Sprouting Angiogenesis and its Role in Development of Chamber Myocardium

发芽血管生成及其在心室心肌发育中的作用

• 批准号: DP160104858
• 负责人: Prof Richard Harvey
• 金额: $ 32.76万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104858
• 关键词: Sprouting; Angiogenesis; its; Role; Development

The project aims to investigate how heart chambers form by testing the hypothesis that morphogenesis of the muscular walls of the heart is regulated during development by a Notch signalling-dependent process akin to angiogenic sprouting in other vascular beds. The project outcomes may have implications for diagnosis of congenital heart disease and for the fields of cardiac tissue engineering and regeneration. The project plans to elucidate cellular and molecular pathways underlying heart chamber development in mice using contemporary genetic methods, molecular embryology and imaging. Benefits may include a new framework for understanding heart development and disease, and the future application of this knowledge to translational cardiology.

该项目旨在通过测试心脏肌壁的形态发生在发育过程中由Notch信号依赖过程调节的假设来研究心室是如何形成的，类似于其他血管床的血管新生发芽。该项目的成果可能对先天性心脏病的诊断以及心脏组织工程和再生领域产生影响。该项目计划利用现代遗传方法、分子胚胎学和成像技术，阐明小鼠心脏腔发育的细胞和分子途径。益处可能包括了解心脏发育和疾病的新框架，以及未来将这些知识应用于转化心脏病学。