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A Mature Brain Architecture Knowledge Management System

成熟的大脑架构知识管理系统

基本信息

批准号：
7625335
负责人：
LARRY W SWANSON
金额：
$ 42.32万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7625335
关键词：
Architecture Biological Biological Neural Networks Body of uterus Brain Cells Chemicals Classification Collaborations Communities Complement Complex Data Data Set Data Sources Databases Development Disease model Emotions Epilepsy Foundations Funding Goals Grant Graph Hand Health Human Hypothalamic structure Information Resources Management Institutes International Learning Limbic System Literature Localized Macaca Memory Metadata Methods Microscopy Modeling Motivation Multiple Sclerosis Nervous System Part Nervous system structure Neuraxis Neurons Neurosciences Neurosciences Research Numbers Online Systems Ontology Pathway Analysis Pathway interactions Publishing Range Rattus Recommendation Reporting Research Spinal Cord Staging Standards of Weights and Measures Strigiformes Stroke Structure Structure-Activity Relationship System Text Vertebral column Work cell type chronic pain database design gray matter nervous system disorder neural circuit neuroinformatics programs prototype relating to nervous system white matter

项目摘要

The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer¿s, chronic pain, epilepsy, multiple sclerosis, Parkinson¿s, and stroke. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules.

拟议研究的长期目标是创建一个功能齐全的在线工作台，用于获取有关构成大脑的生物回路的信息，以及用于模拟大脑功能组织的信息这种回路与健康和广泛的神经系统疾病有关，包括阿尔茨海默病、慢性疼痛、癫痫、多发性硬化症、帕金森病和中风。这种方法在早期阶段的优势之一是发展在于它补充了实验室中的实验系统神经科学研究边缘系统电路的基本结构和化学组织，控制基本驱动和情绪，以及学习和记忆。这里提出的神经信息学研究的基础是一个功能齐全、使用相对频繁的网站，始于 2001 年，名为 Brain Architecture Knowledge 管理系统（谷歌：BAMS）。它是目前唯一集成神经科学的在线系统四个组织层次的信息：灰质区域、构成区域的神经元细胞类型、白质物质轴突区域和细胞类型之间的连接以及表达分子。