MAPPING INTERACTIVE CANCER SUSCEPTIBILITY GENES IN PROSTATE CANCER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是从患有前列腺癌的兄弟对中收集血液，以便进行实验室研究。这些实验室研究将寻找可能影响前列腺癌风险的基因（可以遗传的因素）。 癌症研究人员最近确定了几个生物因素，可能是重要的前列腺癌的发展。 研究人员将确定20多个遗传因素在癌症研究中的作用。我们还将专门研究这些遗传因素与患前列腺癌的风险之间是否存在任何关系。癌症研究人员已经认识到，由于遗传基因，患癌症的风险可能会增加。有时风险可能很大;有时风险相对较小。我们正在研究许多对癌症风险贡献较弱的基因是否可以相互作用产生强烈的风险。 本研究的目的是在整个人类基因组中最有可能影响前列腺癌遗传风险的大约25个候选基因座处收集等位基因共享统计数据，对显示连锁证据的候选基因/区域进行精细结构多点分析，做一个标记-用于测试疾病中基因X基因相互作用的指导策略，并在适当的患者亚群中鉴定候选基因内的疾病变体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect blood from pairs of brothers with prostate cancer in order to do laboratory studies. These laboratory studies will look for genes (factors that can be inherited) that might influence the risk of prostate cancer. Cancer researchers have recently identified several biological factors that may be important in the development of prostate cancer. Researchers will determine the role of more than two dozen genetic factors in cancer research. We will also specifically study whether there is any relationship between any of these genetic factors and the risk of developing prostate cancer. Cancer researchers have come to appreciate that the risk of getting cancer may be increased because of inherited genes. Sometimes the risk can be very strong; sometimes the risk is relatively weak. We are studying whether many genes with weak contributions to cancer risk can interact to produce a strong risk. The purpose of this study is to gather allele-sharing statistics at approximately 25 candidate loci throughout the human genome most likely to influence genetic risk of prostate cancer, to perform fine structure multipoint analysis for candidate genes/regions showing suggestive evidence for linkage, to perform a marker-guided strategy for testing gene x gene interactions in disease and to identify disease variants within candidate genes in appropriate patient subsets.