Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease

同源域 Nkx2-5 依赖性负反馈环在心脏发育和先天性心脏病中很重要

• 批准号: nhmrc : 573703
• 负责人: Prof Richard Harvey
• 金额: $ 88.7万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/homeodomain-nkx2-5-heart-disease/83048
• 关键词: Homeodomain; Nkx2; dependent; negative; feedback

Congenital heart disease (CHD) is the cause of most deaths in children in the first year of life. We have identified a genetic pathway important for both normal cardiac development and CHD that involves the cardiac transcription factor Nkx2-5. This pathway controls a transition in embryos between cardiac cell specification and expansion. We will now explore the biochemical and genetic mechanisms underlying this pathway to help us understand CHD and identify its causative genes.

先天性心脏病(CHD)是大多数儿童在出生一年内死亡的原因。我们已经确定了一条对正常心脏发育和CHD都很重要的遗传途径，它涉及心脏转录因子Nkx2-5。这一途径控制着胚胎在心脏细胞规范和扩增之间的过渡。我们现在将探索这一途径背后的生化和遗传机制，以帮助我们了解CHD并确定其致病基因。