Clinical Trial Network: Southwest Node

新墨西哥大学酒精中毒、药物滥用和成瘾中心(CASAA)提交了一份 申请更新NIDA临床试验网络(CTN)的西南节点。在其最初的资金中 在此期间，西南节点为研究活动作出了大量和具有成本效益的贡献 CTN的。该节点已成功完成五个协议以及一个协议的单站点改编 这些协议(求职者研讨会，协议0020)在土著美国人的治疗计划中。 除了参与协议之外，节点还在协议领域做出了重要贡献 发展、培训和委员会工作。在以下网站提供的最新节点性能指标中 CCTN(2005年8月至2006年7月)，西南节点在所有6项指标中的得分均达到或高于全国平均水平 与试用性能相关的节点性能衡量标准。Node做出了杰出的贡献 为促进少数民族和其他服务不足人群的成瘾治疗的临床科学， 在CTN协议中贡献了17%的西班牙裔参与者和54%的印第安人参与者， 其中包括102名登记参加0020议定书改编的美洲原住民。西南节点也有 非常积极地将以CTN为基础的治疗方法推广到实践中，我们所有的CTP已经 采用了一种或多种新的循证治疗方法。西南节点的特殊优势包括： 1)良好的行为治疗和药物治疗临床试验记录； 2)在开发和评估成瘾创新疗法方面的长期经验； 3)在具有挑战性的人群中拥有丰富的经验，包括共生疾病、无家可归者、 离家出走的青少年和孕妇；4)传播和培训研究方面的专门知识；5)高 少数民族患者集中(70%)在Node CTP；以及6)边界的地理分布 西南。为了说明可以从西南节点发起的CTN范围内的研究，该协议 概念描述提出了一种使用药物治疗可卡因依赖的双硫仑的实用试验 管理模式。相关性：这项工作支持CTN改善#年药物滥用治疗的使命 美国使用科学方法对药物滥用进行严格的多地点试验 在现实世界环境中采取治疗干预措施，并促进循证做法的传播。

The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits an application for renewal of the Southwest Node of the NIDA Clinical Trials Network (CTN). In its initial funding period, the Southwest Node has made a substantial and cost-effective contribution to the research activities of the CTN. The Node has successfully completed five protocols, as well as a single-site adaptation of one of these protocols (Job Seekers Workshop, protocol 0020) at a treatment program for Native Americans. Beyond participation in protocols, the Node has made important contributions in the areas of protocol development, training, and committee work. In the most recent Node performance measures available from the CCTN (August 2005-July 2006), the Southwest Node scored at or above national average on all 6 of the Node performance measures relating to trial performance. The Node has made an outstanding contribution to advancing the clinical science of addictions treatment in minority and other underserved populations, contributing 17% of all Hispanic participants in CTN protocols, and 54% of all Native American participants, including 102 Native Americans enrolled in the adaptation of protocol 0020. The Southwest Node has also been highly active in disseminating CTN-based treatments into practice, and all of our CTPs have already adopted one or more new evidence-based treatments. Particular strengths of the Southwest Node include: 1) a well-established track record of clinical trials for both behavioral treatments and pharmacotherapies; 2) longstanding experience in the development and evaluation of innovative treatments for addictions; 3) substantial experience with challenging populations including co-occurring disorders, the homeless, runaway adolescents, and pregnant women; 4) expertise in research on dissemination and training; 5) a high concentration (70%) of minority patients in the Node CTPs; and 6) geographic representation of the border Southwest. To illustrate CTN-wide research that could be initiated from the Southwest Node, a protocol concept is described proposing a pragmatic trial of disulfiram for cocaine dependence using a medication management model. Relevance: This work supports the CTN's mission to improve drug abuse treatment in the United States using the methods of science to conduct rigorous multi-site trials of substance abuse treatment interventions in real-world settings, and to facilitate the dissemination of evidence-based practices.