3D Fusion and Visualization of Quantified Cardiac CTCA and Nuclear Perfusion Imag

定量心脏 CTCA 和核灌注图像的 3D 融合和可视化

• 批准号: 7844986
• 负责人: TRACY L FABER
• 金额: $ 49.61万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844986
• 关键词: Algorithms; Americas; Anatomy; Angiography; Animal Experiments; Animals; Area; Arteries; Arteriogram; Arteriographies; Cardiac; Cause of Death; Clinical; Code; Color; Computers; Coronary; Coronary Angiography; Coronary Arteriosclerosis; Coronary Stenosis; Coronary artery; Data; Development; Diagnosis; Diagnostic; Epicardium; Evaluation; Gold; Heart; Heart Diseases; Human; Image; Imagery; Left; Measurement; Mechanics; Methodology; Methods; Modality; Modeling; Morphologic artifacts; Myocardial; Myocardial perfusion; Myocardium; Nuclear; PET/CT scan; Patient Care; Patients; Perfusion; Physiological; Positron-Emission Tomography; Procedures; Quality Control; Reading; Relative (related person); Reporting; Risk; Scheme; Severities; Shapes; Slice; Spiral Computed Tomography; Surface; Techniques; Testing; Trees; Validation; Ventricular; Visual; Work; base; coronary artery calcification; cost; diagnosis standard; diagnostic catheterization; imaging modality; improved; novel strategies; single photon emission computed tomography

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) continues to be the leading cause of death in America. Coronary arteriography is the standard for diagnosing the anatomical basis of CAD: however, this invasive test has a non-negligible procedural risk and significant cost. Moreover, ~30% of coronary arteriograms show no demonstrable coronary artery stenosis, and only 1/3 are performed in conjunction with an interventional procedure. Non-invasive evaluation of coronary anatomy with multislice spiral CT coronary arteriography (CTCA) could potentially replace these diagnostic angiograms, but has limitations including image artifacts related to coronary arterial calcification and coronary stenting. Non-invasive ECG-gated myocardial perfusion imaging (MPI) provides physiologic information and is the standard for the assessment of hypoperfusion resulting from CAD; however, it also has limitations related to its measurement of flow being relative rather than absolute. We hypothesize that explicit integration of the anatomic information from CTCA and the physiologic information from MPI can ameliorate the limitations of each, improve assessment of CAD, and eliminate many diagnostic catheterizations, reserving invasive angiography primarily for interventional use. Our long term objective is to develop and validate computer-based methods to fuse, render and quantify complementary CTCA+MPI cardiac imagery. Our primary hypothesis is that 3D fusion and rendering of cardiac information from these complementary imaging modalities is more accurate and efficient in diagnosing CAD than conventional approaches of independently viewing each study. Our specific aims are to develop new methods for fusing and rendering CTCAs and MPIs that take advantage of all relevant information available in both images. The new approach segments the ventricular surfaces from the CTCA using their expected shape and intensity, and then incorporates a mechanical model to nonlinearly fuse the MPI to these surfaces. The arteries segmented from the CTCA will thus be in alignment with the transformed MPI data. Quantitative information about arterial anatomy and myocardial perfusion will be combined and displayed using surface rendered 3D graphics. This approach will be entirely automatic and much more accurate than existing techniques. All work will be validated with animal and patient studies to show both accuracy of fusion and the efficacy of reading the fused display vs. separate CTCA and MPI slices, and vs. standard angiograms.

描述（由申请人提供）：冠状动脉疾病（CAD）仍然是美国死亡的主要原因。冠状动脉造影是诊断CAD解剖基础的标准：但是，这种侵入性测试具有不可忽略的程序风险和显着的成本。此外，约有30％的冠状动脉造影症没有显示出明显的冠状动脉狭窄，并且仅与介入程序一起进行1/3。对具有多层螺旋CT冠状动脉造影术（CTCA）的冠状动脉解剖结构的非侵入性评估可能会替代这些诊断血管造影，但具有局限性，包括与冠状动脉动脉钙化和冠状动脉支架相关的图像伪影。非侵入性ECG门控的心肌灌注成像（MPI）提供了生理信息，并且是评估CAD引起的炎症的标准。但是，它也具有与其流量相对而不是绝对的限制有关的局限性。我们假设来自CTCA的解剖信息的明确整合以及MPI的生理信息可以改善每个信息的局限性，改善CAD的评估并消除许多诊断导管插入，从而保留主要用于介入的侵入性血管造影。我们的长期目标是开发和验证基于计算机的方法来融合，渲染和量化互补的CTCA+MPI心脏图像。我们的主要假设是，来自这些互补成像方式的3D融合和心脏信息的渲染在诊断CAD方面比独立查看每项研究的常规方法更准确，更有效。我们的具体目的是开发融合和渲染CTCA和MPI的新方法，以利用这两个图像中可用的所有相关信息。新方法使用其预期的形状和强度将心室表面从CTCA段段，然后将机械模型纳入非线性将MPI融合到这些表面上。因此，从CTCA分割的动脉将与转换后的MPI数据保持一致。有关动脉解剖结构和心肌灌注的定量信息将使用表面渲染的3D图形组合和显示。与现有技术相比，这种方法将完全是自动的，并且更准确。所有工作都将通过动物和患者研究来验证，以显示融合的准确性以及阅读融合显示的功效，与单独的CTCA和MPI切片以及与标准血管造影相比。