Investigation of the relationship between vocal fold tension and electrical stimulation of the recurrent laryngeal nerve in a canine model

犬模型声带张力与喉返神经电刺激关系的研究

• 批准号: EP/E04087X/1
• 负责人: Eric Goodyer
• 金额: $ 2.01万
• 依托单位: De Montfort University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE04087X%2F1
• 关键词: Investigation; relationship; between; vocal; fold

UCLA are developing a new surgical technique for people who are suffering from the total loss of voice. The cause of this disease is often due to the total or partial paralysis of what is popularly called the 'vocal cord'. Our interest is in the nerve that stimulates the muscles that stretch the 'vocal cord', which then allows us to vibrate our 'voice box' and speak.Another surgical technique is currently in use to treat people suffering from spasmodic dysphonia. This is another little understood disease that cause the 'voice box' to vibrate when we do not want it to do so. Thus sufferers have a disturbed speech pattern. The team at UCLA has been successfully applying a surgical technique to cure this disease that relies on moving the nerve that stimulates the muscle, from one position to another. Known as 'Selective Laryngeal Adductor Denervation-Reinervation' this technique has been shown to be successful in about 70% of patients treated. The UCLA team now wish to apply their surgical skills to treating paralysis of the vocal fold by reinervation of the Recurrent Laryngeal Nerve (RLN); but before we attempt this treatment we need to understand more about how the RLN works.This is a small study, using dogs, which will measure the change in the stiffness (i.e. effectiveness) of the vocal fold when different levels of electrical stimulation are applied to the nerve. From this data we will be able to quantify the relationship, and thus develop the new surgical procedure.If successful then we will be able to make people suffering from paralysis of the 'voice box' to speak again.

加州大学洛杉矶分校正在开发一种新的手术技术，用于治疗完全失声的人。这种疾病的原因通常是由于人们通常所说的声带完全或部分瘫痪。我们感兴趣的是刺激伸展“声带”的肌肉的神经，然后让我们震动“声箱”说话。另一种外科技术目前正在用于治疗痉挛性发音困难的患者。这是另一种鲜为人知的疾病，当我们不想让它振动时，它会导致它振动。因此，患者的语言模式受到了干扰。加州大学洛杉矶分校的研究小组已经成功地应用了一种外科技术来治愈这种疾病，这种技术依赖于将刺激肌肉的神经从一个位置移动到另一个位置。这项技术被称为“选择性喉内收肌去神经-再支配”，已被证明在大约70%的接受治疗的患者中是成功的。加州大学洛杉矶分校的研究小组现在希望将他们的外科技能应用于通过重新支配喉返神经(RLN)来治疗声带瘫痪；但在尝试这种治疗之前，我们需要更多地了解RLN是如何工作的。这是一项使用狗的小型研究，将测量不同水平的电刺激对神经施加时声带僵硬(即有效性)的变化。根据这些数据，我们将能够量化这种关系，从而开发出新的外科手术程序。如果成功，那么我们将能够使患有‘喉咙’瘫痪的人再次说话。