Neural Substrates of Emotional Eating

情绪化饮食的神经基础

• 批准号: 7541078
• 负责人: Cara Bohon
• 金额: $ 3.65万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-11 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7541078
• 关键词: Affect; Age; Anterior; Binge Eating; Brain; Brain imaging; Bulimia; Chocolate; Condition; Consumption; Cues; Eating; Emotional; Emotions; Expectancy; Female; Flavoring; Follow-Up Studies; Food; Food deprivation (experimental); Functional Magnetic Resonance Imaging; Hour; Imaging Techniques; Individual; Intervention; Modeling; Moods; Obesity; Participant; Pathology; Prevention; Prospective Studies; Public Health; Regulation; Relative (related person); Research; Risk; Risk Factors; Satiation; Score; Signal Transduction; Solutions; Taste Perception; Testing; base; deprivation; design; experience; food craving; frontal lobe; hedonic; improved; indexing; model development; negative mood; relating to nervous system; response; university student

DESCRIPTION (provided by applicant): The primary aim of the proposed study is to investigate key assumptions of the Affect Regulation Model of binge eating using brain imaging techniques to examine neural substrates that may explain why emotional eaters binge eat. A preliminary fMRI study suggested that emotional eaters experience greater wanting (craving) for food when in a negative mood state than non-emotional eaters (as indexed by greater activation of the anterior cingulate), but the study did not have consistent findings for the effect of mood and emotional eating on liking food (hedonics). In the proposed follow-up study, 50 female college students who score in the top or bottom quartiles of an emotional eating scale will participate in a paradigm designed to assess wanting and liking of food. In this fMRI paradigm, participants are told that particular pictures signal the impending delivery of chocolate milkshake or a tasteless control solution, but the flavors are not always actually delivered, which permits an examination of brain activation in response to anticipated and actual receipt of the milkshake. Participants will complete this task in a negative and neutral mood (order counterbalanced), to test the hypotheses that wanting and liking differences between groups are more pronounced in the latter. They will also complete the task after moderate caloric deprivation or after consumption of a standardized meal (order counterbalanced), to test the hypothesis that differences in wanting and liking between groups may be more pronounced under conditions of satiety (as food deprivation may induce a ceiling effect for wanting and liking). PUBLIC HEALTH RELEVANCE: Understanding the neural basis for emotional eating, a risk factor for bulimia nervosa, binge eating, and obesity, may have important implications for etiologic models, and the development of more effective prevention and treatment interventions for these pernicious problems.

描述（由申请人提供）：拟议研究的主要目的是使用脑成像技术研究暴食的情感调节模型的关键假设，以检查可能解释情绪化进食者暴食原因的神经基质。一项初步的功能磁共振成像研究表明，情绪化进食者在处于消极情绪状态时比非情绪化进食者更渴望食物（前扣带回的激活程度更高），但该研究没有一致的结果表明情绪和情绪化进食对喜欢食物（享乐）的影响。在拟议的后续研究中，50名在情绪化饮食量表中得分最高或最低的四分之一的女大学生将参加一个旨在评估对食物的需求和喜好的范例。在这个功能性磁共振成像范例中，参与者被告知特定的图片预示着即将到来的巧克力奶昔或无味的对照溶液，但味道并不总是真正传递，这允许检查大脑对预期和实际接收奶昔的反应。参与者将在消极和中性的情绪（秩序平衡）中完成这项任务，以测试群体之间的愿望和喜好差异在后者中更明显的假设。他们还将在中度热量剥夺或标准化膳食（顺序平衡）消耗后完成任务，以测试以下假设：在饱腹感条件下，组间的欲望和喜好差异可能更明显（因为食物剥夺可能会导致欲望和喜好的天花板效应）。公共卫生相关性：了解情绪化进食的神经基础，神经性贪食症，暴饮暴食和肥胖的危险因素，可能对病因学模型以及开发更有效的预防和治疗干预措施具有重要意义。