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Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease

Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease
同源域 Nkx2-5 依赖性负反馈环在心脏发育和先天性心脏病中很重要
批准号:
nhmrc : 573703
负责人:
Prof Richard Harvey
金额:
$88.7万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2013-12-31

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中文摘要
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英文摘要
Congenital heart disease (CHD) is the cause of most deaths in children in the first year of life. We have identified a genetic pathway important for both normal cardiac development and CHD that involves the cardiac transcription factor Nkx2-5. This pathway controls a transition in embryos between cardiac cell specification and expansion. We will now explore the biochemical and genetic mechanisms underlying this pathway to help us understand CHD and identify its causative genes.
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Genetic, Cellular and Molecular Analysis of Cardiac Ventricular Septation
  • 批准号:
    DP210102134
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $56.57万
  • 财政年份:
    2021
  • 负责人:
    Prof Richard Harvey
  • 依托单位:
Endocardial sprouting and mechano-signalling in heart trabeculation
  • 批准号:
    DP190101475
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $38.26万
  • 财政年份:
    2019
  • 负责人:
    Prof Richard Harvey
  • 依托单位:
Molecular Approaches to Cardiac Development, Disease and Regeneration
  • 批准号:
    nhmrc : GNT1118576
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $86.39万
  • 财政年份:
    2017
  • 负责人:
    Prof Richard Harvey
  • 依托单位:
Molecular Approaches to Cardiac Development, Disease and Regeneration
  • 批准号:
    nhmrc : 1118576
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $59.07万
  • 财政年份:
    2017
  • 负责人:
    Prof Richard Harvey
  • 依托单位:
海外基金