3D Fusion and Visualization of Quantified Cardiac CTCA and Nuclear Perfusion Imag

定量心脏 CTCA 和核灌注图像的 3D 融合和可视化

• 批准号: 7636744
• 负责人: TRACY L FABER
• 金额: $ 50.24万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7636744
• 关键词: Algorithms; Americas; Anatomy; Angiography; Animal Experiments; Animals; Area; Arteries; Arteriogram; Arteriographies; Cardiac; Cause of Death; Clinical; Code; Color; Computers; Coronary; Coronary Angiography; Coronary Arteriosclerosis; Coronary Stenosis; Coronary artery; Data; Development; Diagnosis; Diagnostic; Epicardium; Evaluation; Gold; Heart; Heart Diseases; Human; Image; Imagery; Left; Measurement; Mechanics; Methodology; Methods; Modality; Modeling; Morphologic artifacts; Myocardial; Myocardial perfusion; Myocardium; Nuclear; PET/CT scan; Patient Care; Patients; Perfusion; Physiological; Positron-Emission Tomography; Procedures; Quality Control; Reading; Relative (related person); Reporting; Risk; Scheme; Severities; Shapes; Slice; Spiral Computed Tomography; Surface; Techniques; Testing; Trees; Validation; Ventricular; Visual; Work; base; coronary artery calcification; cost; diagnosis standard; diagnostic catheterization; imaging modality; improved; novel strategies; single photon emission computed tomography

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) continues to be the leading cause of death in America. Coronary arteriography is the standard for diagnosing the anatomical basis of CAD: however, this invasive test has a non-negligible procedural risk and significant cost. Moreover, ~30% of coronary arteriograms show no demonstrable coronary artery stenosis, and only 1/3 are performed in conjunction with an interventional procedure. Non-invasive evaluation of coronary anatomy with multislice spiral CT coronary arteriography (CTCA) could potentially replace these diagnostic angiograms, but has limitations including image artifacts related to coronary arterial calcification and coronary stenting. Non-invasive ECG-gated myocardial perfusion imaging (MPI) provides physiologic information and is the standard for the assessment of hypoperfusion resulting from CAD; however, it also has limitations related to its measurement of flow being relative rather than absolute. We hypothesize that explicit integration of the anatomic information from CTCA and the physiologic information from MPI can ameliorate the limitations of each, improve assessment of CAD, and eliminate many diagnostic catheterizations, reserving invasive angiography primarily for interventional use. Our long term objective is to develop and validate computer-based methods to fuse, render and quantify complementary CTCA+MPI cardiac imagery. Our primary hypothesis is that 3D fusion and rendering of cardiac information from these complementary imaging modalities is more accurate and efficient in diagnosing CAD than conventional approaches of independently viewing each study. Our specific aims are to develop new methods for fusing and rendering CTCAs and MPIs that take advantage of all relevant information available in both images. The new approach segments the ventricular surfaces from the CTCA using their expected shape and intensity, and then incorporates a mechanical model to nonlinearly fuse the MPI to these surfaces. The arteries segmented from the CTCA will thus be in alignment with the transformed MPI data. Quantitative information about arterial anatomy and myocardial perfusion will be combined and displayed using surface rendered 3D graphics. This approach will be entirely automatic and much more accurate than existing techniques. All work will be validated with animal and patient studies to show both accuracy of fusion and the efficacy of reading the fused display vs. separate CTCA and MPI slices, and vs. standard angiograms.

描述（由申请人提供）：冠状动脉疾病（CAD）仍然是美国的首要死因。冠状动脉造影是诊断 CAD 解剖学基础的标准：然而，这种侵入性检查具有不可忽视的操作风险和高昂的成本。此外，约 30% 的冠状动脉造影显示没有明显的冠状动脉狭窄，并且只有 1/3 是与介入手术结合进行的。使用多层螺旋 CT 冠状动脉造影 (CTCA) 对冠状动脉解剖结构进行无创评估可能会取代这些诊断性血管造影，但存在局限性，包括与冠状动脉钙化和冠状动脉支架置入相关的图像伪影。无创心电门控心肌灌注成像 (MPI) 提供生理信息，是评估 CAD 引起的低灌注的标准；然而，它也有一些局限性，因为它的流量测量是相对的而不是绝对的。我们假设，CTCA 的解剖信息和 MPI 的生理信息的明确整合可以改善各自的局限性，改善 CAD 的评估，并消除许多诊断性导管插入术，保留侵入性血管造影主要用于介入用途。我们的长期目标是开发和验证基于计算机的方法来融合、渲染和量化互补的 CTCA+MPI 心脏图像。我们的主要假设是，与独立查看每项研究的传统方法相比，这些互补成像方式的 3D 融合和心脏信息渲染在诊断 CAD 方面更加准确和高效。我们的具体目标是开发融合和渲染 CTCA 和 MPI 的新方法，利用两幅图像中可用的所有相关信息。新方法使用预期的形状和强度从 CTCA 中分割心室表面，然后结合机械模型将 MPI 非线性地融合到这些表面。因此，从 CTCA 中分割出来的动脉将与转换后的 MPI 数据对齐。有关动脉解剖结构和心肌灌注的定量信息将使用表面渲染的 3D 图形进行组合和显示。这种方法将是完全自动的，并且比现有技术更加准确。所有工作都将通过动物和患者研究进行验证，以显示融合的准确性以及读取融合显示与单独的 CTCA 和 MPI 切片以及标准血管造影的效率。