The Heritability of Purging and Purging Disorder in a Sample of Female Twins

女性双胞胎样本中净化和净化障碍的遗传力

• 批准号: 7546418
• 负责人: SARA E TRACE
• 金额: $ 3.02万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-02 至 2009-07-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7546418
• 关键词: Anorexia Nervosa; Awareness; Behavior; Behavioral Genetics; Binge Eating; Body Weight; Bulimia; Categories; Cessation of life; Computer software; Data; Data Set; Diagnostic; Disease; Diuretics; Eating; Eating Disorders; Environment; Environmental Risk Factor; Exercise; Female; Genes; Genetic; Heritability; Hyperphagia; Intervention; Lead; Learning; Literature; Measurable; Mediating; Medical; Mental disorders; Modeling; Morbidity - disease rate; Not Otherwise Specified; Phenotype; Population; Prevalence; Prevention; Purpose; Rate; Recurrence; Reporting; Research; Research Training; Sampling; Self Concept; Societies; Statistical Methods; Symptoms; Twin Multiple Birth; Twin Studies; Vomiting; Weight maintenance regimen; Woman; base; cohort; excessive behavior; experience; falls; genetic epidemiology; insight; interest; laxative; model design; programs; psychologic; purge; response; transmission process

DESCRIPTION (provided by applicant): Over the past decade, considerable advances have been made in understanding genetic influences on disordered eating. Of particular interest are differential heritability estimates of specific symptoms within each eating disorder diagnostic category. The varying contributions of genes and environment to symptoms within a single diagnostic entity suggests that current research should focus on the symptom level, rather than the diagnostic level, in order to understand the genetic origins of disordered eating and inform treatment interventions. Purging is a highly heritable and readily measurable symptom of eating disorders. Purging can include self-induced vomiting, laxative use, or use of other substances. In addition, although it is classified as a no purging symptom, excessive exercise is a dangerous weight control behavior. Despite the fact that purging is associated with physical and psychological morbidity, only one study has examined the heritability of purging as a distinct phenotype and no studies have examined excessive exercise. Recently, a newly described eating disorder presentation, purging disorder (PD), has been proposed. PD is defined as recurrent purging in the absence of binge episodes. PD currently falls under eating disorder not otherwise specified and may lead to severe medical consequences, including death. To date, little research has examined the prevalence and heritability of PD in large, population-based samples. Understanding genetic factors associated with purging and PD is important, as these factors can influence how eating disorders are recognized, researched, and treated. Insight into familial transmission of many psychiatric disorders has been informed by studies of twins. Thus, the aims of this study are to assess the prevalence of purging behaviors and PD in a large cohort of female twins and to estimate the genetic and environmental contributions to purging behaviors and to PD This project will fill a gap in the research literature by examining the prevalence and heritability of purging behaviors and PD in a large population-based sample of female twins. Learning more about the genetic epidemiology of purging and PD could lead to a greater understanding of core components of eating disorders while helping focus prevention and treatment on environmentally mediated symptoms.

描述（由申请人提供）：在过去的十年中，在了解基因对饮食失调的影响方面取得了相当大的进展。特别令人感兴趣的是每种饮食失调诊断类别中特定症状的差异遗传性估计。在单一诊断实体中，基因和环境对症状的不同贡献表明，目前的研究应侧重于症状水平，而不是诊断水平，以便了解饮食失调的遗传起源并为治疗干预提供信息。排便是一种高度遗传且易于测量的饮食失调症状。清除可包括自我诱导呕吐、使用泻药或使用其他物质。此外，虽然它被归类为无净化症状，但过度运动是一种危险的体重控制行为。尽管排便与生理和心理疾病有关，但只有一项研究将排便作为一种独特的表型进行了遗传研究，而且没有研究对过度运动进行了研究。最近，一种新的饮食失调的描述，泻性障碍（PD），已被提出。PD被定义为在没有暴食发作的情况下经常性的排便。PD目前属于进食障碍，没有特别说明，可能导致严重的医疗后果，包括死亡。迄今为止，很少有研究在大型人群样本中检查PD的患病率和遗传性。了解与排便和PD相关的遗传因素是很重要的，因为这些因素可以影响如何识别、研究和治疗饮食失调。通过对双胞胎的研究，我们了解了许多精神疾病的家族性传播。因此，本研究的目的是评估大量女性双胞胎中净化行为和帕金森病的患病率，并估计遗传和环境对净化行为和帕金森病的贡献。该项目将通过研究以大量人群为基础的女性双胞胎中净化行为和帕金森病的患病率和遗传性来填补研究文献中的空白。了解更多关于排便和PD的遗传流行病学知识，可以更好地了解饮食失调的核心组成部分，同时有助于将预防和治疗重点放在环境介导的症状上。