A Mature Brain Architecture Knowledge Management System

描述(申请人提供)：这项拟议研究的长期目标是创建一个功能齐全的在线工作台，用于获取组成大脑的生物回路的信息，并在健康和广泛的神经疾病中模拟这种回路的功能组织，包括阿尔茨海默氏症、慢性疼痛、癫痫、多发性硬化症、帕金森氏症、中风和发作性睡病。这种方法在早期开发阶段的一个优势是，它补充了实验室中关于边缘系统回路的基本结构和化学组织的实验系统神经科学研究，边缘系统回路控制着基本的驱动和情绪，以及学习和记忆。这里提出的神经信息学研究的基础是一个功能正常、使用相对频繁的网站，始于2001年，名为大脑架构知识管理系统(Google：BAMS)。它是目前唯一一个在四个组织层次上整合神经科学信息的在线系统：灰质区域、组成区域的神经元细胞类型、区域和细胞类型之间的白质轴突连接以及表达的分子。公共卫生相关性：所有主要的神经系统疾病都是在动物模型中进行研究的，包括大鼠。这项拟议研究的目标是创建一个被广泛使用的在线网站，用于获取与健康和疾病有关的大脑电路和系统的结构和化学信息，并对大脑的基本接线图以及在以特定方式治疗的特定神经疾病中它是如何受到影响的进行建模。

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer's, chronic pain, epilepsy, multiple sclerosis, Parkinson's, stroke, and narcolepsy. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules. PUBLIC HEALTH RELEVANCE: All of the major neurological diseases are studied in animal models including rat. The goal of the proposed research is to create a widely used online website for accessing information about the structure and chemistry of brain circuits and systems involved in health and disease, and for modeling the basic wiring diagram of the brain and how it is affected in specific neurological diseases, treated in specific ways.