Molecular mechanisms of stem cell self-renewal.
Molecular mechanisms of stem cell self-renewal.
批准号:
DP0346726
负责人:
Prof Richard Harvey
金额:
$16.75万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-01-01 至 2005-12-31
中文摘要
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英文摘要
Muscle growth and regeneration is critically dependent on its stem cell compartment. We have discovered that the p38 MAPK pathway is essential for stem cell self-renewal in the C2C12 myogenic cell line. This proposal seeks to understand the molecular basis of stem cell self-renewal in skeletal muscles, data that may be applicable to many stem cell systems, and to the enormous promise of stem cell therapies for injury and diseases of the aged. We will attempt to alter the balance of stem cell production by enforced p38 expression, and take microarray and proteomics approaches to define stem cell pathways.
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负责人:Prof Richard Harvey
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依托单位:
Molecular Approaches to Cardiac Development, Disease and Regeneration
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批准号:nhmrc : 1118576
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项目类别:Research Fellowships
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资助金额:$59.07万
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财政年份:2017
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Sprouting Angiogenesis and its Role in Development of Chamber Myocardium
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项目类别:Discovery Projects
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资助金额:$32.76万
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财政年份:2016
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依托单位:
Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease
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批准号:nhmrc : 573703
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资助金额:$88.7万
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负责人:Prof Richard Harvey
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依托单位:
Gene regulatory networks in heart development
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批准号:DP0988507
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资助金额:$31.88万
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财政年份:2009
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依托单位:
Australia Fellowship
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批准号:nhmrc : 573705
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项目类别:NHMRC Research Fellowships
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资助金额:$266.72万
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财政年份:2009
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负责人:Prof Richard Harvey
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依托单位:
Control of transcription by the cardiac homeodomain protein Nkx2-5
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批准号:DP0212000
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项目类别:Discovery Projects
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资助金额:$16.13万
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财政年份:2002
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负责人:Prof Richard Harvey
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依托单位:
Leica Microtome RM21325
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批准号:nhmrc : 1520
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项目类别:NHMRC Infrastructure Grants
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资助金额:$0.63万
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财政年份:2000
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负责人:Prof Richard Harvey
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依托单位:
Role of Homeobox Gene Nkx2-5 in Heart Development and Congenital Heart Disease
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批准号:nhmrc : 109002
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项目类别:NHMRC Project Grants
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资助金额:$15.16万
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财政年份:2000
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负责人:Prof Richard Harvey
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依托单位:
The signalling antagonist mCer-1 and its role in development of brain and heart in mouse embryos
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批准号:nhmrc : 990689
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项目类别:NHMRC Project Grants
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资助金额:$25.48万
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负责人:Prof Richard Harvey
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依托单位:
The characterisation and functional analysis of a novel Nkx2.5-regulated gene in cardiac and skeletal muscle.
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批准号:nhmrc : 990874
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项目类别:NHMRC Project Grants
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资助金额:$17.19万
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财政年份:1999
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负责人:Prof Richard Harvey
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依托单位:
国内基金
海外基金
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