Endocardial sprouting and mechano-signalling in heart trabeculation

这个项目旨在了解哺乳动物心脏的泵室是如何在胚胎生命中形成的。关键是小梁的形成，小梁是心肌突起，在室壁内表面形成一层海绵状的层，在收缩、氧气和营养交换、传导和隔膜中发挥重要作用。该项目希望使用高分辨率的单细胞方法对小梁形成有更深入的了解，并调查收缩或血流产生的生物机械力如何影响小梁的形成。

This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation using high resolution, single cell methodologies, and to investigate how bio-mechanical forces from contraction or blood flow influence chambers formation.