Genetic, Cellular and Molecular Analysis of Cardiac Ventricular Septation

心室间隔的遗传、细胞和分子分析

• 批准号: DP210102134
• 负责人: Prof Richard Harvey
• 金额: $ 56.57万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-08-31 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102134
• 关键词: Genetic; Cellular; Molecular; Analysis; Cardiac

The project aims to define the blueprint for ventricular septation in the mammalian heart – how, during heart development, a single ventricle becomes divided in two by a muscular wall, thus creating left and right pumps and electrical circuits serving the body and lung circulations separately. A proprietary mouse genetic model was created and will be used to probe the cellular and molecular mechanisms of septation using new technologies able to resolve biology at a single-cell level. Outcomes may include new knowledge on heart development and evolution, including how the cardiac electrical system is formed, and how cell boundaries and tissue complexity are generated. The project may advance new technologies and create new data resources.

该项目旨在定义哺乳动物心脏心室分隔的蓝图-在心脏发育过程中，单个心室如何被肌肉壁分成两部分，从而创建分别为身体和肺循环服务的左右泵和电路。创建了一个专有的小鼠遗传模型，并将用于使用能够在单细胞水平上解决生物学问题的新技术来探测分隔的细胞和分子机制。结果可能包括心脏发育和进化的新知识，包括心脏电系统如何形成，以及细胞边界和组织复杂性如何产生。该项目可以推进新技术并创建新的数据资源。