3D Fusion and Visualization of Quantified Cardiac CTCA and Nuclear Perfusion Imag

定量心脏 CTCA 和核灌注图像的 3D 融合和可视化

• 批准号: 7462231
• 负责人: TRACY L FABER
• 金额: $ 47.77万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7462231
• 关键词: Algorithms; Americas; Anatomy; Angiography; Animal Experiments; Animals; Area; Arteries; Arteriogram; Arteriographies; Cardiac; Cause of Death; Clinical; Code; Color; Computers; Coronary; Coronary Angiography; Coronary Arteriosclerosis; Coronary Stenosis; Coronary artery; Count; Data; Development; Diagnosis; Diagnostic; Epicardium; Evaluation; Gold; Heart; Heart Diseases; Human; Image; Imagery; Invasive; Left; Localized; Measurement; Mechanics; Methodology; Methods; Modality; Modeling; Morphologic artifacts; Myocardial; Myocardial perfusion; Myocardium; Nuclear; PET/CT scan; Patient Care; Patients; Perfusion; Physiological; Positron-Emission Tomography; Procedures; Quality Control; Reading; Relative (related person); Reporting; Risk; Scheme; Severities; Shapes; Slice; Spiral Computed Tomography; Standards of Weights and Measures; Surface; Techniques; Testing; Trees; Validation; Ventricular; Visual; Work; base; concept; coronary artery calcification; cost; diagnosis standard; diagnostic catheterization; human study; improved; novel strategies; single photon emission computed tomography

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) continues to be the leading cause of death in America. Coronary arteriography is the standard for diagnosing the anatomical basis of CAD: however, this invasive test has a non-negligible procedural risk and significant cost. Moreover, ~30% of coronary arteriograms show no demonstrable coronary artery stenosis, and only 1/3 are performed in conjunction with an interventional procedure. Non-invasive evaluation of coronary anatomy with multislice spiral CT coronary arteriography (CTCA) could potentially replace these diagnostic angiograms, but has limitations including image artifacts related to coronary arterial calcification and coronary stenting. Non-invasive ECG-gated myocardial perfusion imaging (MPI) provides physiologic information and is the standard for the assessment of hypoperfusion resulting from CAD; however, it also has limitations related to its measurement of flow being relative rather than absolute. We hypothesize that explicit integration of the anatomic information from CTCA and the physiologic information from MPI can ameliorate the limitations of each, improve assessment of CAD, and eliminate many diagnostic catheterizations, reserving invasive angiography primarily for interventional use. Our long term objective is to develop and validate computer-based methods to fuse, render and quantify complementary CTCA+MPI cardiac imagery. Our primary hypothesis is that 3D fusion and rendering of cardiac information from these complementary imaging modalities is more accurate and efficient in diagnosing CAD than conventional approaches of independently viewing each study. Our specific aims are to develop new methods for fusing and rendering CTCAs and MPIs that take advantage of all relevant information available in both images. The new approach segments the ventricular surfaces from the CTCA using their expected shape and intensity, and then incorporates a mechanical model to nonlinearly fuse the MPI to these surfaces. The arteries segmented from the CTCA will thus be in alignment with the transformed MPI data. Quantitative information about arterial anatomy and myocardial perfusion will be combined and displayed using surface rendered 3D graphics. This approach will be entirely automatic and much more accurate than existing techniques. All work will be validated with animal and patient studies to show both accuracy of fusion and the efficacy of reading the fused display vs. separate CTCA and MPI slices, and vs. standard angiograms.

描述（由申请人提供）：冠状动脉疾病（CAD）仍然是美国死亡的主要原因。冠状动脉造影是诊断CAD解剖基础的标准，然而，这种侵入性检查具有不可忽视的程序风险和巨大的成本。此外，约30%的冠状动脉造影未显示明显的冠状动脉狭窄，只有1/3的冠状动脉造影与介入手术同时进行。多层螺旋CT冠状动脉造影（CTCA）对冠状动脉解剖的无创评估有可能取代这些诊断性血管造影，但存在局限性，包括与冠状动脉钙化和冠状动脉支架置入术相关的图像伪影。无创心电图门控心肌灌注成像（MPI）提供生理信息，是评估CAD引起的灌注不足的标准；然而，它也有局限性，因为它的流量测量是相对的，而不是绝对的。我们假设CTCA的解剖信息和MPI的生理信息的明确整合可以改善各自的局限性，改善对CAD的评估，并消除许多诊断导管，保留侵入性血管造影主要用于介入应用。我们的长期目标是开发和验证基于计算机的方法来融合、渲染和量化互补的CTCA+MPI心脏图像。我们的主要假设是，从这些互补成像模式中获得的心脏信息的3D融合和渲染在诊断CAD时比独立查看每个研究的传统方法更准确和有效。我们的具体目标是开发融合和渲染ctca和mpi的新方法，利用两幅图像中可用的所有相关信息。新方法利用CTCA的预期形状和强度对心室表面进行分割，然后结合力学模型将MPI非线性融合到这些表面上。因此，从CTCA分割的动脉将与转换后的MPI数据一致。动脉解剖和心肌灌注的定量信息将结合并使用表面渲染的3D图形显示。这种方法将是完全自动的，而且比现有的技术要准确得多。所有工作都将通过动物和患者研究进行验证，以显示融合的准确性和读取融合显示与单独的CTCA和MPI切片以及与标准血管造影相比的有效性。