A Mature Brain Architecture Knowledge Management System

拟议研究的长期目标是创建一个功能齐全的在线工作台，以获得 关于组成大脑的生物回路的信息，以及用于对 这种回路在健康和一系列神经系统疾病中都有，包括阿尔茨海默氏症、慢性疼痛、 癫痫、多发性硬化症、帕金森氏症、S和中风。这种方法在早期阶段的一个优点是 它的发展是对实验室中实验系统神经科学研究的补充 边缘系统电路的基本结构和化学组织，它控制基本的驱动和 情绪，以及学习和记忆。这里提出的神经信息学研究的基础是 这是一个运行正常、使用率相对较高的网站，始建于2001年，名为大脑架构知识 管理系统(Google：BAMS)。它是目前唯一一个集成了神经科学的在线系统 四个层次的组织信息：灰质区域、组成区域的神经细胞类型、白色 物质轴突连接的区域和细胞类型，以及表达的分子。

The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer¿s, chronic pain, epilepsy, multiple sclerosis, Parkinson¿s, and stroke. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules.