Genetic Dissection of a Motor Central Pattern Generator

运动中枢模式发生器的基因剖析

• 批准号: 7340123
• 负责人: John D Boughter
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340123
• 关键词: Animals; Appointment; Behavior; Behavioral; Biological Neural Networks; Brain Stem; Candidate Disease Gene; Chromosome Mapping; Complex; Data; Disease; Dissection; Gene Targeting; Genes; Genetic; Genotype; Health Sciences; Human; Inbred Strain; Inbred Strains Mice; Investigation; Knowledge; Lead; Liquid substance; Location; Maps; Measures; Modeling; Molecular; Motor; Movement; Mus; Nature; Numbers; Physiological; Plastics; Quantitative Trait Loci; Rate; Rattus; Recombinants; Resources; Reticular Formation; Rodent; Single Nucleotide Polymorphism; Skeletal Muscle; Source; Stereotyped Behavior; Stereotyping; Tennessee; Testing; Thinking; Tongue; Universities; Variant; base; central pattern generator; density; genetic resource; high throughput screening; insight; interest; jaw movement; novel; progenitor; relating to nervous system; response; trait

Central pattern generators (CPGs) are rhythmically active neural networks that underlie many stereotyped and repetitive voluntary muscle movements such as whisking or fluid licking. Fluid licking in rodents is an example of a promising, simple model of a CPG: It is a highly stereotyped behavior characterized by rhythmic tongue and jaw movements, and it is thought to be controlled by a neural substrate distributed in the medullary reticular formation in the brainstem. In preliminary observations, we have demonstrated that mice are a superb species choice for investigating the genetic basis of the licking CPG- the common inbred strains C57BL/6J (B6) and DBA/2J (D2) have a robust, non-overlapping phenotypic difference in lick rate. The identification of genes underlying differences in lick rate should have a huge payout for the study of CPGs. Mice can then created with gene-targeted deletions or insertions, allowing for specific physiological or anatomical investigation. We propose to take advantage of a newly augmented resource for our genetic dissection of licking: The BXD advanced recombinant inbred (Rl) strain set. These mice will allow for precision genetic mapping of quantitative trait loci (QTL) that underlie behavioral traits. We propose to use a novel high-throughput assay for lick rate to test a set of -80 BXD Rl strains, and map quantitative trait loci (QTLs) with high precision that underlie strain variation in lick rate. Relevance: Complex animals such as humans possess a number of motor responses that are stereotypic and/or repetitive in nature. Comparison of the genes and mechanisms underlying stereotyped repetitive movements vs. plastic behaviors will be a source of information relevant for a number of human CMS disorders involving abnormal repetitive movements.

中枢模式发生器（CPGs）是一种有节奏的活跃神经网络，是许多刻板印象的基础

项目成果

Orosensory responsiveness to and preference for hydroxide-containing salts in mice.

小鼠对含氢氧化物盐的口腔感觉反应和偏好。

• DOI: 10.1093/chemse/bjp023
• 发表时间: 2009
• 期刊: Chemical senses
• 影响因子: 3.5
• 作者: StJohn,StevenJ;BoughterJr,JohnD
• 通讯作者: BoughterJr,JohnD

Effects of sensory or motor nerve deafferentation on oromotor function in mice.

感觉或运动神经传入神经阻滞对小鼠口腔运动功能的影响。

• DOI: 10.1177/0194599811399722
• 发表时间: 2011
• 期刊: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
• 作者: Shires,CourtneyB;Saputra,JenniferM;Stocks,RoseMaryS;Sebelik,MerryE;BoughterJr,JohnD
• 通讯作者: BoughterJr,JohnD