MAPPING INTERACTIVE CANCER SUSCEPTIBILITY GENES IN PROSTATE CANCER

绘制前列腺癌中相互作用的癌症易感基因图谱

• 批准号: 7716644
• 负责人: THEODORE G KRONTIRIS
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716644
• 关键词: Alleles; Biological Factors; Blood; Brothers; Cancer-Predisposing Gene; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Genes; Genetic; Genetic Epistasis; Genetic Risk; Grant; Human Genome; Inherited; Institution; Laboratory Study; Malignant Neoplasms; Malignant neoplasm of prostate; Maps; Patients; Purpose; Research; Research Personnel; Resources; Risk; Role; Source; Structure; Testing; United States National Institutes of Health; Variant; anticancer research; cancer risk; genetic risk factor; research study; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect blood from pairs of brothers with prostate cancer in order to do laboratory studies. These laboratory studies will look for genes (factors that can be inherited) that might influence the risk of prostate cancer. Cancer researchers have recently identified several biological factors that may be important in the development of prostate cancer. Researchers will determine the role of more than two dozen genetic factors in cancer research. We will also specifically study whether there is any relationship between any of these genetic factors and the risk of developing prostate cancer. Cancer researchers have come to appreciate that the risk of getting cancer may be increased because of inherited genes. Sometimes the risk can be very strong; sometimes the risk is relatively weak. We are studying whether many genes with weak contributions to cancer risk can interact to produce a strong risk. The purpose of this study is to gather allele-sharing statistics at approximately 25 candidate loci throughout the human genome most likely to influence genetic risk of prostate cancer, to perform fine structure multipoint analysis for candidate genes/regions showing suggestive evidence for linkage, to perform a marker-guided strategy for testing gene x gene interactions in disease and to identify disease variants within candidate genes in appropriate patient subsets.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是从患有前列腺癌的兄弟成对以进行实验室研究。这些实验室研究将寻找可能影响前列腺癌风险的基因（可以遗传的因素）。 癌症研究人员最近确定了几种在前列腺癌发展中可能很重要的生物学因素。 研究人员将确定二十多个遗传因素在癌症研究中的作用。我们还将专门研究这些遗传因素中的任何一个与发展前列腺癌的风险之间是否存在任何关系。癌症研究人员已经意识到，由于遗传基因，可能会增加患癌症的风险。有时，风险可能非常强烈；有时，风险相对较弱。我们正在研究许多对癌症风险贡献较弱的基因是否可以相互作用以产生强大的风险。 这项研究的目的是在最有可能影响前列腺癌遗传风险的大约25个候选基因群上收集等位基因共同的统计数据，以对候选基因/区域进行精细的结构多点分析，以表明有暗示性的链接证据，以执行标记指导的策略，以在疾病中测试疾病中的基因相互作用，并在疾病中识别候选患者中的疾病中的基因相互作用。