Asymmetric Oxidation using Immobilised Catalysts

我们最近发现了一种新的催化不对称环氧化反应的方法，适用于溶液中非官能化的烯烃底物。我们要强调的是所描述的过程极其简单，各种催化剂的制备都非常容易，不需要层析，没有任何敏感材料或有毒重金属，使用水作为共溶剂，以及保留双键立体化学。该方法不需要密切监测，反应非常清洁，反应成本低、简单、快速，只需最少的催化剂。总体而言，合成典型的催化剂和不对称氧化一起花费的时间不超过6小时。通过修改催化剂结构和扩展到功能化的烯烃底物来进一步开发现在是可取的。这一建议有助于改善这些初步发现，我们寻求制备改进的活性催化剂，并改善该方法的总体范围。我们计划开发固定化催化剂，通过静电相互作用将催化剂保留在无机载体的表面。我们计划开发一种新的稳定、完全可重复使用的催化剂，用于重要的氧化反应。

We have recently discovered a new catalytic procedure for asymmetric epoxidation, applicable to unfunctionalized alkene substrates in solution. We would emphasise the extreme simplicity of the procedure described, the ease of preparation of a wide range of catalysts without need for chromatography, the absence of any sensitive materials or toxic heavy metals, the use of water as co-solvent, and the retention of double bond stereochemistry. The procedure requires no close monitoring, and provides remarkably clean reactions in an inexpensive, simple, and rapid process using minimal quantities of catalyst. Overall, the synthesis of a typical catalyst and the asymmetric oxidation together takes no longer than 6 hours. Further development by modification of catalyst structure and extension to functionalized alkene substrates is now desirable. This proposal alms to improve an these initial findings and we seek to prepare improved activity catalysts and to improve the scope aid generally of the approach. We plan to develop immobilised catalysts in which the catalysts are retained on the surface of inorganic supports by electrostatic Interaction. We plan to develop a new stable, fully reusable catalyst for important oxidation reactions.