires no close monitoring, and provides remarkably clean reactions in an inexpensive, simple, and rapid process using minimal quantities of catalyst. Overall, the synthesis of a typical catalyst and the asymmetric oxidation together takes no longer than 6 hours. Further development by modification of catalyst structure and extension to functionalized alkene substrates is now desirable. This proposal alms to improve an these initial findings and we seek to prepare improved activity catalysts and to improve the scope aid generally of the approach. We plan to develop immobilised catalysts in which the catalysts are retained on the surface of inorganic supports by electrostatic Interaction. We plan to develop a new stable, fully reusable catalyst for important oxidation reactions.

我们最近发现了一种新的催化不对称环氧化的方法，适用于溶液中的非官能化烯烃底物。我们要强调的是，所描述的过程极其简单，无需色谱就可以轻松制备各种催化剂，不含任何敏感材料或有毒重金属，使用水作为助溶剂，并保留双键立体化学。该过程不需要密切监测，并且在使用少量催化剂的廉价、简单和快速的过程中提供了非常干净的反应。总的来说，一个典型催化剂的合成和不对称氧化在一起不超过6小时。现在希望通过改性催化剂结构和扩展到功能化烯烃底物来进一步发展。该建议有助于改进这些初步发现，我们寻求制备改进的活性催化剂，并改善该方法的总体范围。我们计划开发固定化催化剂，其中催化剂通过静电相互作用保留在无机载体表面。我们计划开发一种新的稳定的、完全可重复使用的催化剂，用于重要的氧化反应。