Clinical Trial Network: Southwest Node

描述(由申请人提供)：新墨西哥大学酒精中毒、药物滥用和成瘾中心(CASAA)提交了一份申请，要求续签NIDA临床试验网络(CTN)的西南节点。在最初的资助期，西南节点为CTN的研究活动作出了大量和具有成本效益的贡献。该节点已经成功地完成了五个方案，以及在印第安人治疗方案中对其中一个方案(求职者研讨会，方案0020)进行的单点改编。除了参与协议外，该节点还在协议开发、培训和委员会工作领域做出了重要贡献。在CCTN提供的最新节点绩效指标中(2005年8月至2006年7月)，西南节点在与试用性能有关的所有6项节点绩效指标中的得分都达到或高于全国平均水平。Node为促进少数族裔和其他服务不足人群成瘾治疗的临床科学做出了杰出贡献，贡献了CTN方案所有拉美裔参与者的17%，以及所有美洲原住民参与者的54%，包括登记参加0020方案改编的102名美洲原住民。西南节点也非常积极地将基于CTN的治疗方法推广到实践中，我们所有的CTP已经采用了一种或多种新的循证治疗方法。西南节点的特别优势包括：1)行为疗法和药物疗法的临床试验的良好记录；2)开发和评估成瘾创新疗法的长期经验；3)对具有挑战性的人群，包括共生障碍、无家可归者、离家出走的青少年和孕妇的丰富经验；4)传播和培训研究方面的专业知识；5)Node CTP中少数族裔患者高度集中(70%)；以及6)西南边境地区的地理代表性。为了说明可以从西南节点启动的CTN范围内的研究，描述了一个方案概念，提出了使用药物管理模式进行双硫仑治疗可卡因依赖的务实试验。相关性：这项工作支持CTN的使命，即利用科学方法改善美国的药物滥用治疗，在现实世界中对药物滥用治疗干预措施进行严格的多地点试验，并促进循证做法的传播。

DESCRIPTION (provided by applicant): The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits an application for renewal of the Southwest Node of the NIDA Clinical Trials Network (CTN). In its initial funding period, the Southwest Node has made a substantial and cost-effective contribution to the research activities of the CTN. The Node has successfully completed five protocols, as well as a single-site adaptation of one of these protocols (Job Seekers Workshop, protocol 0020) at a treatment program for Native Americans. Beyond participation in protocols, the Node has made important contributions in the areas of protocol development, training, and committee work. In the most recent Node performance measures available from the CCTN (August 2005-July 2006), the Southwest Node scored at or above national average on all 6 of the Node performance measures relating to trial performance. The Node has made an outstanding contribution to advancing the clinical science of addictions treatment in minority and other underserved populations, contributing 17% of all Hispanic participants in CTN protocols, and 54% of all Native American participants, including 102 Native Americans enrolled in the adaptation of protocol 0020. The Southwest Node has also been highly active in disseminating CTN-based treatments into practice, and all of our CTPs have already adopted one or more new evidence-based treatments. Particular strengths of the Southwest Node include: 1) a well-established track record of clinical trials for both behavioral treatments and pharmacotherapies; 2) longstanding experience in the development and evaluation of innovative treatments for addictions; 3) substantial experience with challenging populations including co-occurring disorders, the homeless, runaway adolescents, and pregnant women; 4) expertise in research on dissemination and training; 5) a high concentration (70%) of minority patients in the Node CTPs; and 6) geographic representation of the border Southwest. To illustrate CTN-wide research that could be initiated from the Southwest Node, a protocol concept is described proposing a pragmatic trial of disulfiram for cocaine dependence using a medication management model. Relevance: This work supports the CTN's mission to improve drug abuse treatment in the United States using the methods of science to conduct rigorous multi-site trials of substance abuse treatment interventions in real-world settings, and to facilitate the dissemination of evidence-based practices.