Asymmetric Oxidation using Immobilised Catalysts

我们最近发现了一种新的不对称环氧化催化方法，适用于非官能化烯烃底物在溶液中。我们将强调所描述的程序的极端简单性，易于制备各种催化剂而不需要色谱法，不存在任何敏感材料或有毒重金属，使用水作为共溶剂，以及保留双键立体化学。该方法不需要密切监测，并且以廉价、简单和快速的方法使用最少量的催化剂提供非常清洁的反应。总的来说，典型催化剂的合成和不对称氧化一起花费不超过6小时。现在需要通过改性催化剂结构和延伸到官能化烯烃底物的进一步开发。该建议有助于改进这些初步发现，并且我们寻求制备改进的活性催化剂，并改善该方法的范围。我们计划开发固定化催化剂，其中催化剂通过静电相互作用保留在无机载体的表面上。我们计划开发一种新的稳定的，完全可重复使用的催化剂，用于重要的氧化反应。

We have recently discovered a new catalytic procedure for asymmetric epoxidation, applicable to unfunctionalized alkene substrates in solution. We would emphasise the extreme simplicity of the procedure described, the ease of preparation of a wide range of catalysts without need for chromatography, the absence of any sensitive materials or toxic heavy metals, the use of water as co-solvent, and the retention of double bond stereochemistry. The procedure requires no close monitoring, and provides remarkably clean reactions in an inexpensive, simple, and rapid process using minimal quantities of catalyst. Overall, the synthesis of a typical catalyst and the asymmetric oxidation together takes no longer than 6 hours. Further development by modification of catalyst structure and extension to functionalized alkene substrates is now desirable. This proposal alms to improve an these initial findings and we seek to prepare improved activity catalysts and to improve the scope aid generally of the approach. We plan to develop immobilised catalysts in which the catalysts are retained on the surface of inorganic supports by electrostatic Interaction. We plan to develop a new stable, fully reusable catalyst for important oxidation reactions.