Endocardial sprouting and mechano-signalling in heart trabeculation

心脏小梁形成中的心内膜出芽和机械信号传导

• 批准号: DP190101475
• 负责人: Prof Richard Harvey
• 金额: $ 38.26万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101475
• 关键词: Endocardial; sprouting; mechano; signalling; heart

This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation using high resolution, single cell methodologies, and to investigate how bio-mechanical forces from contraction or blood flow influence chambers formation.

该项目旨在了解心室，哺乳动物心脏的泵室，如何在胚胎生命期间形成。关键是小梁的精细化，小梁是在心室壁的内表面上形成海绵状层的心肌突起，在收缩、氧气和营养交换、传导和分隔中发挥重要作用。该项目预计将使用高分辨率，单细胞方法对小梁形成有更深入的了解，并研究收缩或血流的生物机械力如何影响室的形成。