A Program of Research and Mentorship on Alcoholism and Co-occuring Disorders

描述（由申请人提供）：我想通过这个K24奖在未来5年实现两个目标：深化我自己的研究计划，专注于双重诊断的人的治疗，并通过帮助开发我们设施的下一代临床研究人员，促进新墨西哥州大学成瘾临床研究更广泛计划的发展。迄今为止，我的研究主要集中在临床试验，双重诊断的互助方法，以及其他关于合并症和12步计划的研究。目前的赠款资金包括R 01赠款，用于研究改良的12步促进疗法的疗效， 严重精神病酗酒者（R 01 AA 015419），以及NIDA西南节点的U10补助金 临床试验网络（U10 DA 1533）。我有丰富的研究指导经验，与初级教师，研究员，精神病住院医生，博士。候选人和医学生。成瘾研究和指导的机构资源包括UNM酒精中毒，药物滥用和成瘾中心，医学院和MIND成像中心的教师，学员和基础设施，以及多样化和可访问的临床人群。提出了六个具体目标。 该研究的具体目的是：1）学习对发展共病临床研究至关重要的方法; 2）进行初步研究，支持发展一种新的药物治疗方法，用于酒精依赖和共病焦虑症患者，包括双硫仑和苯二氮卓类药物的联合给药，一种16周的治疗模型; 3）开发，提交，并获得研究这种药物治疗方法的R 01补助金的资金。指导具体目标是4）指导至少3名初级教师提交独立NIH资助的建议; 5）通过参与正在进行的研究项目，每年向至少3名成瘾精神病学研究员，研究生或精神病学居民提供研究培训;及6）透过各种低强度的导师及教育活动，为更广泛的团体提供持续培训及教育。 相关性：精神疾病和酗酒经常同时发生，造成不成比例的痛苦和代价。有必要更好地了解和更有效的治疗这些条件。该补助金支持在这一重要领域开发新的研究方法和新的研究人员。

DESCRIPTION (provided by applicant): I want to achieve two goals in the next 5 years through this K24 award: to deepen my own program of research, focusing on the treatment of dually diagnosed persons, and to facilitate the development of a more extensive program of clinical research in addictions at the University of New Mexico by helping to develop the next generation of clinical researchers at our facilities. My research to date has focused on clinical trials, mutual help approaches for the dually diagnosed, and other research on comorbidity and 12-step programs. Current grant funding includes an R01 grant to study the efficacy of a modified 12-step facilitation therapy for seriously mentally ill alcoholics (R01AA015419), and a U10 grant for the Southwest Node of the NIDA Clinical Trials Network (U10DA1533). I have extensive research mentoring experience with junior faculty, fellows, psychiatric residents, Ph.D. candidates, and medical students. Institutional resources for research and mentorship in addictions include faculty, trainees, and infrastructure at the UNM Center on Alcoholism, Substance Abuse, and Addiction, the School of Medicine, and the MIND Imaging Center, as well as diverse and accessible clinical populations. Six Specific Aims are proposed. The research Specific Aims are 1) To leam methodologies critical to the development of programmatic clinical research on comorbid conditions; 2) To conduct preliminary studies supporting the development of a novel pharrnacotherapeutic approach for individuals with alcohol dependence and co-occurring anxiety disorders, involving the co-administration of disulfiram and a benzodiazepine a 16-week model of treatment; 3) To develop, submit, and obtain funding for an R01 grant studying this pharrnacotherapeutic approach. The mentorship Specific Aims are 4) to mentor at least 3 junior faculty members to the point of submitting proposals for independent NIH funding; 5) to provide research training to at least three addiction psychiatry fellows, graduate students, or psychiatry residents per year through participation in ongoing research projects; and 6) To provide ongoing training and education to a broader group through a variety of lower-intensity mentorship and educational activities. Relevance: Mental illness and alcoholism frequently occur together, resulting in disproportionate suffering and cost. There is a need for better understanding and more effective treatments for these conditions. This grant supports the development of new research approaches and new researchers in this important field.