2008-2010 Lysosomes & Endocytosis Gordon Research Conference

描述（由申请人提供）：本提案要求为两次关于溶酶体和内吞作用的连续会议提供部分资助，这两次会议是戈登研究会议系列的一部分，将于2008年6月22日至27日在新罕布什尔州安多弗的普罗克特学院举行，并于2010年6月底再次举行。这个会议有四十年的传统，作为介绍内吞途径中膜运输领域前沿研究的场所。近年来，内吞途径在新的领域如发育、胞质分裂、信号传导、病原体免疫、生长控制和遗传疾病中起着重要作用。这给了主席和副主席一个很好的机会，提前计划，包括新的方向的方案。因此，我们正在为2008年和2010年的会议申请资金，以便计划纳入新的领域，协调基本途径与疾病状态，包括肌肉疾病、发育缺陷、神经缺陷和癌症，以及感染和免疫。本次会议的目的是聚集40位发言人和8位讨论负责人，代表内吞作用和溶酶体生物学研究的关键领域，并探索新的相关研究领域。2008年的计划将有一个主题演讲和8个会议，包括内吞途径的不同阶段，溶酶体在疾病中的作用，病原体抗性和发育生物学。15名发言人将从提交的摘要中选出，一个会议将专门讨论新的方向。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。对于2010年的会议，计划是扩大对肌肉疾病中的膜运输和内吞途径在癌症中的作用的关注，并继续包括感染和免疫以及溶酶体疾病。该申请的意义在于，溶酶体和内吞GRC是该领域的关键国际会议。该主题对人类健康有明显的影响，内吞途径在病毒进入，病原体抗性和溶酶体相关疾病中发挥作用，以及最近对发育，肌病和癌症的影响。

DESCRIPTION (provided by applicant): This proposal requests funding for partial support for two sequential meetings on Lysosomes and Endocytosis as part of the Gordon Research Conference series to be held in Proctor Academy, Andover, NH from June 22-27th 2008 and again at the end of June 2010. This conference has a tradition of forty years as a venue for presentation of cutting edge research in the area of membrane traffic in the endocytic pathway. In recent years it has become apparent that the endocytic pathway plays important roles in new areas such as development, cytokinesis, signalling, immunity to pathogens, growth control and genetic diseases. This gives the Chair and Vice Chair an excellent opportunity to plan ahead to include new directions in the programs. We are therefore applying for funding for the 2008 and 2010 meetings, in order to plan to include new areas coordinating the basic pathways with disease states including, muscle disease, developmental defects, neurological defects and cancer, as well as infection and immunity. The aim of this meeting is to gather a total of 40 speakers and 8 discussion leaders, representing critical areas in research in endocytosis and lysosome biology and explore novel related areas of research. The program for 2008 will have a keynote presentation and 8 sessions encompassing different stages of the endocytic pathway, the role of the lysosome in disease, pathogen resistance and developmental biology.15 speakers will be selected from abstracts submitted and one session will be devoted to discussion of new directions. In addition, two evening poster sessions will permit all participants to contribute to these topics. For the 2010 conference, the plan is to expand the focus on membrane traffic in muscle disease and the role of the endocytic pathway in cancer, as well as continue to include infection and immunity and lysosomal diseases. The significance of this application is that the Lysosomes and Endocytosis GRC is the key international meeting in this field. The topic has a clear impact on human health with the endocytic pathway playing a role in viral entry, pathogen resistance and lysosome-related diseases, as well as recent implications for development, myopathy and cancer.