Clinical Trial Network: Southwest Node

临床试验网络：西南节点

• 批准号: 7924342
• 负责人: Michael Parks Bogenschutz
• 金额: $ 10万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924342
• 关键词: Adolescent; Adopted; Alcoholism; Area; Behavior Therapy; Characteristics; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials Network; Cocaine; Cocaine Dependence; Development; Disease; Disulfiram; Drug abuse; Educational workshop; Effectiveness; Enrollment; Evaluation; Evidence based practice; Evidence based treatment; Funding; Hispanics; Homelessness; Intervention; Knowledge; Manuals; Measures; Mediating; Medication Management; Methods; Minority; Mission; Modeling; National Institute of Drug Abuse; Native Americans; Network-based; New Mexico; Occupations; Outcome Measure; Participant; Patient Self-Report; Patients; Performance; Pharmaceutical Preparations; Pharmacotherapy; Placebo Effect; Population; Pregnant Women; Protocols documentation; Randomized; Research; Research Activity; Runaway; Safety; Science; Site; Specific qualifier value; Substance abuse problem; Testing; Therapeutic Effect; Training; Underserved Population; United States; Universities; Urine; Work; addiction; cocaine use; cost; double-blind placebo controlled trial; experience; improved; innovation; multi-site trial; pragmatic trial; primary outcome; protocol development; psychosocial; response; treatment as usual; treatment effect; treatment program

DESCRIPTION (provided by applicant): The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits an application for renewal of the Southwest Node of the NIDA Clinical Trials Network (CTN). In its initial funding period, the Southwest Node has made a substantial and cost-effective contribution to the research activities of the CTN. The Node has successfully completed five protocols, as well as a single-site adaptation of one of these protocols (Job Seekers Workshop, protocol 0020) at a treatment program for Native Americans. Beyond participation in protocols, the Node has made important contributions in the areas of protocol development, training, and committee work. In the most recent Node performance measures available from the CCTN (August 2005-July 2006), the Southwest Node scored at or above national average on all 6 of the Node performance measures relating to trial performance. The Node has made an outstanding contribution to advancing the clinical science of addictions treatment in minority and other underserved populations, contributing 17% of all Hispanic participants in CTN protocols, and 54% of all Native American participants, including 102 Native Americans enrolled in the adaptation of protocol 0020. The Southwest Node has also been highly active in disseminating CTN-based treatments into practice, and all of our CTPs have already adopted one or more new evidence-based treatments. Particular strengths of the Southwest Node include: 1) a well-established track record of clinical trials for both behavioral treatments and pharmacotherapies; 2) longstanding experience in the development and evaluation of innovative treatments for addictions; 3) substantial experience with challenging populations including co-occurring disorders, the homeless, runaway adolescents, and pregnant women; 4) expertise in research on dissemination and training; 5) a high concentration (70%) of minority patients in the Node CTPs; and 6) geographic representation of the border Southwest. To illustrate CTN-wide research that could be initiated from the Southwest Node, a protocol concept is described proposing a pragmatic trial of disulfiram for cocaine dependence using a medication management model. Relevance: This work supports the CTN's mission to improve drug abuse treatment in the United States using the methods of science to conduct rigorous multi-site trials of substance abuse treatment interventions in real-world settings, and to facilitate the dissemination of evidence-based practices.

描述（由申请人提供）：新墨西哥大学酒精中毒、药物滥用和成瘾中心（CASAA）提交了一份NIDA临床试验网络（CTN）西南节点的续期申请。在其最初供资期间，西南节点对CTN的研究活动作出了大量和具有成本效益的贡献。Node已经成功地完成了五个协议，以及其中一个协议（求职者研讨会，协议0020）的单站点改编，用于印第安人的治疗项目。除了参与协议之外，Node还在协议开发、培训和委员会工作方面做出了重要贡献。在CCTN提供的最新节点性能测量中（2005年8月至2006年7月），西南节点在与试验性能相关的所有6项节点性能测量中得分达到或高于全国平均水平。Node在促进少数族裔和其他服务不足人群成瘾治疗的临床科学方面做出了杰出贡献，贡献了17%的西班牙裔CTN协议参与者和54%的美洲原住民参与者，包括102名美洲原住民参与了协议0020的改编。西南节点也高度积极地将基于ctn的治疗方法推广到实践中，我们所有的ctp都已经采用了一种或多种新的循证治疗方法。西南节点的特殊优势包括：1)在行为治疗和药物治疗方面有着完善的临床试验记录；2)在开发和评估创新成瘾治疗方面的长期经验；3)与具有挑战性的人群打交道的丰富经验，包括共同发生的疾病、无家可归者、离家出走的青少年和孕妇；4)传播和培训研究方面的专门知识；5)淋巴结CTPs的少数患者浓度高（70%）；6)西南边境的地理分布。为了说明可以从西南节点发起的ctn范围的研究，描述了一个方案概念，提出了使用药物管理模型对可卡因依赖进行双硫仑的实用试验。相关性：这项工作支持CTN的使命，即利用科学方法在现实环境中对药物滥用治疗干预进行严格的多地点试验，改善美国的药物滥用治疗，并促进循证实践的传播。