MAPPING INTERACTIVE CANCER SUSCEPTIBILITY GENES IN PROSTATE CANCER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究性研究的目的是采集一对前列腺癌兄弟的血液，以便进行实验室研究。这些实验室研究将寻找可能影响前列腺癌风险的基因(可遗传因素)。癌症研究人员最近确定了几个可能在前列腺癌发展过程中起重要作用的生物因素。 研究人员将确定二十多种遗传因素在癌症研究中的作用。我们还将具体研究这些遗传因素是否与患前列腺癌的风险之间存在任何关系。癌症研究人员已经认识到，遗传基因可能会增加患癌症的风险。有时风险很大，有时风险相对较弱。我们正在研究许多对癌症风险贡献较弱的基因是否可以相互作用，产生较强的风险。 这项研究的目的是收集人类基因组中大约25个最有可能影响前列腺癌遗传风险的候选基因的等位基因共享统计数据，对候选基因/区域进行精细结构多点分析，显示有可能存在连锁的证据，执行标记引导的策略来测试疾病中基因x基因的相互作用，并在适当的患者亚群中识别候选基因中的疾病变异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect blood from pairs of brothers with prostate cancer in order to do laboratory studies. These laboratory studies will look for genes (factors that can be inherited) that might influence the risk of prostate cancer. Cancer researchers have recently identified several biological factors that may be important in the development of prostate cancer. Researchers will determine the role of more than two dozen genetic factors in cancer research. We will also specifically study whether there is any relationship between any of these genetic factors and the risk of developing prostate cancer. Cancer researchers have come to appreciate that the risk of getting cancer may be increased because of inherited genes. Sometimes the risk can be very strong; sometimes the risk is relatively weak. We are studying whether many genes with weak contributions to cancer risk can interact to produce a strong risk. The purpose of this study is to gather allele-sharing statistics at approximately 25 candidate loci throughout the human genome most likely to influence genetic risk of prostate cancer, to perform fine structure multipoint analysis for candidate genes/regions showing suggestive evidence for linkage, to perform a marker-guided strategy for testing gene x gene interactions in disease and to identify disease variants within candidate genes in appropriate patient subsets.