Gene regulatory networks in heart development

心脏发育中的基因调控网络

• 批准号: DP0988507
• 负责人: Prof Richard Harvey
• 金额: $ 31.88万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988507
• 关键词: Gene; regulatory; networks; heart; development

In humans, structural and functional malformations of the heart are very common and are associated with a high economic and emotional burden. In this project, we will study how genetic networks initiate and control heart development at a molecular level. We will establish and employ state-of-the-art technologies and bioinformatics tools to explore the function of cardiac regulatory genes in detail. Our work will contribute both to discover new cardiac pathways for a better understanding of heart formation and disease, and to develop advanced techniques that will contribute to strengthen Australian basic and strategic research.

在人类中，心脏的结构和功能畸形是非常常见的，并与高度的经济和情感负担有关。在这个项目中，我们将研究基因网络如何在分子水平上启动和控制心脏发育。我们将建立并运用最先进的技术和生物信息学工具来详细探索心脏调节基因的功能。我们的工作将有助于发现新的心脏途径，以更好地了解心脏形成和疾病，并开发有助于加强澳大利亚基础和战略研究的先进技术。