The development of terahertz technology for physical, biological, and medical imaging and spectroscopy

物理、生物和医学成像和光谱学太赫兹技术的发展

• 批准号: EP/E048811/1
• 负责人: Edmund Harold Linfield
• 金额: $ 111.08万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE048811%2F1
• 关键词: development; terahertz; technology; physical; biological

The Basic Technology Research Programme provided us with a unique opportunity for the establishment of a technological platform in the UK for imaging and spectroscopy at terahertz (THz) frequencies. This region of the electromagnetic spectrum lies between the microwave and the mid-infrared (300GHz to 30THz), and had remained largely unexplored owing to the lack of suitable sources and detectors. Yet, there was an enormous potential for this spectral range with projected applications ranging from medical and dental imaging and spectroscopy, through to atmospheric sensing, wireless area communications, and astronomy.We have made many key developments on our Basic Technology Research Programme. These include:1) A very broad bandwidth THz spectroscopy system that has been used for studying drugs-of-abuse and explosives;2) A highly sensitive on-chip spectrometer, which can be used for genetic analysis;3) A new design of semiconductor laser operating at more than one frequency simultaneously with applications to gas sensing and pollution monitoring;4) An analysis of pharmaceutical compounds using THz and MRI, and the study of diffusion processes in polymers. This is likely to have impact on controlled-release pharmaceutical mechanisms;5) The construction of a high-pressure combustion chamber, which can be used for making THz measurements of high-pressure flames. This has applications to the optimisation and improvement of aircraft engines.Whilst excellent progress has been made, there is still plenty of research to be undertaken. We thus have applied for a 'Translation' grant to take these research topics further, and determine which of these (several of which we have patented) is likely to be taken up by industry, and find widescale applicability.

基础技术研究计划为我们提供了一个独特的机会，在英国建立太赫兹（THz）频率成像和光谱技术平台。这一电磁波谱区域位于微波和中红外（300 GHz至30 THz）之间，由于缺乏合适的光源和探测器，因此在很大程度上尚未被探索。然而，这个光谱范围的应用潜力巨大，从医学和牙科成像和光谱学，到大气传感，无线区域通信和天文学。我们在基础技术研究计划中取得了许多重要进展。其中包括：1）用于研究滥用药物和爆炸物的非常宽带宽的THz光谱系统;2）可用于遗传分析的高灵敏度片上光谱仪;3）同时在一个以上频率下工作的半导体激光器的新设计，用于气体传感和污染监测;4）使用THz和MRI分析药物化合物，以及研究聚合物中的扩散过程。这可能会对控释药物机制产生影响;5）高压燃烧室的构建，可用于对高压火焰进行太赫兹测量。这在飞机发动机的优化和改进方面有应用。虽然已经取得了很好的进展，但仍有大量的研究需要进行。因此，我们已经申请了“翻译”资助，以进一步开展这些研究课题，并确定其中哪些（其中几个我们已经申请了专利）可能被行业采用，并找到可扩展的适用性。

项目成果

Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis

• DOI: 10.1039/b817839a
• 发表时间: 2009-01-01
• 期刊: ANALYST
• 影响因子: 4.2
• 作者: Burnett, Andrew D.;Fan, Wenhui;Davies, A. Giles
• 通讯作者: Davies, A. Giles

Coherent sampling of active mode-locked terahertz quantum cascade lasers and frequency synthesis

• DOI: 10.1038/nphoton.2011.49
• 发表时间: 2011-05-01
• 期刊: NATURE PHOTONICS
• 影响因子: 35
• 作者: Barbieri, Stefano;Ravaro, Marco;Davies, A. Giles
• 通讯作者: Davies, A. Giles

High-Temperature Operation of Terahertz Quantum Cascade Laser Sources

• DOI: 10.1109/jstqe.2009.2013183
• 发表时间: 2009-05-01
• 期刊: IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
• 影响因子: 4.9
• 作者: Belkin, Mikhail A.;Wang, Qi Jie;Capasso, Federico
• 通讯作者: Capasso, Federico

Graded photonic crystal terahertz quantum cascade lasers

• DOI: 10.1063/1.3273056
• 发表时间: 2010-01-18
• 期刊: APPLIED PHYSICS LETTERS
• 影响因子: 4
• 作者: Chassagneux, Y.;Colombelli, R.;Davies, A. G.
• 通讯作者: Davies, A. G.

Simultaneous measurement of orthogonal components of polarization in a free-space propagating terahertz signal using electro-optic detection

使用电光检测同时测量自由空间传播太赫兹信号中偏振的正交分量

• DOI: 10.1063/1.3579258
• 发表时间: 2011
• 期刊: Applied Physics Letters
• 影响因子: 4
• 作者: Byrne M